Knowledge Mapping of Exosomes in Autoimmune Diseases: A Bibliometric Analysis (2002–2021)

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 22, 2022

Background Autoimmune diseases (AIDs) are a class of chronic disabling characterized by inflammation and damage to muscles, joints, bones, internal organs. Recent studies have shown that much progress has been made in the research exosomes AIDs. However, there is no bibliometric analysis this field. This study aims provide comprehensive overview knowledge structure hotspots AIDs through bibliometrics. Method Publications related from 2002 2021 were searched on web science core collection (WoSCC) database. VOSviewers, CiteSpace R package “bibliometrix” used conduct analysis. Results 312 articles 48 countries led China United States included. The number publications increasing year year. Central South University, Sun Yat Sen Tianjin Medical University Pennsylvania main institutions. Frontiers immunology most popular journal field, Journal Immunology co-cited journal. These come 473 authors among which Ilias Alevizos, Qianjin Lu, Wei Wei, Jim Xiang Ming Zhao had published papers Clotilde Théry was often. Studying mechanism endogenous occurrence development therapeutic strategy exogenous topics “Mesenchymal stem cells”, “microRNA”, “biomarkers”, “immunomodulation”, “therapy” primary keywords emerging hotspots. Conclusion first comprehensively summarizes trends developments information identifies recent frontiers hot directions, will reference for scholars studying exosomes.

Язык: Английский

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Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Periodontology 2000, Год журнала: 2024, Номер 94(1), С. 257 - 414

Опубликована: Фев. 1, 2024

Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with ability to communicate other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due their be utilized as therapeutic options for a wide array diseases/conditions. Over 5000 publications currently being published yearly on this topic, number is only expected dramatically increase novel strategies continue developed. Today exosomes have been applied numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), procedures (antiaging, bone regeneration, cartilage/joint osteoarthritis, cutaneous wounds, dental dermatology/skin erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord vascular regeneration), cancer therapy (breast, colorectal, gastric osteosarcomas), immune function (allergy, autoimmune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review first its kind aimed at summarizing extensive potential broad range disorders.

Язык: Английский

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Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(12), С. 6480 - 6480

Опубликована: Июнь 9, 2022

Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication through EV-encapsulated informative content, including proteins, lipids, and nucleic acids. Mesenchymal stem cells (MSCs) pluripotent with self-renewal ability derived from bone marrow, fat, umbilical cord, menstruation blood, pulp, etc., which they use to induce tissue regeneration by their direct recruitment into injured tissues, the heart, liver, lung, kidney, or secreting factors, such as vascular endothelial growth factor insulin-like factor. Recently, MSC-derived EVs have been shown regenerative effects against various diseases, partially due post-transcriptional regulation of target genes miRNAs. Furthermore, garnered attention novel drug delivery systems, because can specially encapsulate molecules. In this review, we summarize molecular mechanisms EVs.

Язык: Английский

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Understanding molecular characteristics of extracellular vesicles derived from different types of mesenchymal stem cells for therapeutic translation

Extracellular Vesicle, Год журнала: 2024, Номер 3, С. 100034 - 100034

Опубликована: Март 2, 2024

Mesenchymal stem cells (MSCs) have been studied for decades as candidates cellular therapy, and their secretome, including secreted extracellular vesicles (EVs), has identified to contribute significantly regenerative reparative functions. Emerging evidence suggested that MSC-EVs alone, could be used therapeutics emulate the biological function of MSCs. However, just with MSCs, shown vary in composition, depending on tissue source MSCs well protocols employed culturing obtaining EVs. Therefore, importance careful choice cell sources culture environments is receiving increasing attention. Many factors therapeutic potential MSC-EVs, tissue, isolation technique, conditions. This review illustrates molecular landscape EVs derived from different types MSC along strategies. A thorough analysis publicly available omic datasets was performed advance precision understanding unique source-dependent characteristics. The tissue-specific protein miRNA-driven Reactome ontology reveal distinct patterns top pathways across adipose, bone marrow, umbilical MSC-EVs. Moreover, a meta-analysis assisted by an AI technique analyze published literature, providing insights into translation based tissues.

