The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 54
Опубликована: Апрель 5, 2025
Cancer
is
a
leading
cause
of
mortality
and
morbidity
worldwide.
Nanomaterials,
unique
optical,
magnetic,
electrical
properties
at
the
nanoscale
(1-100
nm),
have
been
engineered
to
improve
drug
capacity,
bioavailability,
specificity
in
cancer
treatment.
These
advancements
address
toxicity
lack
selectivity
conventional
therapies,
enabling
precise
targeting
cells,
tumor
microenvironment,
immune
system.
Among
emerging
approaches,
bacterial
treatment
shows
promise
due
its
natural
ability
target
diverse
therapeutic
mechanisms,
which
nanotechnology
can
further
enhance.
Bacteria-based
delivery
systems
leverage
bacteria's
adaptability
survival
strategies
within
human
body.
Bacterial
derivatives,
such
as
ghosts
(BGs),
extracellular
vesicles
(BEVs),
dietary
toxins,
are
recognized
effective
biological
nanomaterials
capable
carrying
nanoparticles
(NPs).
attracted
increasing
attention
for
their
potential
targeted
NP
This
study
explores
use
various
bacteria
byproducts
vehicles,
highlighting
treating
different
types
cancer.
By
combining
strengths
therapy,
these
innovative
approaches
aim
revolutionize
with
improved
precision
efficacy.
Язык: Английский
Phototheranostic Zinc Porphyrin Nanoparticles Triggered by an 808 nm Laser: NIR-II Fluorescence/Photoacoustic Imaging-Guided Combined Photothermal/Photodynamic/NO Therapy
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Single-wavelength
lasers
that
trigger
intelligently
designed
multifunctional
theranostic
nanoplatforms
are
urgently
needed
for
early
cancer
diagnosis
and
imaging-guided
therapy.
In
this
study,
a
novel
zinc
porphyrin,
Por-TR,
was
fabricated
by
incorporating
thiophene
as
donor
introducing
electron
acceptors
on
both
sides
to
expand
the
conjugation.
The
presence
of
multiple
flexible
chains
in
molecular
structure
Por-TR
inhibits
π-π
stacking,
which
allows
it
form
J
nanoaggregates
when
coassembled
with
DSPE-PEG2000,
demonstrating
maximum
absorption
at
approximately
808
nm.
These
NPs
provide
NIR-II
fluorescence/PA
dual-modal
signals
imaging
serve
combined
PTT/PDT
therapeutic
agent,
making
them
suitable
nanoplatform.
To
further
improve
their
effects,
we
embedded
thermosensitive
NO
donor,
BNN6,
nanosystem
achieve
PDT/PTT/NO
Intravenous
injection
Por-TR-NO
into
4T1
tumor-bearing
mice
enabled
accurate
observation
tumor
location
via
imaging.
vivo
therapy
results
show
exhibited
remarkable
antitumor
efficacy
PTT/PDT/NO
therapy,
triggered
an
nm
laser.
Overall,
nanoplatform
offers
versatile
approach
treatment.
Язык: Английский