Biomolecules,
Год журнала:
2025,
Номер
15(1), С. 71 - 71
Опубликована: Янв. 6, 2025
The
tumor
microenvironment
(TME)
plays
a
pivotal
role
in
neoplastic
initiation
and
progression.
Epigenetic
machinery,
governing
the
expression
of
core
oncogenes
suppressor
genes
transformed
cells,
significantly
contributes
to
development
at
both
primary
distant
sites.
Recent
studies
have
illuminated
how
epigenetic
mechanisms
integrate
external
cues
downstream
signals,
altering
phenotype
stromal
cells
immune
cells.
This
remolds
area
surrounding
ultimately
fostering
an
immunosuppressive
microenvironment.
Therefore,
correcting
TME
by
targeting
modifications
holds
substantial
promise
for
cancer
treatment.
review
synthesizes
recent
research
that
elucidates
impact
specific
regulations-ranging
from
DNA
methylation
histone
chromatin
remodeling-on
within
TME.
Notably,
we
highlight
their
functional
roles
either
promoting
or
restricting
We
also
discuss
potential
applications
agents
treatment,
envisaging
ability
normalize
ecosystem.
aims
assist
researchers
understanding
dynamic
interplay
between
epigenetics
TME,
paving
way
better
therapy.
The Journal of Experimental Medicine,
Год журнала:
2024,
Номер
221(3)
Опубликована: Фев. 27, 2024
T
cells
are
integral
in
mediating
adaptive
immunity
to
infection,
autoimmunity,
and
cancer.
Upon
immune
challenge,
exit
from
a
quiescent
state,
followed
by
clonal
expansion
effector
differentiation.
These
processes
shaped
three
established
signals,
namely
antigen
stimulation
(Signal
1),
costimulation
2),
cytokines
3).
Emerging
findings
reveal
that
nutrients,
including
glucose,
amino
acids,
lipids,
crucial
regulators
of
cell
responses
interplay
with
Signals
1-3,
highlighting
nutrients
as
Signal
4
license
immunity.
Here,
we
first
summarize
the
functional
importance
underlying
mechanisms
nutrient
transport,
sensing,
signaling
orchestrating
activation
quiescence
exit.
We
also
discuss
roles
programming
differentiation
fitness
how
can
be
targeted
improve
disease
therapy.
Understanding
respond
microenvironments
will
provide
insights
into
context-dependent
functions
therapeutic
interventions.
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
Neutrophils
are
the
most
abundant
innate
immune
cells.
Multiple
mechanisms
allow
them
to
engage
a
wide
range
of
metabolic
pathways
for
biosynthesis
and
bioenergetics
mediating
biological
processes
such
as
development
in
bone
marrow
antimicrobial
activity
ROS
production
NET
formation,
inflammation
tissue
repair.
We
first
discuss
recent
work
on
neutrophil
functions
regulate
granulopoiesis,
migration
trafficking
well
effector
functions.
then
syndromes
with
impaired
that
influenced
by
genetic
environmental
factors
nutrient
availability
usage.
Here,
we
particularly
focus
role
specific
macronutrients,
glucose,
fatty
acids,
protein,
micronutrients
vitamin
B3,
regulating
biology
how
this
regulation
impacts
host
health.
A
special
section
review
primarily
discusses
ways
deficiencies
could
impact
increase
infection
susceptibility.
emphasize
biochemical
approaches
explore
metabolism
relation
Lastly,
opportunities
challenges
neutrophil-centered
therapeutic
immune-driven
diseases
highlight
unanswered
questions
guide
future
discoveries.
Abstract
Cancer
is
one
of
the
leading
causes
death
worldwide,
and
more
effective
ways
attacking
cancer
are
being
sought.
immunotherapy
a
new
therapeutic
method
after
surgery,
radiotherapy,
chemotherapy,
targeted
therapy.
aims
to
kill
tumor
cells
by
stimulating
or
rebuilding
body's
immune
system,
with
specific
efficiency
high
safety.
However,
only
few
patients
respond
due
complex
variable
characters
escape,
behavior
regulatory
mechanisms
need
be
deeply
explored
from
dimensions.
Epigenetic
modifications,
metabolic
modulation,
cell‐to‐cell
communication
key
factors
in
cell
adaptation
response
microenvironment.
They
collectively
determine
state
function
through
modulating
gene
expression,
changing
energy
nutrient
demands.
In
addition,
engage
networks
other
components,
which
mediated
exosomes,
cytokines,
chemokines,
pivotal
shaping
progression
response.
Understanding
interactions
combined
effects
such
multidimensions
modulation
important
for
revealing
failure
developing
targets
strategies.
Diagnostics,
Год журнала:
2024,
Номер
14(7), С. 711 - 711
Опубликована: Март 28, 2024
Four
years
post-pandemic,
SARS-CoV-2
continues
to
affect
many
lives
across
the
globe.
An
estimated
65
million
people
suffer
from
long
COVID,
a
term
used
encapsulate
post-acute
sequelae
of
infections
that
multiple
organ
systems.
Known
symptoms
include
chronic
fatigue
syndrome,
brain
fog,
cardiovascular
issues,
autoimmunity,
dysautonomia,
and
clotting
due
inflammation.
Herein,
we
review
COVID
symptoms,
proposed
theories
behind
pathology,
diagnostics,
treatments,
clinical
trials
underway
explore
treatments
for
viral
persistence,
autonomic
cognitive
dysfunctions,
sleep
disturbances,
fatigue,
exercise
intolerance.