Язык: Английский

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Mesenchymal Stromal Cell-Based Therapy: A Promising Approach for Autoimmune Diseases

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 21, 2025

Язык: Английский

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Muscle-derived extracellular vesicles improve disuse-induced osteoporosis by rebalancing bone formation and bone resorption

Acta Biomaterialia, Год журнала: 2022, Номер 157, С. 609 - 624

Опубликована: Дек. 13, 2022

Язык: Английский

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Novel potential therapeutic targets of alopecia areata

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Апрель 19, 2023

Alopecia areata (AA) is a non-scarring hair loss disorder caused by autoimmunity. The immune collapse of the follicle, where interferon-gamma (IFN-γ) and CD8+ T cells accumulate, key factor in AA. However, exact functional mechanism remains unclear. Therefore, AA treatment has poor efficacy maintenance high relapse rate after drug withdrawal. Recent studies show that immune-related molecules affect These communicate through autocrine paracrine signals. Various cytokines, chemokines growth factors mediate this crosstalk. In addition, adipose-derived stem (ADSCs), gut microbiota, follicle melanocytes, non-coding RNAs specific regulatory have crucial roles intercellular communication without clear cause, suggesting potential new targets for therapy. This review discusses latest research on possible pathogenesis therapeutic

Язык: Английский

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The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles

International Immunopharmacology, Год журнала: 2023, Номер 122, С. 110531 - 110531

Опубликована: Июль 10, 2023

Язык: Английский

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Advancements in extracellular vesicle targeted therapies for rheumatoid arthritis: insights into cellular origins, current perspectives, and emerging challenges

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 3, 2024

Abstract Rheumatoid arthritis (RA) remains a challenging chronic autoimmune disorder characterized by persistent joint inflammation and damage. While modern regenerative strategies, encompassing cell/stem cell-based therapies, gene therapy, tissue engineering, have advanced repair efforts, definitive cure for RA elusive. Consequently, there is growing interest in developing targeted therapies that directly address the underlying mechanisms driving pathogenesis, such as extracellular vesicles (EVs). These small membrane-bound particles can modulate immune responses within inflammatory microenvironment of damaged cartilage. To launch clinical potential EVs, they be isolated from various cell types through several techniques. EVs carry bioactive molecules anti-inflammatory or pro-regenerative drugs, deliver them to affected joints, affect behavior injured cells, making compelling choice therapy drug delivery patients. However, are still challenges limitations associated with EV-based including absence standardized protocols EV isolation, characterization, delivery. This review provides comprehensive overview cellular sources delves into their therapeutic hurdles must overcome.

Язык: Английский

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Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier

European journal of medical research, Год журнала: 2023, Номер 28(1)

Опубликована: Фев. 20, 2023

Abstract Exosomes are membranous vesicles with a 30 to 150 nm diameter secreted by mesenchymal stem/stromal cells (MSCs) and other cells, such as immune cancer cells. convey proteins, bioactive lipids, genetic components recipient microRNAs (miRNAs). Consequently, they have been implicated in regulating intercellular communication mediators under physiological pathological circumstances. therapy cell-free approach bypasses many concerns regarding the therapeutic application of including undesirable proliferation, heterogeneity, immunogenic effects. Indeed, exosomes become promising strategy treat human diseases, particularly bone- joint-associated musculoskeletal disorders, because their characteristics, potentiated stability circulation, biocompatibility, low immunogenicity, toxicity. In this light, diversity studies indicated that inhibiting inflammation, inducing angiogenesis, provoking osteoblast chondrocyte proliferation migration, negative regulation matrix-degrading enzymes result bone cartilage recovery upon administration MSCs-derived exosomes. Notwithstanding, insufficient quantity isolated exosomes, lack reliable potency test, heterogeneity hurdle clinics. Herein, we will deliver an outline respecting advantages exosomes-based common disorders. Moreover, glimpse underlying mechanism behind MSCs-elicited merits these conditions.

Язык: Английский

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