Immune Cell Migration to Cancer DOI Creative Commons
Allison Ryan, Minsoo Kim, Kihong Lim

и другие.

Cells, Год журнала: 2024, Номер 13(10), С. 844 - 844

Опубликована: Май 16, 2024

Immune cell migration is required for the development of an effective and robust immune response. This elegant process regulated by both cellular environmental factors, with variables such as state, anatomical location, disease state that govern differences in patterns. In all cases, a major factor expression surface receptors their cognate ligands. Rapid adaptation to conditions partly depends on intrinsic factors affect cell’s ability adjust new environment. this review, we discuss myeloid lymphoid cells outline key determinants migration, including molecules adhesion, modes chemotaxis, specific chemokine signaling. Furthermore, summarize tumor-specific elements contribute trafficking cancer, while also exploring microenvironment can alter these dynamics within tumor pro antitumor fashion. Specifically, highlight importance secretome later aspects. review considers myriad impact trajectory cancer. We aim immunotherapeutic targets be harnessed achieve controlled tumors.

Язык: Английский

IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer DOI
Nicoletta Caronni, Federica La Terza,

Francesco Maria Vittoria

и другие.

Nature, Год журнала: 2023, Номер 623(7986), С. 415 - 422

Опубликована: Ноя. 1, 2023

Язык: Английский

Процитировано

150

The hallmarks of cancer immune evasion DOI
Claudia Galassi, Timothy A. Chan, Ilio Vitale

и другие.

Cancer Cell, Год журнала: 2024, Номер 42(11), С. 1825 - 1863

Опубликована: Окт. 10, 2024

Язык: Английский

Процитировано

97

Integrative spatial analysis reveals a multi-layered organization of glioblastoma DOI Creative Commons
Alissa C. Greenwald,

Noam Galili Darnell,

Rouven Hoefflin

и другие.

Cell, Год журнала: 2024, Номер 187(10), С. 2485 - 2501.e26

Опубликована: Апрель 22, 2024

Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, proteomics, and computational approaches to define glioma cellular states uncover their organization. We find three prominent modes of First, gliomas are composed small local environments, each typically enriched with one major state. Second, specific pairs preferentially reside proximity across multiple scales. This pairing is consistent tumors. Third, these pairwise interactions collectively a global architecture five layers. Hypoxia appears drive the layers, as it associated long-range organization that includes all cancer cell Accordingly, tumor regions distant from any hypoxic/necrotic foci tumors lack hypoxia such low-grade IDH-mutant less organized. In summary, provide conceptual framework for glioma, highlighting tissue organizer.

Язык: Английский

Процитировано

85

Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives DOI Creative Commons

Hao Lin,

Chaxian Liu,

An-Kang Hu

и другие.

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Май 8, 2024

Abstract Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive microenvironment, thereby confounding conventional therapeutic interventions. Despite established treatment regimen comprising surgical intervention, radiotherapy, temozolomide administration, exploration of emerging modalities such as immunotherapy integration medicine engineering technology therapy, efficacy these approaches remains constrained, resulting in suboptimal prognostic outcomes. In recent years, intensive scrutiny inhibitory milieu within GBM has underscored significance cellular constituents microenvironment their interactions with cells neurons. Novel immune targeted therapy strategies have emerged, offering promising avenues for advancing treatment. One pivotal mechanism orchestrating immunosuppression involves aggregation myeloid-derived suppressor (MDSCs), glioma-associated macrophage/microglia (GAM), regulatory T (Tregs). Among these, MDSCs, though constituting minority (4–8%) CD45 + GBM, play central component fostering evasion propelling tumor progression, angiogenesis, invasion, metastasis. MDSCs deploy intricate mechanisms that adapt dynamic (TME). Understanding interplay between provides compelling basis This review seeks elucidate inherent explore existing targets, consolidate insights into MDSC induction contribution immunosuppression. Additionally, comprehensively surveys ongoing clinical trials potential strategies, envisioning future where targeting could reshape landscape GBM. Through synergistic other modalities, this approach can establish multidisciplinary, multi-target paradigm, ultimately improving prognosis quality life patients

Язык: Английский

Процитировано

76

Cancer cell metabolism and antitumour immunity DOI
Mara De Martino, Jeffrey C. Rathmell, Lorenzo Galluzzi

и другие.

