CD4 T cells and B cell help – when exhausted cells can still function

JHEP Reports, Год журнала: 2025, Номер unknown, С. 101435 - 101435

Опубликована: Апрель 1, 2025

Язык: Английский

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Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102519 - 102519

Опубликована: Сен. 1, 2024

Язык: Английский

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Strategies to improve autoimmune neurological diseases treatment

Revue Neurologique, Год журнала: 2024, Номер 180(9), С. 888 - 894

Опубликована: Сен. 19, 2024

There is a need to improve therapies in autoimmune neurologic conditions. Yet which strategic objectives are required, what the barriers that stand before reaching them, and options address them? This article tries summarize these their respective barriers. It discusses difficulties identifying molecular targets, biomarker-defined subgroups, merits of upstream downstream-targeted therapies, develop autoreactivity-specific treatments contrast cell-type specific "evidence-bottleneck". Its focus on autoantigen-specific autoimmunopathies neurology. also role B- T-cells neurology how can be exploited therapeutically. Finally, it argues for improved training present future neuroimmunologists.

Язык: Английский

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Helios—Illuminating the way for lymphocyte self‐control

Immunology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Abstract Transcription factor Helios, encoded by the IKZF2 gene, has an important role in regulatory T cells stabilizing their suppressive phenotype. While Helios is prominently expressed cells, its expression extends beyond to include effector follicular B and innate‐like lymphocyte populations. Recent characterizations of patients with inborn error immunity due damaging variants coupled translational research on lymphocytes from healthy individuals, have increased our understanding Helios' multifaceted controlling human adaptive immune system. A less studied for emerged directing cell maturation. In absence functional acquire more inflammatory phenotype are prone senescence. Loss disrupts regulation germinal centre reaction, often resulting either hypogammaglobulinemia or autoimmunity. This review summarizes findings studies both mice men offering a comprehensive impact transcription

Язык: Английский

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Tricky Ts play possum to propagate autoimmune disease

Science Immunology, Год журнала: 2024, Номер 9(100)

Опубликована: Окт. 4, 2024

Patients with autoimmune disease have exhausted antigen-specific T cells that remain capable of B cell support.

Язык: Английский

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An autoreactive T cell’s perception of a land of plenty

Immunity, Год журнала: 2024, Номер 57(10), С. 2258 - 2260

Опубликована: Окт. 1, 2024

Язык: Английский

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How do autoimmune CD4+ T cells handle exhaustion?

Trends in Immunology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4

Язык: Английский

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The role of allergen-specific regulatory T cells in the control of allergic disease

Current Opinion in Immunology, Год журнала: 2024, Номер 92, С. 102509 - 102509

Опубликована: Дек. 6, 2024

Язык: Английский

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