Cell Death and Disease,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 5, 2025
The
tumor
microenvironment
(TME)
plays
an
important
role
in
tumorigenesis
and
development.
Tumor-associated
macrophages
(TAMs)
are
essential
members
of
the
TME,
exosomes
miRNAs
they
secrete
crucial
regulation.
Our
previous
study
showed
that
GRP78-induced
infinitely
tend
to
be
M2-type
TAMs.
In
this
study,
M0
macrophage
were
collected
co-incubated
with
colorectal
cancer
(CRC)
cells.
results
implied
induced
by
GRP78
(GRP78-exos)
significantly
promoted
stemness
chemoresistance
CRC
vitro
vivo.
Further,
top
5
upregulated
GRP78-exos
obtained
from
miRNA
sequencing
data.
qRT-PCR
validation
revealed
miR-769-5p
was
most
observably
could
directly
transferred
into
cells
via
GRP78-exos.
Mechanistically,
indicated
targeted
MAPK1
regulate
cell
cycle-related
proteins
RB1,
cyclin
D1,
E1.
This
contributes
entering
a
quiescent
state,
which
leads
development
chemoresistance.
Moreover,
is
also
expressed
higher
tissues
5-FU-resistant
patients.
summary,
findings
indicate
novel
function
as
potential
marker
for
diagnosis
treatment
chemotherapy
resistance
CRC.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 5, 2024
Abstract
Cancer
stem
cells
(CSCs),
a
small
subset
of
in
tumors
that
are
characterized
by
self-renewal
and
continuous
proliferation,
lead
to
tumorigenesis,
metastasis,
maintain
tumor
heterogeneity.
continues
be
significant
global
disease
burden.
In
the
past,
surgery,
radiotherapy,
chemotherapy
were
main
cancer
treatments.
The
technology
treatments
develop
advance,
emergence
targeted
therapy,
immunotherapy
provides
more
options
for
patients
certain
extent.
However,
limitations
efficacy
treatment
resistance
still
inevitable.
Our
review
begins
with
brief
introduction
historical
discoveries,
original
hypotheses,
pathways
regulate
CSCs,
such
as
WNT/β-Catenin,
hedgehog,
Notch,
NF-κB,
JAK/STAT,
TGF-β,
PI3K/AKT,
PPAR
pathway,
their
crosstalk.
We
focus
on
role
CSCs
various
therapeutic
outcomes
resistance,
including
how
affect
content
alteration
related
molecules,
CSCs-mediated
clinical
value
targeting
refractory,
progressed
or
advanced
tumors.
summary,
efficacy,
method
is
difficult
determine.
Clarifying
regulatory
mechanisms
biomarkers
currently
mainstream
idea.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 14
Опубликована: Апрель 11, 2022
Thioredoxin-interacting
protein
(TXNIP)
was
originally
named
vitamin
D3
upregulated
protein-1
(VDUP1)
because
of
its
ability
to
bind
thioredoxin
(TRX)
and
inhibit
TRX
function
expression.
TXNIP
is
an
alpha-arrestin
that
essential
for
redox
homeostasis
in
the
human
body.
may
act
as
a
double-edged
sword
cell.
The
balance
crucial.
A
study
has
shown
can
travel
between
diverse
intracellular
locations
different
proteins
play
roles
under
oxidative
stress.
primary
induce
apoptosis
or
pyroptosis
also
inhibits
proliferation
migration
cancer
cells,
although
levels
decrease,
diminishes
various
cancers.
In
this
review,
we
summarized
main
structure,
binding
proteins,
pathways,
role
diseases,
aiming
explore
TXNIP,
expect
it
be
helpful
future
treatment
using
therapeutic
target.
Experimental Hematology and Oncology,
Год журнала:
2024,
Номер
13(1)
Опубликована: Авг. 1, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
a
highly
heterogeneous
malignancy
with
high
incidence,
recurrence,
and
metastasis
rates.
The
emergence
of
immunotherapy
has
improved
the
treatment
advanced
HCC,
but
problems
such
as
drug
resistance
immune-related
adverse
events
still
exist
in
clinical
practice.
immunosuppressive
tumor
microenvironment
(TME)
HCC
restricts
efficacy
essential
for
progression
metastasis.
Therefore,
it
necessary
to
elucidate
mechanisms
behind
TME
develop
apply
immunotherapy.
