Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 22, 2025
The
favorable
prognosis
of
"hot"
tumors
is
widely
acknowledged
in
oncology.
Recently,
the
concept
tertiary
lymphoid
structures
(TLS)
has
renewed
appreciation
for
local
immune
cells
within
tumor
tissues.
Tissue-resident
cells,
a
newly
identified
subset
tumor-infiltrating
lymphocytes,
are
emerging
as
potential
key
players
infiltration
and
TLS
formation,
due
to
their
ability
reside
indefinitely
tissues
mount
effective
responses
antigens.
Cervical
cancer
(CC),
fourth
most
common
cause
cancer-related
mortality
among
women
globally,
experienced
comparatively
limited
progress
delineating
its
microenvironment
compared
other
malignancies.
Notably,
role
tissue-resident
CC
milieu
remains
inadequately
characterized.
This
comprehensive
review
aims
synthesize
current
knowledge
critically
evaluate
putative
roles
these
pathogenesis,
providing
new
insights
on
intricate
dynamics
microenvironment.
Autoimmunity Reviews,
Год журнала:
2025,
Номер
24(5), С. 103782 - 103782
Опубликована: Фев. 24, 2025
B
cells
play
a
key
role
in
the
pathophysiology
of
systemic
sclerosis
(SSc).
While
they
are
less
characterized
than
their
circulating
counterparts,
tissue-infiltrating
may
have
more
direct
pathological
tissues.
In
this
review,
we
decipher
multiple
evidence
infiltration
skin
and
lungs
SSc
patients
animal
models
but
also
other
chronic
fibrotic
diseases
with
similar
mechanisms
such
as
graft
versus
host
disease,
idiopathic
pulmonary
fibrosis
or
morphea.
We
recapitulate
current
knowledge
about
functions
Finally,
discuss
cell
targeted
therapies,
specific
impact
on
infiltrated
cells.
Understanding
local
consequences
infiltrating
is
an
important
step
for
better
management
improvement
therapies
SSc.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(14)
Опубликована: Апрель 1, 2025
The
lungs
are
constantly
exposed
to
the
external
environment
and
a
myriad
of
antigenic
challenges
within
air.
Chronic
exposure
allergens
other
airborne
antigens
can
result
in
formation
lymphocyte
aggregates
lung,
which
harbor
ectopic
germinal
centers
(GCs).
After
allergen
exposure,
GCs
that
form
lung
much
smaller
less
densely
packed
with
B
cells
than
lymph
node
GCs.
Despite
this,
support
somatic
hypermutation
affinity-based
maturation
as
GCs,
export
memory
(MBCs)
directly
into
tissue.
This
demonstrates
locally
diversify
cell
responses
supports
generation
tissue
MBC
populations
situ.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 22, 2025
The
favorable
prognosis
of
"hot"
tumors
is
widely
acknowledged
in
oncology.
Recently,
the
concept
tertiary
lymphoid
structures
(TLS)
has
renewed
appreciation
for
local
immune
cells
within
tumor
tissues.
Tissue-resident
cells,
a
newly
identified
subset
tumor-infiltrating
lymphocytes,
are
emerging
as
potential
key
players
infiltration
and
TLS
formation,
due
to
their
ability
reside
indefinitely
tissues
mount
effective
responses
antigens.
Cervical
cancer
(CC),
fourth
most
common
cause
cancer-related
mortality
among
women
globally,
experienced
comparatively
limited
progress
delineating
its
microenvironment
compared
other
malignancies.
Notably,
role
tissue-resident
CC
milieu
remains
inadequately
characterized.
This
comprehensive
review
aims
synthesize
current
knowledge
critically
evaluate
putative
roles
these
pathogenesis,
providing
new
insights
on
intricate
dynamics
microenvironment.
