Tertiary lymphoid structures and B cells: An intratumoral immunity cycle

Immunity, Год журнала: 2023, Номер 56(10), С. 2254 - 2269

Опубликована: Сен. 11, 2023

Язык: Английский

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T follicular helper cells in cancer

Trends in cancer, Год журнала: 2023, Номер 9(4), С. 309 - 325

Опубликована: Янв. 14, 2023

T follicular helper (Tfh) cells provide essential help to B for effective antibody-mediated immune responses. Although the crucial function of these CD4+ in infection and vaccination is well established, their involvement cancer only beginning emerge. Increased numbers Tfh cell-derived or cell-associated malignancies are often associated with an unfavorable outcome, whereas various solid organ tumor types non-lymphocytic origin, presence frequently coincides a better prognosis. We discuss recent advances understanding how cell crosstalk CD8+ secondary tertiary lymphoid structures (TLS) enhances antitumor immunity, but may also exacerbate immune-related adverse events (irAEs) such as autoimmunity during checkpoint blockade (ICB) immunotherapy.

Язык: Английский

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C1q+ macrophages: passengers or drivers of cancer progression

Trends in cancer, Год журнала: 2022, Номер 8(7), С. 517 - 526

Опубликована: Март 12, 2022

Язык: Английский

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B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 466 - 489

Опубликована: Март 1, 2023

Язык: Английский

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The advent of immune stimulating CAFs in cancer

Nature reviews. Cancer, Год журнала: 2023, Номер 23(4), С. 258 - 269

Опубликована: Фев. 17, 2023

Язык: Английский

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Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response

Immunity, Год журнала: 2022, Номер 55(10), С. 1940 - 1952.e5

Опубликована: Окт. 1, 2022

Язык: Английский

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Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(9), С. 583 - 603

Опубликована: Июнь 26, 2023

Язык: Английский

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Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Фев. 20, 2023

Abstract Although advances in spatial transcriptomics (ST) enlarge to unveil landscape of tissues, it remains challenging delineate pathology-relevant and cellular localizations, interactions exclusive a niche (e.g., tumor boundary). Here, we develop Cottrazm, integrating ST with hematoxylin eosin histological image, single-cell the boundary connecting malignant non-malignant cell spots deconvolute cell-type composition at location, reconstruct type-specific gene expression profiles sub-spot level. We validate performance Cottrazm along malignant-boundary-nonmalignant axis. identify specific macrophage fibroblast subtypes localized around that interacted cells generate structural boundary, which limits T infiltration promotes immune exclusion microenvironment. In this work, provides an integrated tool framework dissect microenvironment facilitates discovery functional biological insights, thereby identifying therapeutic targets oncologic datasets.

Язык: Английский

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A blueprint for tumor-infiltrating B cells across human cancers

Science, Год журнала: 2024, Номер 384(6695)

Опубликована: Май 2, 2024

B lymphocytes are essential mediators of humoral immunity and play multiple roles in human cancer. To decode the functions tumor-infiltrating cells, we generated a cell blueprint encompassing single-cell transcriptome, cell-receptor repertoire, chromatin accessibility data across 20 different cancer types (477 samples, 269 patients). cells harbored extraordinary heterogeneity comprised 15 subsets, which could be grouped into two independent developmental paths (extrafollicular versus germinal center). Tumor extrafollicular pathway were linked with worse clinical outcomes resistance to immunotherapy. The dysfunctional program was associated glutamine-derived metabolites through epigenetic-metabolic cross-talk, promoted T cell-driven immunosuppressive program. These suggest an intratumor balance between germinal-center responses that possibly harnessed for cell-targeting

Язык: Английский

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Immunosurveillance in clinical cancer management

CA A Cancer Journal for Clinicians, Год журнала: 2023, Номер 74(2), С. 187 - 202

Опубликована: Окт. 25, 2023

The progression of cancer involves a critical step in which malignant cells escape from control by the immune system. Antineoplastic agents are particularly efficient when they succeed restoring such (immunosurveillance) or at least establish an equilibrium state that slows down disease progression. This is true not only for immunotherapies, as checkpoint inhibitors (ICIs), but also conventional chemotherapy, targeted anticancer agents, and radiation therapy. Thus, therapeutics stress kill while provoking tumor-targeting response, referred to immunogenic cell death, useful combination with ICIs. Modern oncology regimens increasingly using combinations, chemoimmunotherapy, well combinations multiple However, latter generally associated severe side effects compared single-agent Of note, success these combinatorial strategies against locally advanced metastatic cancers now spurring successful attempts move them past postoperative (adjuvant) setting preoperative (neoadjuvant) setting, even patients operable cancers. Here, authors critically discuss importance immunosurveillance modern clinical management.

Язык: Английский

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