This
review
systematically
summarizes
pathogenesis
formation
TME,
by
which
accelerates
We
also
status
further
discuss
existing
challenges
potential
therapeutic
strategies
targeting
TME.
hope
inspire
optimizing
innovating
immunotherapeutic
comprehensively
understanding
structure
function
HCC.
British Journal of Cancer,
Год журнала:
2023,
Номер
129(12), С. 1877 - 1892
Опубликована: Окт. 4, 2023
Abstract
Thioredoxin-interacting
protein
(TXNIP)
is
commonly
considered
a
master
regulator
of
cellular
oxidation,
regulating
the
expression
and
function
Thioredoxin
(Trx).
Recent
work
has
identified
that
TXNIP
far
wider
range
additional
roles:
from
glucose
lipid
metabolism,
to
cell
cycle
arrest
inflammation.
Its
increased
by
stressors
found
in
neoplastic
cells
tumor
microenvironment
(TME),
and,
as
such,
been
extensively
studied
cancers.
In
this
review,
we
evaluate
current
literature
regarding
regulation
TXNIP,
highlighting
its
emerging
role
modulating
signaling
between
different
types
within
TME.
We
then
assess
future
translational
opportunities
associated
challenges
area.
An
improved
understanding
functions
mechanisms
cancers
may
enhance
suitability
therapeutic
target.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(7)
Опубликована: Июль 12, 2024
The
tumor
microenvironment
is
a
complex
space
comprised
of
normal,
cancer
and
immune
cells.
macrophages
are
considered
as
the
most
abundant
cells
in
their
function
tumorigenesis
interesting.
Macrophages
can
be
present
M1
M2
polarization
that
show
anti-cancer
oncogenic
activities,
respectively.
Tumor-associated
(TAMs)
mainly
have
they
increase
due
to
secretion
factors,
cytokines
affecting
molecular
pathways.
Hepatocellular
carcinoma
(HCC)
among
predominant
tumors
liver
spite
understanding
its
pathogenesis,
role
progression
still
requires
more
attention.
presence
TAMs
HCC
causes
an
growth
invasion
one
reasons
induction
glycolysis
such
metabolic
reprogramming
makes
distinct
from
normal
promotes
malignancy.
Since
stimulates
HCC,
networks
regulating
conversion
been
highlighted
moreover,
drugs
compounds
with
ability
targeting
suppressing
phenotypes
or
at
least
activity
utilized.
aggressive
behavior
biological
functions
result
development
therapy
resistance.
provide
cell-cell
communication
by
secreting
exosomes
having
various
types
biomolecules
transfer
change
activity.
Finally,
non-coding
RNA
transcripts
affect
HCC.
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 778 - 778
Опубликована: Июнь 27, 2024
Antioxidants
play
a
pivotal
role
in
neutralizing
reactive
oxygen
species
(ROS),
which
are
known
to
induce
oxidative
stress.
In
the
context
of
cancer
development,
cells
adeptly
maintain
elevated
levels
both
ROS
and
antioxidants
through
process
termed
"redox
reprogramming".
This
balance
optimizes
proliferative
influence
while
simultaneously
reducing
potential
for
cause
damage
cell.
some
cases,
adapted
antioxidant
machinery
can
hamper
efficacy
treatments
neoplastic
diseases,
representing
significant
facet
resistance
mechanisms
observed
therapy.
this
review,
we
outline
contribution
systems
therapeutic
resistance.
We
detail
fundamental
constituents
these
systems,
encompassing
central
regulatory
involving
transcription
factors
(of
particular
importance
is
KEAP1/NRF2
signaling
axis),
molecular
effectors
antioxidants,
auxiliary
responsible
NADPH
generation.
Furthermore,
present
recent
clinical
trials
based
on
targeted
treatment
cancer,
assessing
as
well
challenges
strategy
Additionally,
summarize
pressing
issues
field,
with
aim
illuminating
path
toward
emergence
novel
anticancer
approaches
by
orchestrating
redox
signaling.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 9, 2024
Abstract
Tumor
cells
primarily
employ
the
PD-1/PD-L1
pathway
to
thwart
anti-tumor
capabilities
of
T
lymphocytes,
inducing
immunosuppression.
This
occurs
through
direct
interaction
PD-L1
with
PD-1
on
lymphocyte
surfaces.
