Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 25, 2025

Язык: Английский

---

Microenvironmental Drivers of Glioma Progression

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2108 - 2108

Опубликована: Фев. 27, 2025

Gliomas, particularly glioblastoma (GBM), are among the most challenging brain tumors due to their complex and dynamic tumor microenvironment (TME). The TME plays a pivotal role in progression, immune evasion, resistance therapy through intricate interactions glioma cells, components, neurons, astrocytes, extracellular matrix, blood-brain barrier. Targeting has demonstrated potential, with immunotherapies such as checkpoint inhibitors neoadjuvant therapies enhancing responses. Nonetheless, overcoming immunosuppressive landscape metabolic adaptations continues pose significant challenges. This review explores diverse cellular molecular mechanisms that shape TME. A deeper understanding of these holds promise for providing novel therapeutic opportunities improve treatment outcomes.

Язык: Английский

---

The Complexity of Malignant Glioma Treatment

Cancers, Год журнала: 2025, Номер 17(5), С. 879 - 879

Опубликована: Март 4, 2025

Malignant glioma is a highly aggressive, therapeutically non-responsive, and deadly disease with unique tumor microenvironment (TME). Of the 14 currently recognized described cancer hallmarks, five are especially implicated in malignant targetable repurposed drugs: stem-like cells, general, cells particular (GSCs), vascularization hypoxia, metabolic reprogramming, tumor-promoting inflammation sustained proliferative signaling. Each hallmark drives development, both individually through interactions other which TME plays critical role. To combat aggressive spatio-temporal heterogeneity driven by interactions, to overcome its therapeutic challenges, combined treatment strategy including anticancer therapies, drugs multimodal immunotherapy should be aim for future approaches.

Язык: Английский

---

Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Introduction H3K27-altered diffuse midline glioma (DMG) is a highly aggressive subtype, accounting for approximately 60% of pediatric high-grade gliomas, with median survival less than 12 months. Due to its predominant localization in the brainstem, conventional surgical resection often unfeasible, underscoring urgent need alternative therapeutic strategies. While previous studies on DMG have primarily focused regulatory mechanisms at protein level, role splicing remains largely unexplored. Given potential impact gene regulation and tumor progression, comprehensive analysis could provide novel insights into targeted or immune strategies, complementing existing transcriptomic DMG. Methods To investigate landscape DMG, we performed transcriptome sequencing (RNA-seq) patient-derived H3WT cell lines, integrating these data RNA-seq single-cell (scRNA-seq) datasets from published sources. This approach enabled us delineate validate distinct features cellular level. Results Our multi-omics revealed significant transcriptional alterations compared particularly pathways related neuro-regulation, metabolism, immunity. Further in-depth identified extensive changes predominantly associated RNA modifications key extracellular matrix nucleotide metabolism. Integrating findings, characterized five RNA-associated proteins that binary classification neural subtypes, each subtype exhibiting prognostic features. Notably, RALYL as regulator progression. Discussion findings indicate exhibits alterations, which play crucial roles tumorigenesis Additionally, our study an RNA-binding protein-based factor, highlighting target.

Язык: Английский

---

Therapeutic approaches for targeting the pediatric brain tumor microenvironment

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Язык: Английский

---

Navigating the mutation maze: An oncogenic driver’s guide to macrophage reprogramming

Immunity, Год журнала: 2024, Номер 57(11), С. 2489 - 2491

Опубликована: Ноя. 1, 2024

Язык: Английский

---