Development and Evaluation of Hydrogel-Based Sulfasalazine-Loaded Nanosponges for Enhanced Topical Psoriasis Therapy DOI Creative Commons
Sunil Kumar, Anroop B. Nair, Varsha Kadian

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 391 - 391

Опубликована: Март 10, 2025

Background: The low solubility and poor skin permeability of sulfasalazine (SLZ) present significant challenges for its effective topical delivery. objective the current investigation is to formulate a hydrogel-based SLZ-loaded cyclodextrin nanosponge therapy in psoriasis. Methods: nanosponges were prepared by melt polymerization method evaluated physiochemical characteristics, drug release, cytocompatibility. selected (SLZ-NS4) transformed hydrogel further rheology, texture, safety, permeability, vivo anti-psoriatic effect mouse tail imiquimod-induced psoriasis-like inflammation models mice. Results: Physiochemical data confirms nanoscale architecture, inclusion nanosponges, crystalline structure, formulation stability. release profile SLZ-NS4 revealed sustained behavior (22.98 ± 2.24% 3 h). Cytotoxicity assays indicated negligible toxicity against THP1 cells, resulting higher viability cells than pure SLZ (p < 0.05). HET-CAM assay confirmed while confocal laser scanning microscopy demonstrated deeper permeation SLZ. In model, remarkable decline relative epidermal thickness, potential improvement percent orthokeratosis, activity with respect control was observed animals treated hydrogel. efficiency developed SLZ-NS4-loaded treating psoriasis PASI score (81.68 3.61 84.86 5.74 1 2% w/v SLZ-NS-HG). Histopathological analysis assessment oxidative stress markers profound fabricated Conclusions: These findings highlight delivery system as an

Язык: Английский

Cyclodextrin–Hydrogel Hybrids in Advanced Drug Delivery DOI Creative Commons
Hossein Omidian,

Arnavaz Akhzarmehr,

Erma J. Gill

и другие.

Gels, Год журнала: 2025, Номер 11(3), С. 177 - 177

Опубликована: Фев. 28, 2025

Cyclodextrin (CD)–hydrogel hybrids have emerged as versatile and multifunctional drug delivery systems, offering enhanced solubility, controlled release, improved bioavailability. By combining the inclusion complexation properties of CDs with swelling retention capabilities hydrogels, these hybrid systems overcome key challenges in conventional formulations. This review explores CD composition, hydrogel polymer selection, fabrication techniques, release factors, real-world therapeutic applications. Additionally, latest advancements stimuli-responsive nanogels, microneedle-based are discussed. While CD–hydrogel demonstrate significant potential, scalability, regulatory hurdles, clinical translation remain challenges. Future research should focus on smart loading strategies, validation to bridge gap between laboratory innovations commercial

Язык: Английский

Процитировано

0
Development and Evaluation of Hydrogel-Based Sulfasalazine-Loaded Nanosponges for Enhanced Topical Psoriasis Therapy DOI Creative Commons
Sunil Kumar, Anroop B. Nair, Varsha Kadian

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 391 - 391

Опубликована: Март 10, 2025

Background: The low solubility and poor skin permeability of sulfasalazine (SLZ) present significant challenges for its effective topical delivery. objective the current investigation is to formulate a hydrogel-based SLZ-loaded cyclodextrin nanosponge therapy in psoriasis. Methods: nanosponges were prepared by melt polymerization method evaluated physiochemical characteristics, drug release, cytocompatibility. selected (SLZ-NS4) transformed hydrogel further rheology, texture, safety, permeability, vivo anti-psoriatic effect mouse tail imiquimod-induced psoriasis-like inflammation models mice. Results: Physiochemical data confirms nanoscale architecture, inclusion nanosponges, crystalline structure, formulation stability. release profile SLZ-NS4 revealed sustained behavior (22.98 ± 2.24% 3 h). Cytotoxicity assays indicated negligible toxicity against THP1 cells, resulting higher viability cells than pure SLZ (p < 0.05). HET-CAM assay confirmed while confocal laser scanning microscopy demonstrated deeper permeation SLZ. In model, remarkable decline relative epidermal thickness, potential improvement percent orthokeratosis, activity with respect control was observed animals treated hydrogel. efficiency developed SLZ-NS4-loaded treating psoriasis PASI score (81.68 3.61 84.86 5.74 1 2% w/v SLZ-NS-HG). Histopathological analysis assessment oxidative stress markers profound fabricated Conclusions: These findings highlight delivery system as an

Язык: Английский

Процитировано

0