Abstract
Plastic
waste
is
ubiquitously
present
across
the
world,
and
its
nano/sub‐micron
analogues
(plastic
nanoparticles,
PNPs),
raise
severe
environmental
concerns
affecting
organisms’
health.
Considering
direct
indirect
toxic
implications
of
PNPs,
their
biological
impacts
are
actively
being
studied;
lately,
with
special
emphasis
on
cellular
molecular
mechanistic
intricacies.
Combinatorial
OMICS
studies
identified
proteins
as
major
regulators
PNP
mediated
toxicity
via
activation
oxidative
enzymes
generation
ROS.
Alteration
protein
function
by
PNPs
results
in
DNA
damage,
organellar
dysfunction,
autophagy,
thus
resulting
inflammation/cell
death.
The
basis
these
endeavors
fine‐tuned
at
level
structural
alterations
physiological
relevance.
Detailed
biophysical
such
protein‐PNP
interactions
evidenced
prominent
modifications
architecture
conformational
energy
landscape.
Another
essential
aspect
includes
bioenzymatic
plastic
degradation
perspective,
interactive
units
plastics
essentially
nano‐sized.
Combining
all
attributes
interactions,
current
review
comprehensively
documented
contemporary
understanding
concerned
light
cellular,
molecular,
kinetic/thermodynamic
details.
Additionally,
applicatory,
economical
facet
biogeochemical
cycle
enzymatic
advances
pertaining
to
has
also
been
discussed.
Particle and Fibre Toxicology,
Год журнала:
2023,
Номер
20(1)
Опубликована: Ноя. 22, 2023
Microplastics
and
nanoplastics
(MNPs)
are
emerging
environmental
contaminants
detected
in
human
samples,
have
raised
concerns
regarding
their
potential
risks
to
health,
particularly
neurotoxicity.
This
study
aimed
investigate
the
deleterious
effects
of
polystyrene
(PS-NPs,
50
nm)
understand
mechanisms
inducing
Parkinson's
disease
(PD)-like
neurodegeneration,
along
with
exploring
preventive
strategies.
RSC Advances,
Год журнала:
2023,
Номер
13(45), С. 31435 - 31459
Опубликована: Янв. 1, 2023
Micronanoplastics
(MNPs)
interact
with
blood
components,
resulting
in
anemia,
cardiovascular
diseases,
etc.
Research
gaps
include
toxic
impacts
of
real-world
MNPs,
monomers,
co-pollutants
complex,
and
so
on,
emphasizing
the
need
for
more
research.
Abstract
Secondary
nanoplastics
(NPs)
caused
by
degradation
and
aging
due
to
environmental
factors
are
the
main
source
of
human
exposure,
alterations
in
physicochemical
biological
properties
NPs
induced
cannot
be
overlooked.
In
this
study,
pristine
polystyrene
(PS)
obtain
ultraviolet
(UV)‐aged
PS
(aPS
NPs)
as
secondary
is
artificially
aged.
a
mouse
oral
exposure
model,
nephrotoxicity
aPS
compared,
results
showed
that
more
serious
destruction
kidney
tissue
structure
function,
along
with
characteristic
changes
ferroptosis.
Subsequent
vitro
experiments
revealed
NPs‐induced
cell
death
renal
tubular
epithelial
cells
involved
ferroptosis,
which
supported
use
ferrostatin‐1,
ferroptosis
inhibitor.
Notably,
it
discovered
can
enhance
binding
serum
transferrin
(TF)
its
receptor
on
membrane
forming
an
aPS‐TF
complex,
leading
increase
intracellular
Fe
2+
then
exacerbation
oxidative
stress
lipid
peroxidation,
render
sensitive
These
findings
indicated
UV
irradiation
alter
NPs,
enhancing
their
toxicity
risk
inducing
Biophysical Chemistry,
Год журнала:
2024,
Номер
308, С. 107213 - 107213
Опубликована: Фев. 27, 2024
Micro-
and
nanoplastics
have
become
a
significant
concern,
due
to
their
ubiquitous
presence
in
the
environment.
These
particles
can
be
internalized
by
human
body
through
ingestion,
inhalation,
or
dermal
contact,
then
they
interact
with
environmental
biological
molecules,
such
as
proteins,
resulting
formation
of
protein
corona.
However,
information
on
role
corona
is
still
missing.
Coarse-grain
models
pentapeptides
were
created
simulated
at
microscale
study
Additionally,
lipid
bilayer
coarse-grain
model
was
reproduced
investigate
behavior
coronated
proximity
bilayer.
Hydrophobic
aromatic
amino
acids
high
tendency
create
stable
bonds
all
nanoplastics.
Moreover,
polystyrene
polypropylene
establish
polar
charged
acids.
When
are
close
bilayer,
different
behaviors
observed.
Polyethylene
creates
single
polymeric
chain,
while
tends
break
down
into
its
chains.
Polystyrene
both
separate
individual
chains
remain
aggregated.
The
plays
an
important
when
interacting
membrane.
More
studies
needed
validate
results
enhance
complexity
systems.
