Understanding the tumor immune microenvironment (TIME) for effective therapy

Nature Medicine, Год журнала: 2018, Номер 24(5), С. 541 - 550

Опубликована: Апрель 20, 2018

Язык: Английский

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Macrophage plasticity, polarization, and function in health and disease

Journal of Cellular Physiology, Год журнала: 2018, Номер 233(9), С. 6425 - 6440

Опубликована: Янв. 10, 2018

Macrophages are heterogeneous and their phenotype functions regulated by the surrounding micro-environment. commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which pro-inflammatory polarized lipopolysaccharide (LPS) either alone association with Th1 cytokines such as IFN-γ, GM-CSF, produce interleukin-1β (IL-1β), IL-6, IL-12, IL-23, TNF-α; 2) Alternatively M2 anti-inflammatory immunoregulatory Th2 IL-4 IL-13 IL-10 TGF-β. macrophages have different transcriptional profiles. They unique abilities destroying pathogens repair inflammation-associated injury. It is known that M1/M2 macrophage balance polarization governs fate of an organ inflammation When infection severe enough to affect organ, first exhibit release TNF-α, IL-1β, IL-23 against stimulus. But, if phase continues, it can cause tissue damage. Therefore, secrete high amounts TGF-β suppress inflammation, contribute repair, remodeling, vasculogenesis, retain homeostasis. In this review, we discuss basic biology including origin, differentiation activation, distribution, plasticity polarization, migration, antigen presentation capacity, cytokine chemokine production, metabolism, involvement microRNAs function. Secondly, protective pathogenic role subsets normal pathological pregnancy, anti-microbial defense, anti-tumor immunity, metabolic disease obesity, asthma allergy, atherosclerosis, fibrosis, wound healing, autoimmunity.

Язык: Английский

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Macrophages in Tissue Repair, Regeneration, and Fibrosis

Immunity, Год журнала: 2016, Номер 44(3), С. 450 - 462

Опубликована: Март 1, 2016

Язык: Английский

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Tumour-associated macrophages as treatment targets in oncology

Nature Reviews Clinical Oncology, Год журнала: 2017, Номер 14(7), С. 399 - 416

Опубликована: Янв. 24, 2017

Язык: Английский

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Macrophage Polarization

Annual Review of Physiology, Год журнала: 2016, Номер 79(1), С. 541 - 566

Опубликована: Ноя. 4, 2016

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as are sufficiently plastic integrate multiple signals, such those from microbes, damaged tissues, the normal tissue environment. Three broad pathways control polarization: epigenetic cell survival that prolong or shorten macrophage development viability, microenvironment, extrinsic factors, microbial products cytokines released inflammation. A plethora of advances provided framework for rationally purifying, describing, manipulating polarization. Here, I assess current state knowledge about enumerate major questions regulate physiology tissues.

Язык: Английский

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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Nature Communications, Год журнала: 2016, Номер 7(1)

Опубликована: Июль 6, 2016

Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions MDSC to tumour progression through both immune-mediated mechanisms those not directly associated with suppression. are the subject intensive research >500 papers published 2015 alone. However, phenotypic, morphological functional heterogeneity these generates confusion investigation analysis their roles inflammatory responses. The purpose this communication is suggest characterization standards burgeoning field research.

Язык: Английский

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T cell exclusion, immune privilege, and the tumor microenvironment

Science, Год журнала: 2015, Номер 348(6230), С. 74 - 80

Опубликована: Апрель 2, 2015

Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific be generated, but also these physically contact The coexistence in some patients and recognize them indicates tumors may exhibit phenomenon immune privilege, which immunogenic tissue is protected from attack. Here, we review evidence stromal tumor microenvironment mediate this restriction excluding vicinity Overcoming cell checkpoint thus enable optimal immunotherapy.

Язык: Английский

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Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Cell, Год журнала: 2014, Номер 159(6), С. 1312 - 1326

Опубликована: Дек. 1, 2014

Язык: Английский

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Immune attack: the role of inflammation in Alzheimer disease

Nature reviews. Neuroscience, Год журнала: 2015, Номер 16(6), С. 358 - 372

Опубликована: Май 20, 2015

Язык: Английский

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Macrophages as regulators of tumour immunity and immunotherapy

Nature reviews. Immunology, Год журнала: 2019, Номер 19(6), С. 369 - 382

Опубликована: Фев. 4, 2019

Язык: Английский

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