Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 25, 2025
LRFN4
is
expressed
in
various
tumors
and
leukemia
cell
lines.
This
study
aims
to
explore
the
effect
of
lung
adenocarcinoma
(LUAD).
The
data
on
LUAD
patients
were
collected
from
Cancer
Genome
Atlas
Gene
Expression
Omnibus
database.
expression
lines
was
analyzed
via
differential
gene
analysis,
qRT-PCR
assay,
Western
blotting
assay.
correlation
with
onset
calculated
using
Pearson
analysis.
transcription
factors
correlated
screened
by
analysis
Moreover,
immune
landscape
CIBERSORT
algorithm.
GDSC
CTRP
databases
used
analyze
drug
sensitivity
hub
gene.
highly
cells,
metastasis,
pathological
stages,
age
patients.
E2F1
E2F3
could
regulate
binding
upstream
LRFN4.
8
infiltration
levels
between
high
low
ESTIMATEScore
ImmuneScore
decreased,
TumorPurity
level
elevated,
6
checkpoint
expressions
increased
LRFN4high
had
inferior
prognosis.
mutation
rate
TP53,
TTN,
MUC6
TMB
TCF3,
E2F1,
E2F3,
IC50
multiple
drugs.
may
serve
as
a
novel
prognostic
biomarker
for
LUAD,
shows
specific
overexpression
be
potential
therapeutic
target
Язык: Английский
Chlorogenic acid alleviates DNCB-induced atopic dermatitis by inhibiting the Akt1/NF-κB signaling pathway
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177534 - 177534
Опубликована: Март 1, 2025
Язык: Английский
STAT Signature Dish: Serving Immunity with a Side of Dietary Control
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 487 - 487
Опубликована: Март 26, 2025
Immunity
is
a
fundamental
aspect
of
animal
biology,
defined
as
the
host's
ability
to
detect
and
defend
against
harmful
pathogens
toxic
substances
preserve
homeostasis.
However,
immune
defenses
are
metabolically
demanding,
requiring
efficient
allocation
limited
resources
balance
function
with
other
physiological
developmental
needs.
To
achieve
this
balance,
organisms
have
evolved
sophisticated
signaling
networks
that
enable
precise,
context-specific
responses
internal
external
cues.
These
essential
for
survival
adaptation
in
multicellular
systems.
Central
regulatory
architecture
STAT
(signal
transducer
activator
Transcription)
family,
group
versatile
molecules
govern
wide
array
biological
processes
across
eukaryotes.
demonstrates
remarkable
plasticity,
from
orchestrating
host
defense
mechanisms
regulating
dietary
metabolism.
Despite
its
critical
role,
cell-specific
context-dependent
nuances
remain
incompletely
understood,
highlighting
significant
gap
our
understanding.
This
review
delves
into
emerging
perspectives
on
immunity,
presenting
dynamic
frameworks
explore
complexity
adaptability
underlying
logic
driving
cellular
decision-making.
It
emphasizes
how
pathways
integrate
diverse
processes,
regulation,
ultimately
supporting
organismal
Язык: Английский
The Neuroimmune Axis in Gastrointestinal Disorders – An Underrecognized Problem
Current Gastroenterology Reports,
Год журнала:
2025,
Номер
27(1)
Опубликована: Апрель 15, 2025
Язык: Английский
Cross-regulation between the nervous system and type 2 immunity
Science Immunology,
Год журнала:
2025,
Номер
10(107)
Опубликована: Май 16, 2025
Interactions
between
the
nervous
and
immune
systems
are
critical
to
healthy
physiology
altered
in
many
human
diseases.
Many
of
major
players
type
2
responses,
including
lymphocytes
cytokines,
mast
cells,
immunoglobulin
E,
have
been
implicated
neuronal
function
behavior.
Conversely,
neurons
both
central
peripheral
can
affect
responses
behaviors
relevant
allergy,
such
as
food
avoidance.
Defining
this
complex
circuitry
its
molecular
intermediates
may
reveal
immunomodulators
that
be
harnessed
for
therapeutic
benefit
neurologic
diseases
Alzheimer’s
disease,
brain
injury,
neurodevelopmental
disorders.
modulation
system
an
important
adjunct
treating
immunologic
disorders
atopic
dermatitis,
asthma,
allergy.
This
Review
covers
recent
work
defining
how
regulate
regulated
by
responses.
Язык: Английский