Correlation between rCBV Delineation Similarity and Overall Survival in a Prospective Cohort of High-Grade Gliomas Patients: The Hidden Value of Multimodal MRI?

Biomedicines, Год журнала: 2024, Номер 12(4), С. 789 - 789

Опубликована: Апрель 3, 2024

Purpose: The accuracy of target delineation in radiation treatment planning high-grade gliomas (HGGs) is crucial to achieve high tumor control, while minimizing treatment-related toxicity. Magnetic resonance imaging (MRI) represents the standard modality for with inherent limitations accurately determining microscopic extent tumors. purpose this study was assess survival impact multi-observer variability multiparametric MRI (mpMRI) and [18F]-FET PET/CT. Materials Methods: Thirty prospectively included patients histologically confirmed HGGs underwent a PET/CT mpMRI including diffusion-weighted (DWI: b0, b1000, ADC), contrast-enhanced T1-weighted (T1-Gado), T2-weighted fluid-attenuated inversion recovery (T2Flair), perfusion-weighted computation relative cerebral blood volume (rCBV) K2 maps. Nine oncologists delineated sequences. Spatial similarity (Dice coefficient: DSC) calculated between readers each sequence. Impact DSC on progression-free (PFS) overall (OS) assessed using Kaplan–Meier curves log-rank test. Results: highest mean values were reached morphological sequences, ranging from 0.71 +/− 0.18 0.84 0.09 T2Flair T1Gado, respectively, metabolic volumes defined by achieved 0.75 0.11. rCBV (mean DSC0.32 0.20) significantly impacted PFS (p = 0.02) OS 0.002). Conclusions: Our data suggest that T1-Gado sequences most reproducible followed Reproducibility functional low, but inter-reader OS.

Язык: Английский

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Factors of interobserver variability in prostate tumor MRI delineation: impact of PI-QUAL score

La radiologia medica, Год журнала: 2024, Номер 129(12), С. 1890 - 1897

Опубликована: Ноя. 8, 2024

Язык: Английский

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Inter-Rater Variability of Prostate Lesion Segmentation on Multiparametric Prostate MRI

Biomedicines, Год журнала: 2023, Номер 11(12), С. 3309 - 3309

Опубликована: Дек. 14, 2023

External radiotherapy is a major treatment for localized prostate cancer (PCa). Dose escalation to the whole gland increases biochemical relapse-free survival but also acute and late toxicities. dominant index lesion (DIL) only of growing interest. It requires robust delineation DIL. In this context, we aimed evaluate inter-observer variability DIL delineation.Two junior radiologists senior radiation oncologist delineated DILs on 64 mpMRIs patients with histologically confirmed PCa. For each mpMRI reader, eight individual segmentations were delineated. These delineations blindly performed from one another resulted analysis T2, apparent diffusion coefficient (ADC), b2000, dynamic contrast enhanced (DCE) sequences, as well combined sequences (T2ADC, T2ADCb2000, T2ADCDCE, T2ADCb2000DCE). Delineation was assessed using DICE coefficient, Jaccard index, Hausdorff distance measure, mean agreement.T2, ADC, T2ADC, T2 + ADC DCE, b2000 DCE obtained coefficients 0.51, 0.50, 0.54, 0.52, 0.55, 0.53, respectively, which are significantly higher than perfusion sequence alone (0.35, p < 0.001). The other similarity metrics lead similar results. tumor volume PI-RADS classification positively correlated scores.Our study showed that contours prostatic lesions more reproducible certain great maximum calculated at 0.55 (joint sequences).

Язык: Английский

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A Comprehensive Primer on Radiation Oncology for Non-Radiation Oncologists

Cancers, Год журнала: 2023, Номер 15(20), С. 4906 - 4906

Опубликована: Окт. 10, 2023

Multidisciplinary management is crucial in cancer diagnosis and treatment. teams include specialists surgery, medical therapies, radiation therapy (RT), each playing unique roles oncology care. One significant aspect RT, guided by oncologists (ROs). This paper serves as a detailed primer for non-oncologists, students, or non-clinical investigators, educating them on contemporary RT practices.

Язык: Английский

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Interobserver variability of clinical target volume delineation in patients undergoing breast-conserving surgery without surgical clips: a pilot study on preoperative magnetic resonance simulation

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 26, 2024

In patients undergoing breast-conserving therapy without surgical clip implantation, the accuracy of tumor bed identification and consistency clinical target volume (CTV) delineation under computed tomography (CT) simulation remain suboptimal. This study aimed to investigate feasibility implementing preoperative magnetic resonance (MR) on delineations by assessing interobserver variability (IOV). Preoperative MR postoperative CT simulations were performed in who underwent surgery with no clips implanted. Custom immobilization pads used ensure same supine position. Three radiation oncologists independently delineated CTV images acquired from registration alone. Cavity visualization score (CVS) was assigned each patient based clarity images. IOV indicated generalized conformity index (CIgen), denoted as CIgen−CT CIgen−MR/CT, distance between centroid mass (dCOM), dCOMCT dCOMMR/CT. The variation different CVS subgroups analyzed. A total 10 enrolled this study. median interquartile range (IQR) maximum pathological diameter tumors all 1.55 (0.80–1.92) cm. No statistical significance found volumes CTVs MR/CT (p = 0.387). CIgen−MR/CT significantly larger than 0.005). dCOMMR/CT smaller 0.037). IQR 2.34 (2.00–3.08). difference CIgen low group 0.016). dCOM showed a decreasing trend when lower, although it did not reach 0.095). For use delineating decreased among observers. improved especially cases where margins challenging visualize findings offer potential benefits reducing local recurrence minimizing tissue irritation surrounding areas. Future investigation cohort validate our results is warranted.

Язык: Английский

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