Recent
research
focusing
tumor
microenvironment
has
illuminated
pivotal
role
immune
cells,
particularly
tumor-associated
macrophages
(TAMs),
in
facilitating
PD-L1-mediated
Exosomes,
characterized
by
their
ability
convey
information
and
be
engulfed
significantly
contribute
promoting
TAM
involvement
establishing
immunosuppression
within
microenvironment.
In
addition
receiving
signals
from
tumor-derived
exosomes
that
promote
expression,
TAMs
also
exert
control
over
expression
release
exosomes.
paper
aims
summarize
mechanisms
which
participate
this
process,
identify
crucial
factors
influence
these
mechanisms,
explore
innovative
strategies
for
inhibiting
or
reversing
tumor-promoting
effects
targeting
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 22, 2024
Abstract
Cancer
stem
cells
(CSCs)
represent
a
small
yet
pivotal
subset
of
tumor
endowed
with
self-renewal
capabilities.
These
are
intricately
linked
to
progression
and
central
drug
resistance,
metastasis,
recurrence.
The
microenvironment
(TME)
encompasses
the
cancer
their
surrounding
milieu,
including
immune
inflammatory
cells,
cancer-associated
fibroblasts,
adjacent
stromal
tissues,
vasculature,
variety
cytokines
chemokines.
Within
TME,
such
as
endothelial
adipocytes,
fibroblasts
release
growth
factors,
cytokines,
chemokines,
exosomes,
which
can
either
sustain
or
disrupt
CSCs,
thereby
influencing
progression.
Conversely,
CSCs
also
secrete
affecting
various
components
TME.
Exosomes,
extracellular
vesicles
(EVs),
carry
complex
cargo
nucleic
acids,
proteins,
lipids,
playing
crucial
role
in
communication
between
This
review
primarily
focuses
on
impact
exosomes
secreted
by
(CSC-exo)
progression,
roles
maintaining
stemness,
promoting
angiogenesis,
facilitating
inducing
suppression,
contributing
resistance.
Additionally,
we
discuss
how
different
within
TME
affect
CSCs.
Finally,
explore
potential
utilizing
mitigate
detrimental
effects
target
eliminate
them.
A
thorough
understanding
exosome-mediated
crosstalk
could
provide
valuable
insights
for
developing
targeted
therapies
against
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 4, 2023
Intervertebral
disc
degeneration
(IVDD)
is
a
major
contributor
to
spinal
disorders.
Previous
studies
have
indicated
that
the
infiltration
of
immunocytes,
specifically
macrophages,
plays
crucial
role
in
advancement
IVDD.
Exosomes
(exo)
are
believed
play
significant
intercellular
communication.
This
study
aims
investigate
exosomes
derived
from
degenerated
nucleus
pulposus
(dNPc)
process
macrophages
M1
polarization.Nucleus
(NP)
tissue
and
cells
(NPc)
were
collected
patients
with
intervertebral
idiopathic
scoliosis.
Immunohistochemistry
analysis
was
performed
determine
number
NP
tissue.
Subsequently,
(dNPc-exo)
non-degenerated
(nNPc-exo)
co-cultured
M0
which
induced
THP-1
cells.
The
phenotype
assessed
using
western
blot,
flow
cytometry,
immunofluorescence
staining,
qRT-PCR.
RNA-sequencing
conducted
examine
expression
levels
microRNAs
dNPc-exo
nNPc-exo
groups,
qRT-PCR
effect
pf
different
microRNA
induce
macrophage
polarization.
Furthermore,
blot
employed
demonstrate
regulatory
carried
by
on
downstream
target
signaling
pathways
macrophages.
Finally,
an
animal
model
IVDD
utilized
impact
inducing
polarization
its
process.In
this
study,
we
observed
increase
as
(IVD)
degraded.
Additionally,
discovered
dNPc
releases
could
promote
towards
phenotype.
Notably,
through
identified
miR-27a-3p
highly
expressed
miRNA
group,
significantly
influences
induction
And
then,
has
ability
transport
PPARγ/NFκB/PI3K/AKT
pathway,
thereby
influencing
We
experiments
rat
carrying
actually
exacerbated
degradation
IVD.In
conclusion,
our
findings
highlight
provide
basis
for
further
investigation
into
mechanism
potential
exosome-based
therapy.