Extracellular vesicles as nature's nano carriers in cancer therapy: insights toward preclinical studies and clinical applications

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107751 - 107751

Опубликована: Май 1, 2025

Extracellular vesicles (EVs), which are secreted by various cell types, hold significant potential for cancer therapy. However, there several challenges and difficulties that limit their application in clinical settings. This review, integrates the work of our team recent advancements this research field, discusses EV-based treatment strategies to guide application. The following discussed: 1) leveraging inherent properties EVs development treatments; 2) modifying using EV engineering methods improve drug loading delivery; 3) targeting key molecules tumor-derived (TDE) synthesis inhibit production; 4) clearing TDEs from tumor microenvironment. Additionally, on basis into vaccines bispecific antibodies, review elaborates enhance antitumor immunity via modifications can ability stability progress AI technology targeted delivery drugs. Although limited enhancing abilities, provides an in-depth discussion prior studies. Finally, summarizes use therapy highlights need be addressed.

Язык: Английский

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The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Extracellular Vesicles as Precision Therapeutic Vectors: Charting the Future of Cell-Targeted Therapy

Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100031 - 100031

Опубликована: Май 1, 2025

Язык: Английский

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Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Опубликована: Май 22, 2025

ABSTRACT The immune microenvironment includes cells, cytokines, extracellular matrix, vesicles, etc. interactions between these components form a unique local microecology. Although immunity serves as the defense against external pathogens, aberrant activation often contributes to disease development. Chronic diseases, broad category of noncommunicable conditions characterized by long latency and prolonged course, are increasingly recognized for their intricate relationship with microenvironment. Herein, we comprehensively summarize how microenvironment, through its complex regulatory network, influences progression manifestation chronic diseases. We further explore potential targeting therapeutic strategy, aiming provide new insights directions prevention, diagnosis, treatment

Язык: Английский

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Harnessing Exosomes: From Tumor Immune Escape to Therapeutic Innovation in Gastric Cancer Immunotherapy

Cancer Letters, Год журнала: 2025, Номер 626, С. 217792 - 217792

Опубликована: Май 22, 2025

Язык: Английский

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