InFo Hämatologie + Onkologie, Год журнала: 2024, Номер 27(7-8), С. 46 - 57
Опубликована: Июль 1, 2024
World Journal of Gastrointestinal Surgery, Год журнала: 2025, Номер 17(3)
Опубликована: Фев. 24, 2025
In this article, we evaluate the findings of study by Qian et al , which explores efficacy combining hyperthermia with opioid therapy for enhanced cancer pain management in patients middle and late-stage gastrointestinal tumors. The undertakes a retrospective analysis comparing traditional to an integrated approach opioids across 70 patients, highlighting significant benefits control, reduction dosage, minimization adverse reactions. our not only discuss these but also emphasize broader implications clinical practice, particularly enhancing patient outcomes through innovative strategies. We advocate further research establish more robust data supporting explore mechanistic insights that enable benefits. This discussion reflects on potential paradigm shift managing debilitating cancer-related pain, urging reevaluation current practices incorporate effectively.
Язык: Английский
Процитировано
0
Strahlentherapie und Onkologie, Год журнала: 2024, Номер 200(6), С. 512 - 522
Опубликована: Янв. 4, 2024
Abstract Background Hyperthermia treatment quality is usually evaluated by thermal (dose) parameters, though hyperthermic radiosensitization effects are also influenced the time interval between two modalities. This work applies biological modelling for clinical evaluation of cervical cancer patients treated with radiotherapy plus hyperthermia calculating equivalent radiation dose (EQD RT , i.e., needed same effect alone). Subsequent analyses evaluate impact logistics. Methods Biological was performed 58 23–28 fractions 1.8–2 Gy 4–5 weekly sessions. Measured temperatures (T50) and recorded intervals sessions were used to calculate EQD using an extended linear quadratic (LQ) model LQ parameters based on extensive experimental data. Next, a 30-min (optimized logistics) as well 4‑h (suboptimal evaluated. Results Median average measured T50 41.2 °C (range 39.7–42.5 °C) 79 min 34–125 min), respectively, resulting in median total enhancement (D50) 5.5 (interquartile range [IQR] 4.0–6.6 Gy). For intervals, would increase ~30% 7.1 (IQR 5.5–8.1 Gy; p < 0.001). In case ~ 40% decrease could be expected: 3.2 2.3–3.8 Normal tissue negligible (< 0.3 Gy), even short intervals. Conclusion useful addition standard treatments. Optimizing logistics shorten seems worthwhile improve efficacy.
Язык: Английский
Процитировано
1
International Journal of Radiation Oncology*Biology*Physics, Год журнала: 2024, Номер 119(5), С. 1530 - 1544
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
1
Frontiers in Oncology, Год журнала: 2023, Номер 13
Опубликована: Дек. 19, 2023
Introduction Breast cancer is globally the leading in women, and despite high 5-year survival rate most frequent cause of related deaths. Surgery, systemic therapy radiotherapy are three pillars curative breast treatment. However, locoregional recurrences frequently occur after initial treatment often challenging to treat, amongst others due doses previous treatments. Radiotherapy can be combined with local hyperthermia sensitize tumor cells radiation thereby significantly reduce required dose. Therefore, combination mild hyperthermia, i.e. locally heating tissue 39-43°C, re-irradiation a reduced total dose relevant option for previously irradiated patients. The mechanisms this effect course date not well understood will investigated HISTOTHERM study. Methods analyses Patients or (loco)regional recurrent macroscopic tumors included Local control evaluated clinically histologically during 60 minutes superficial (39 - 43°C) using water-filtered infrared A (wIRA) irradiation, immediately followed by hypofractionated 20-24 Gy, administered weekly 4 Gy. Tumor stroma biopsies as blood samples collected prior treatment, (at 12 Gy) follow-up monitor response. represents standard operating procedure plus re-irradiation. Various blood-based markers analyzed. We aim at pinpointing key response which may help guiding decisions future. In addition, quality life assessed data evaluated. Registration study registered German Clinical Trials Register, Deutsches Register Klinischer Studien (DRKS00029221).
Язык: Английский
Процитировано
2
International Journal of Hyperthermia, Год журнала: 2024, Номер 41(1)
Опубликована: Март 11, 2024
Introduction Hyperthermia (HT) induces various cellular biological processes, such as repair impairment and direct HT cell killing. In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study extent of processes their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions.
Язык: Английский
Процитировано
0
International Journal of Radiation Oncology*Biology*Physics, Год журнала: 2024, Номер 120(5), С. 1435 - 1447
Опубликована: Июль 15, 2024
IntroductionThe combined effect of hyperthermia and radiotherapy can be quantified by an enhanced equivalent radiation dose (EQDRT). Uncertainties in treatment planning adjustments during impact achieved EQDRT. We developed compared strategies for EQDRT optimization plans, focusing on robustness against common adjustments.MethodsUsing Plan2Heat, we computed pre-planning plans adjustment scenarios three cervical cancer patients. imported these into RayStation 12A with four different strategies: (1) Conventional prescribing 46 Gy to the target volume (PTV), (2) Nominal using scenario, targeting uniform 58 gross tumor (GTV), keeping organs at risk (OAR) doses as plan (1), (3) Robust optimization, but adding adjusted (4) Library Plans (four plans), strategy criteria optimizing one scenario per plan. calculated each distributions scenarios, evaluating combination GTV coverage homogeneity objectives.ResultsEQDRT95% increased from 49.9-50.9 56.1-57.4 improving ∼10%. Strategy demonstrated best overall robustness, 62% all objectives within tolerance. had higher percentage tolerance than (68% vs 54%), lower uniformity (44% 71%). showed similar EQDRT95% scenario. D0.1% OARs was (2-4) up ∼6 Gy.ConclusionsEQDRT enhances levels conventional optimization. Better is improves reduces homogeneity. A library ensures when dealing scenarios.
Язык: Английский
Процитировано
0
InFo Hämatologie + Onkologie, Год журнала: 2024, Номер 27(7-8), С. 46 - 57
Опубликована: Июль 1, 2024
Процитировано
0