Nature reviews. Immunology, Год журнала: 2024, Номер 24(9), С. 654 - 669

Опубликована: Апрель 22, 2024

Язык: Английский

Процитировано

69

Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma DOI
Alessandra De Leo, Alessio Ugolini, Xiaoqing Yu

и другие.

Immunity, Год журнала: 2024, Номер 57(5), С. 1105 - 1123.e8

Опубликована: Май 1, 2024

Язык: Английский

Процитировано

67

Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization DOI Creative Commons
Wenying Wang, Tianran Li, Yue Cheng

и другие.

Cancer Cell, Год журнала: 2024, Номер 42(5), С. 815 - 832.e12

Опубликована: Апрель 18, 2024

Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes endothelial adherens junctions activating adrenomedullin paracrine signaling, thereby stimulating hyperpermeable neovasculature hampers drug delivery in glioblastoma xenografts. Accordingly, genetic ablation pharmacological blockade produced restores vascular integrity, improves intratumoral concentration anti-tumor agent dabrafenib, achieves combinatorial therapeutic benefits. Increased proportion expression predictive tumor vessel hyperpermeability worse prognosis glioblastoma. Our findings highlight diversity spatial niche-steered reprogramming indicate potential therapeutics targeting normalize vasculature.

Язык: Английский

Процитировано

50

Glioblastoma vaccines: past, present, and opportunities DOI Creative Commons
Zujian Xiong, Itay Raphael, Michael R. Olin

и другие.

EBioMedicine, Год журнала: 2024, Номер 100, С. 104963 - 104963

Опубликована: Янв. 5, 2024

Glioblastoma (GBM) is one of the most lethal central nervous systems (CNS) tumours in adults. As supplements to standard care (SOC), various immunotherapies improve therapeutic effect other cancers. Among them, tumour vaccines can serve as complementary monotherapy or boost clinical efficacy with immunotherapies, such immune checkpoint blockade (ICB) and chimeric antigen receptor T cells (CAR-T) therapy. Previous studies GBM have suggested that few neoantigens could be targeted due low mutation burden, single-peptide vaccination had limited control monotherapy. Combining diverse antigens, including neoantigens, tumour-associated antigens (TAAs), pathogen-derived optimizing vaccine design strategy may help improvement. In this review, we discussed current platforms, evaluated potential antigenic targets, challenges, perspective opportunities for

Язык: Английский

Процитировано

33

Decoding the spatiotemporal heterogeneity of tumor-associated macrophages DOI Creative Commons

Xiangyuan Chu,

Yu Tian, Chao Lv

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 27, 2024

Abstract Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor growth, angiogenesis, and immune evasion. This review explores the spatial temporal heterogeneity of TAMs within microenvironment (TME), highlighting their diverse subtypes, origins, functions. Advanced technologies such as single-cell sequencing multi-omics have elucidated intricate interactions between other TME components, revealing mechanisms behind recruitment, polarization, distribution. Key findings demonstrate that support vascularization, promote epithelial-mesenchymal transition (EMT), modulate extracellular matrix (ECM) remodeling, etc., thereby enhancing invasiveness metastasis. Understanding these complex dynamics offers new therapeutic targets for disrupting TAM-mediated pathways overcoming drug resistance. underscores potential targeting to develop innovative therapies, emphasizing need further research into characteristics functional roles TME.

Язык: Английский

Процитировано

28

Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism DOI Creative Commons
Ronal Peralta, Bingxian Xie, Konstantinos Lontos

и другие.

Nature Immunology, Год журнала: 2024, Номер 25(12), С. 2297 - 2307

Опубликована: Ноя. 8, 2024

Abstract CD8 + T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as cell exhaustion, after persistent receptor stimulation in the tumor microenvironment (TME). Exhausted (T ex ) characterized by upregulation coinhibitory molecules and reduced polyfunctionality. TME experience an immunosuppressive metabolic environment via levels nutrients oxygen buildup lactic acid. Here we show that terminally uniquely upregulate Slc16a11 , which encodes monocarboxylate transporter 11 (MCT11). Conditional deletion MCT11 acid uptake improved their effector function. Targeting with antibody lactate specifically cells, which, when used therapeutically tumor-bearing mice, resulted growth. These data support model MCT11, rendering them sensitive to present at high TME.

Язык: Английский

Процитировано

27