Hydroxyapatite modified poly(acrylic acid)/polyethylene glycol sustainable drug delivery nanocomposite prepared via double emulsion with bitter almond oil
Sustainable Chemistry and Pharmacy,
Год журнала:
2024,
Номер
38, С. 101497 - 101497
Опубликована: Фев. 21, 2024
A
sustainable
hydrogel-based
drug
delivery
system
for
pH-sensitive
of
doxorubicin
(DOX)
as
a
model
has
been
developed
the
first
time
to
address
some
complications
chemotherapy.
The
biobased
nanocomposite
comprising
hydroxyapatite
(HAP)
nanoparticles
loaded
in
biodegradable
poly(acrylic
acid)
(PAA)/polyethylene
glycol
(PEG)
hydrogel
network
was
prepared
via
double
emulsion
method
using
bitter
almond
oil
and
span
80
surfactant.
Double
emulsions
can
expand
release
drugs
longer
period
well
increase
their
bioavailability
tumor
tissues.
Multiple
analyses
were
conducted
assess
structure
nanocarriers
therapeutic
efficiency.
XRD
FTIR
corroborated
successful
synthesis
gave
insight
into
crystalline
nature
molecular
interactions
between
components.
DLS
revealed
monodispersity
nanocarriers,
with
an
average
size
418
nm.
TEM
SEM
showed
spherical
porous
morphology
zeta
potential
measurements
indicated
surface
charge
−34.5
mV,
thus
corroborating
excellent
stability
suitability
long
storage.
loading
entrapment
efficiencies
(46%
87.5%,
respectively)
higher
than
those
reported
previously
similar
nanocarriers.
An
effective
sustained
profile
observed
at
pH
5.4.
MMT
assay
flow
cytometric
that
satisfactory
cytotoxicity
compared
free
DOX.
Язык: Английский
Advances in stimuli-responsive polymeric hydrogels for anticancer drug delivery: A review
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
102, С. 106394 - 106394
Опубликована: Ноя. 8, 2024
Язык: Английский
Solvothermal synthesis of hematite (α-Fe2O3) nanoparticles: Influence of surfactants on morphology, magnetic anisotropy, MRI relaxivity and biocompability
Inorganic Chemistry Communications,
Год журнала:
2025,
Номер
unknown, С. 114290 - 114290
Опубликована: Март 1, 2025
Язык: Английский
Nanotechnology revolutionizing osteosarcoma treatment: Advances in targeted kinase inhibitors
Nanotechnology Reviews,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 1, 2025
Abstract
Osteosarcoma
(OS)
is
the
most
frequent
primary
malignant
bone
tumor
in
adolescents
and
young
adults.
Despite
advances
therapy,
OS
remains
an
ominous
problem
because
of
its
high
metastatic
potential,
resistance
to
standard
great
physical,
psychological,
financial
burden
on
patients.
Available
treatment
options
like
surgery
high-dose
chemotherapy
are
limited
by
chemotoxicity,
multimed
resistance,
adverse
effects
quality
life
Extrapolated
from
wide
array
vitro
vivo
studies,
application
kinase
inhibitors
targeting
oncogenic
signaling
pathways,
such
as
insulin-like
growth
factor
1
receptor,
PDGFR,
PI3K/AKT/mTOR
pathway,
appears
quite
promising.
However,
patients
plagued
with
challenges
poor
bioavailability,
off-target
effects,
mechanisms,
which
prevent
clinical
application.
This
review
explores
how
nanotechnology
beginning
meet
these
challenges.
Liposomes,
polymeric
nanoparticles,
metallic
nanoparticles
among
that
provide
new
solutions
for
delivery
bioavailability
inhibitors,
reducing
systemic
toxicity
enhancing
therapeutic
accuracy.
Active
or
passive
enabled
nanocarriers,
enable
drugs
specifically
act
tissues
while
minimizing
healthy
cells.
Additionally,
diagnostic
functionalities
combined
into
theranostic
platforms
through
pave
way
personalized
medicine
approaches.
Nanoparticle-based
have
shown
efficacy
preclinical
setting
overcome
drug
improve
targeting,
sustained
release
drug.
These
dramatic
improving
outcomes
at
much
less
than
currently
available
treatments.
shows
need
further
exploration
bridge
exciting
findings
practice.
Future
studies
should
seek
optimize
nanoparticle
design
evade
enhance
target
specificity,
reduce
time-dependent
toxicity.
Further,
incorporation
a
strategy
has
possibility
changing
treated
bringing
promise
better
patient
life.
Язык: Английский
The impact of pH value on the transfer and release dynamics of doxorubicin facilitated by carbon nanotubes within the capillary network surrounding cancerous tumors through molecular dynamics simulation
Results in Chemistry,
Год журнала:
2024,
Номер
unknown, С. 101769 - 101769
Опубликована: Сен. 1, 2024
Язык: Английский