Combination of radiotherapy and ICIs in advanced hepatocellular carcinoma: A systematic review of current evidence and future prospects (Review) DOI Open Access
Cheng Ma,

Xinlin Yu,

Xialin Zhang

и другие.

Oncology Letters, Год журнала: 2025, Номер 30(1), С. 1 - 15

Опубликована: Май 14, 2025

Hepatocellular carcinoma (HCC) is a global health concern because of its rising prevalence and high fatality rates. Conventional treatments for advanced HCC (aHCC) have limited success, emphasizing the need novel treatment options. Radiotherapy (RT) treatments, such as stereotactic body radiation proton therapy, improve local tumor management via precision targeting. Moreover, immune checkpoint inhibitors (ICIs) that target programmed cell death protein 1(PD-1)/PD ligand 1 (PD-L1) cytotoxic T lymphocyte associated 4 (CTLA-4) pathways promise systemic antitumor effectiveness. The combination RT ICIs takes advantage their complementary mechanisms: kills immunogenic cells controls microenvironment to increase antigen presentation, whereas enhance maintain responses. This enhances regression response in aHCC, improving rate progression-free survival with manageable safety. present review aimed summarize rationale combining + patients aHCC clinical outcomes, well ways this technique. these models promising technique outcomes warrants further investigation.

Язык: Английский

Treg cells augment self-tolerance during infection DOI
Ryoji Kawakami, Shimon Sakaguchi

Nature Immunology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
Autoimmune Pancreatitis: A Review DOI Open Access

Varun Vemulapalli,

Cristina Natha, Anusha Shirwaikar Thomas

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(9), С. 3076 - 3076

Опубликована: Апрель 29, 2025

Autoimmune pancreatitis is a rare condition of pancreatic inflammation with two classic subtypes. The emergence third subtype, ICI-induced pancreatitis, highlights the need for knowledge each type to ensure accurate diagnosis and treatment. Abbreviations: AIP-Autoimmune pancreatitis; AIP-1-Type 1 autoimmune also known as lymphoplasmacytic sclerosing (LPSP); AIP-2-Type 2 referred idiopathic duct-centric (IDCP); AIP-3-Type 3 immune checkpoint inhibitor (ICI)-induced IgG4-RD-Immunoglobulin G4-related disease.

Язык: Английский

Процитировано

0
Combination of radiotherapy and ICIs in advanced hepatocellular carcinoma: A systematic review of current evidence and future prospects (Review) DOI Open Access
Cheng Ma,

Xinlin Yu,

Xialin Zhang

и другие.

Oncology Letters, Год журнала: 2025, Номер 30(1), С. 1 - 15

Опубликована: Май 14, 2025

Hepatocellular carcinoma (HCC) is a global health concern because of its rising prevalence and high fatality rates. Conventional treatments for advanced HCC (aHCC) have limited success, emphasizing the need novel treatment options. Radiotherapy (RT) treatments, such as stereotactic body radiation proton therapy, improve local tumor management via precision targeting. Moreover, immune checkpoint inhibitors (ICIs) that target programmed cell death protein 1(PD-1)/PD ligand 1 (PD-L1) cytotoxic T lymphocyte associated 4 (CTLA-4) pathways promise systemic antitumor effectiveness. The combination RT ICIs takes advantage their complementary mechanisms: kills immunogenic cells controls microenvironment to increase antigen presentation, whereas enhance maintain responses. This enhances regression response in aHCC, improving rate progression-free survival with manageable safety. present review aimed summarize rationale combining + patients aHCC clinical outcomes, well ways this technique. these models promising technique outcomes warrants further investigation.

Язык: Английский

Процитировано

0