Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors

Cellular and Molecular Immunology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various malignancies, a large fraction patients are refractory to ICIs employed as standalone therapeutics, necessitating development combinatorial treatment strategies. Immunogenic cell death (ICD) inducers have attracted considerable interest partners for ICIs, at least in part owing their ability initiate tumor-targeting adaptive response. However, compared either approach alone, regimens involving ICD and not always shown superior activity. Here, we discuss accumulating evidence on therapeutic interactions between oncological settings, identify key factors that may explain discrepancies preclinical findings, propose strategies address existing challenges increase efficacy these combinations cancer.

Язык: Английский

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The danger theory of immunity revisited

Nature reviews. Immunology, Год журнала: 2024, Номер 24(12), С. 912 - 928

Опубликована: Ноя. 7, 2024

Язык: Английский

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Microbial molecules, metabolites, and malignancy

Neoplasia, Год журнала: 2025, Номер 60, С. 101128 - 101128

Опубликована: Янв. 18, 2025

Язык: Английский

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Intestinal Microbiome Modulation of Therapeutic Efficacy of Cancer Immunotherapy

Gastroenterology Clinics of North America, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes

Biomolecules, Год журнала: 2025, Номер 15(4), С. 504 - 504

Опубликована: Март 31, 2025

Growing evidence suggests that cancer should not be viewed solely as a genetic disease but also the result of functional defects in metaorganism, including disturbances gut microbiota (i.e., dysbiosis). The human plays critical role regulating epithelial barrier function gut, airways, and skin, along with host metabolism systemic immune responses against microbes cancer. Collaborative international networks, such ONCOBIOME, are essential advancing research equity building microbiome resources to identify validate microbiota-related biomarkers therapies. In this review, we explore intricate relationship between microbiome, metabolism, immunity, propose microbiota-based strategies improve outcomes for individuals at risk developing or living disease.

Язык: Английский

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Two decades of advances in clinical oncology — lessons learned and future directions

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(11), С. 771 - 780

Опубликована: Окт. 1, 2024

Язык: Английский

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