Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Язык: Английский

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Fabrication of Carbon Quantum Dots by Microemulsion Route: Dual Functional Materials for Energy Storage and Environmental Treatment

Materials Research Bulletin, Год журнала: 2025, Номер unknown, С. 113494 - 113494

Опубликована: Апрель 1, 2025

Язык: Английский

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2D/0D Heterojunction Fluorescent Probe with Schottky Barrier Based on Ti₃C₂T_X MXene Loaded Graphene Quantum Dots for Detection of H₂S During Food Spoilage

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Abstract Hydrogen sulfide (H 2 S) contamination of food has raised widespread public health concerns, leading to substantial medical and economic burdens. Herein, a 2D/0D heterojunction fluorescent probe (TCTG) with Schottky barriers (SB) is designed synthesized, utilizing Ti 3 C T x MXene‐loaded graphene quantum dots (GQDs), for the detection H S during spoilage. The microstructures observed through SEM TEM reveal that uniformly sized GQDs are evenly attached surface monolayer . chemisorption between facilitates charge transfer formation SB, resulting in intramolecular (ICT) effects. With introduction S, TCTG (50%) exhibits highest sensitivity, selectivity, anti‐interference properties, ultra‐fast fluorescence transient reaction (3s) remarkably low limit 41.82 ppb as well noticeable color change. When reacted ICT effects inhibited, recovery photoinduced electron (PET) quenching. Notably, effectively utilized detect changes levels raw foods assess their quality. Overall, significance this study its potential revolutionize spoilage detection, offering fast, reliable, sensitive method ensure safety reduce associated

Язык: Английский

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Crafting carbon quantum dots from acetone: dual purpose Fe3+ ion and pH sensing platform

Emergent Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Язык: Английский

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Nanomaterial-Based Biosensors for Early Detection of Mpox Virus: A Comprehensive Analysis

Sensors and Actuators Reports, Год журнала: 2024, Номер unknown, С. 100263 - 100263

Опубликована: Ноя. 1, 2024

Язык: Английский

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Biocompatibility, biodegradability, and toxicity evaluations of chitosan nanoparticles

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 139 - 187

Опубликована: Ноя. 29, 2024

Язык: Английский

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Recycling and breakdown photodegradation processes cost of BEN-TiQD via different photodegradation processes of Brilliant Green S dye and industrial effluents.

Ceramics International, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Optical Performance of Quantum Dots and Their Applications in Biomedical Imaging

Science and Technology of Engineering Chemistry and Environmental Protection, Год журнала: 2024, Номер 1(9)

Опубликована: Окт. 29, 2024

Quantum dots are nanomaterials which have attracted significant focus over the past few years because of their singular optical features. They shown great potential in field bioimaging. This study delves into photonic properties quantum include good luminescence stability and broad excitation spectra. Besides, emission wavelength can be precisely controlled. These make them an excellent choice for bio-imaging. The usage live organism imaging, such as pinpointing cell boundaries, tracking intracellular molecular dynamics, early disease diagnosis, indicate immense biomedical realm. Through modifications on surface dots, targeted imaging realized, greatly improves specificity sensitivity imaging. Nonetheless, biosafety long-term vivo behavior still need to further investigated. Overall, light-based attributes brought breakthroughs bio-imaging technology. In addiiton, it would foretell a bright future field.

Язык: Английский

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Preparation of High Quantum Yield Nitrogen-Doped Carbon Quantum Dots Via Solid-Phase Pyrolysis for Highly Sensitive "Off-On" Fluorescence Probe Detection of Glutathione and Cellular Imaging Studies

Опубликована: Янв. 1, 2024

Язык: Английский

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