International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140064 - 140064
Опубликована: Янв. 1, 2025
Curcumin,
a
hydrophobic
drug
derived
from
the
rhizome
of
Curcuma
longa,
exhibits
significant
bioactive
properties,
including
antioxidant
and
antimicrobial
potential.
However,
its
poor
water
solubility
rapid
degradation
limit
practical
applications.
This
study
presents
novel
design
electrospun
nanofibers
using
Curcumin/hydroxypropyl-β-cyclodextrin
inclusion
complex
(HP-β-CD-IC)
combined
with
pullulan
to
enhance
thermal
stability
controlled
release.
In
uniaxial
nanofibers,
curcumin/HP-β-CD-IC
is
uniformly
distributed,
whereas
in
coaxial
serves
as
core
material,
wall
material.
X-ray
diffraction
Fourier-transform
infrared
spectroscopy
confirmed
successful
formation,
fibers
showing
no
crystalline
peaks
curcumin.
Differential
scanning
calorimetry
indicated
enhanced
stability,
melting
points
shifting
279.19
°C
291.63
for
fibers,
respectively.
Scanning
electron
microscopy
transmission
verified
core-shell
structure
uniform
morphology.
vitro
release
studies
revealed
that
achieved
higher
cumulative
(93
±
1.41
%)
compared
(80
2.82
over
350
min.
Antibacterial
tests
demonstrated
improved
activity
against
S.
aureus
E.
coli.
Addressing
critical
need
stable
bioavailable
delivery
compounds,
this
innovative
nanofiber
holds
great
promise
revolutionizing
applications
food
technology
delivery.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
In
our
pursuit
of
novel
succinate
dehydrogenase
inhibitor
(SDHI)
fungicides
for
agriculture,
we
replaced
the
traditional
amide
structure
with
a
sulfonamide
framework
and
introduced
various
heterocyclic
aromatic
rings
at
sulfonamide's
termini.
This
strategy
yielded
30
synthesized
compounds,
which
were
screened
antifungal
activity
against
eight
phytopathogenic
fungi.
The
biological
assay
results
demonstrated
that
several
target
compounds
exhibited
significant
in
vitro
activity.
Notably,
compound
2f
showed
remarkable
Valsa
mali
an
EC50
value
0.56
mg/L,
outperforming
Boscalid
(EC50
=
1.79
mg/L).
vivo
experiments
revealed
provided
protection
to
apple
fruits,
comparable
Boscalid.
SEM
analysis
3e
disrupted
morphology
fungal
hypha
analysis,
suggested
terminal
polyhalogen-substituted
pyridine
moieties
might
be
pivotal
regions
influencing
their
efficacy.
Molecular
docking
binding
mode
SDH.
Furthermore,
detailed
SDH
inhibition
assays
confirmed
potential
(IC50
2.51
μM)
as
prospective
inhibitors.
RNA
transcriptomic
indicated
application
could
influence
gene
expression
fungi,
thereby
exerting
defensive
effect
plant
pathogenic
Consequently,
shows
promise
developing
efficient
agrochemical
fungicide.
The
development
of
hydrophobic
pesticide
formulations
remains
constrained
by
complicated
manufacturing
processes,
excessive
reliance
on
organic
solvents,
and
indispensable
surfactants.
practical
application
dimethomorph
(DIM)
is
hindered
its
nature,
posing
risks
to
nontarget
organisms.
Inspired
the
uptake
nanomaterials
plants,
DIM
was
encapsulated
in
cyclodextrin
(CD)
cavity
optimize
water-solubility
sustained-release
rate.
spatial
confinement
effect
CD
could
facilitate
thermostability
DIM.
DIM/CD
inclusion
complex
solutions
were
electrospun
fabricate
nanofibers
with
bead-free
smooth
morphology.
As
predicted,
release
reached
plateaus
accumulative
values
approximately
75%.
antifungal
activity
possesses
much
higher
than
for
controlling
Rhizoctonia
solani
Haematonectria
hematococco,
thereby
enhancing
bioactivity
reducing
spraying
frequency.
inhibition
rates
DIM/HPβCD
DIM/HPγCD
are
found
be
55.8%
53.6%
within
144
h,
respectively.
This
work
explores
feasibility
as
a
delivery
platform
sustained
agriculture
production.
Abstract
Butylated
hydroxytoluene
(BHT)
and
butylated
hydroxyanisole
(BHA)
are
synthetic
phenolic
antioxidants
widely
used
as
additives
in
the
food
industry.
In
this
context,
beta‐cyclodextrin
(βCD)
appears
a
suitable
encapsulating
agent
due
to
its
bioavailability,
water
solubility,
high
efficacy
incorporating
compounds.
The
inclusion
complexes
(ICs)
prepared
via
co‐precipitation
method,
followed
by
freeze‐drying.
1
H
NMR
FTIR
confirm
formation
of
ICs.
Molecular
modeling,
including
molecular
docking
dynamics
(MD)
simulations,
is
conducted
investigate
interactions
involved
ICs
their
thermodynamic
stability,
respectively.
Furthermore,
effect
on
antioxidant
evaluated
through
scavenging
capacity
DPPH.
spectroscopic
methods
confirmed
that
BHT
BHA
successfully
incorporated
into
βCD.
revealed
hydrogen
bonds,
with
binding
energies
−5.76
−5.16
kcal
mol
−1
for
BHT/βCD
BHA/βCD,
After
performing
MD
simulations
100
ns,
both
demonstrated
degree
stability
over
time.
DPPH
assay
showed
an
increase
ability
(IC
50
decreased
from
68.82
53.32
µg
mL
)
but
decrease
efficiency
increased
451.25
598.36
).
