ACS Chemical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Июнь 4, 2025

Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants. Given the prevalence of depression and its associated immune dysregulation, understanding role SSRIs in these processes is crucial. This study aims to explore effects on chronic restraint stress (CRS)-induced depressive-like behaviors functions. Mice subjected CRS were administered citalopram (CITA) during modeling period, followed by behavioral assessments. Histological examination flow cytometry analyze status cells spleen intestine. Cellular experiments performed for verification. We found that CITA treatment significantly alleviated weight loss depression-like mice. Moreover, ameliorated CRS-induced dysregulation reversed decreased villus/crypt ratio ileum. Although had minimal impact restoring intraepithelial lymphocytes after CRS, it reduction innate lymphoid cell type 3 (ILC3) levels. Notably, although levels precursor 5-hydroxytryptophan remained unchanged ileum, tyrosine increased further reduced treatment. Treatment primary ILC3s with 4-ethylphenol, a metabolite, ILC3 their related IL-7 levels, suggesting may be key neurotransmitter regulating through CITA. Hence, effectively ameliorates dysfunctions Tyrosine crucial depression-related intestinal disorders.

Язык: Английский