Cells,
Год журнала:
2022,
Номер
11(21), С. 3346 - 3346
Опубликована: Окт. 24, 2022
Systemic
sclerosis
(SSc)
is
a
systemic
disease
characterized
by
autoimmune
responses,
vasculopathy
and
tissue
fibrosis.
The
pathogenic
mechanisms
involve
wide
range
of
cells
soluble
factors.
complexity
interactions
leads
to
heterogeneous
clinical
features
in
terms
the
extent,
severity,
rate
progression
skin
fibrosis
internal
organ
involvement.
Available
disease-modifying
drugs
have
only
modest
effects
on
halting
may
be
associated
with
significant
side
effects.
Therefore,
cellular
therapies
been
developed
aiming
at
restoration
immunologic
self-tolerance
order
provide
durable
remissions
or
foster
regeneration.
Currently,
SSc
recommended
as
‘standard
indication’
for
autologous
hematopoietic
stem
cell
transplantation
European
Society
Blood
Marrow
Transplantation.
This
review
provides
an
overview
SSc,
from
pre-clinical
models
applications,
opening
towards
more
advanced
therapies,
such
mesenchymal
cells,
regulatory
T
potentially
CAR-T-cell
therapies.
Acta Biomedica Scientifica (East Siberian Biomedical Journal),
Год журнала:
2025,
Номер
10(1), С. 25 - 37
Опубликована: Март 14, 2025
Background
.
Rheumatoid
arthritis
(RA)
is
a
long-term
autoimmune
disease
characterized
by
systemic
immuno-inflammatory
reaction
leading
to
joint
edema,
synovial
hyperplasia,
damage
cartilage
and
bone
tissue.
There
currently
no
effective
treatment
for
this
disease.
The
aim
of
the
literature
review
To
analyze
mechanisms
described
date
that
underlie
effects
mesenchymal
stem
cells
(MSC)
extracellular
vesicles
(EV)
on
pathogenetic
links
rheumatoid
arthritis.
Materials
methods
PubMed
eLibrary
databases
period
2011–2023
were
analyzed
using
keywords:
arthritis,
hematopoietic
cells,
factor,
vesicles,
cell
therapy.
Results
discussion
describes
current
aspects
etiology
pathogenesis
its
potential
biomarkers
known
therapeutic
strategies.
effect
MSC
T
B
lymphocytes,
as
well
other
cellular
participants
in
disease,
has
been
studied
experimental
clinical
studies.
expands
understanding
postnatal
progenitor
their
which,
terms
comparison,
reveals
advantages
disadvantages
each
method.
It
can
be
concluded
EV
are
promising
direction
however,
further
studies
interactions
molecules
affecting
RA
needed.
Additional
based
pathogenetically
ranked
approach
also
necessary,
which
allows
identify
patterns
method
with
subsequent
recommendation
choosing
use
or,
mainly,
secretome
personalized
therapy,
more
detailed
study
dosage,
time
administration
necessary.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 26, 2025
Corneal
alkali
burns
can
cause
persistent
inflammation
and
corneal
neovascularization.
In
this
study,
we
divided
burned
rabbits
into
the
untreated
group,
blank
lens
radiation-treated
umbilical
cord
mesenchymal
stem
cells
(UCMSC)
UCMSC
I.V.
then
measured
inflammation,
neovascularization
injury
repair
via
slit
lamp
microscopy,
captured
anterior
segment
optical
coherence
tomography
(AS-OCT),
performed
hematoxylin-eosin
staining.
Compared
with
those
in
other
experimental
groups,
lenses
significantly
decreased
inflammatory
index
(IF)
scores,
areas
of
blood
vessels
epithelial
injury.
The
expression
interleukin
(IL)-17
corneas
treated
was
lower
than
that
lenses,
exhibited
greater
IL-4
signal
transducer
activator
transcription
1
(STAT1),
while
cluster
differentiation-3G
(CD3G),
a
linker
for
activation
T
(LAT),
IL-6,
IL-1B,
CC
chemokine
receptor
6
(CCR6)
IL-23
opposite
effects
(all
P
<
0.05).
Our
findings
demonstrated
irradiated
UCMSC-coated
high
oxygen-permeable
hydrogel
on
ocular
surface
inhibited
angiogenesis
after
alkaline
burns.
downregulation
Th17
cell
differentiation
might
be
responsible
these
effects.
2022 International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT),
Год журнала:
2022,
Номер
unknown, С. 311 - 314
Опубликована: Окт. 20, 2022
neuroanesthesia
and
critical
care
for
neurosurgical
patients,
the
anesthesiologist
plan
should
have
a
judicious
regimen
of
fluid
management
because
it
will
be
obliging
in
improve
surgical
outcomes.
When
fluids
is
replaced
by
good
regimen,
help
neurosurgeon
to
avoid
brain
edema
formation
intravenous
congestion
whereas
enhancing
patient's
volume
status
maintain
both
adequate
cerebral
perfusion
oxygenation.
We
searched
current
available
literature
RCTs
on
MEDLINE,
EMBASE
Cochrane
Evidence
Based
Medicine
Reviews.
Furthermore,
citation
review
hand
search
new
journals
related
therapy
neuro-surgeries
were
done.
Because
absent
any
specific
evidence
which
concerning
optimal
replacement,
at
least
that
are
demonstrated
harmful
avoided.
Thoughtful
preoperative
appreciatin
pathophysiology
individual
patient
an
effective
maner
suitable
desion
type
amount
fluid.
Every
thing
normal,
this
main
objective
from
during
neurosurgery
can
achieved
maintaining
continuity
each
glocuse
level,
sodium
level
intravascular
within
normality.
Journal of Innate Immunity,
Год журнала:
2023,
Номер
15(1), С. 893 - 910
Опубликована: Янв. 1, 2023
This
study
investigates
whether
bone
marrow
mesenchymal
stem
cell
(BMSC)-derived
extracellular
vesicles
(EVs)
can
affect
rheumatoid
arthritis
(RA)
by
delivering
microRNA
(miR)-378a-5p
to
regulate
the
interferon
regulatory
factor
1/signal
transducer
and
transcription
1
(IRF1/STAT1)
axis.
We
identified
RA-associated
miRNAs
using
GEO
microarray
dataset
GSE121894.
found
most
important
in
RA
synovial
tissues
RT-qPCR.
BMSC-derived
EVs
were
ultracentrifuged
cocultured
with
human
microvascular
endothelial
cells
(HSMECs)
vitro.
Dual-luciferase
RNA
immunoprecipitation
studies
examined
miR-378a-5p’s
specific
binding
IRF1.
also
measured
angiogenesis,
migration,
proliferation
CCK-8,
Transwell,
tube
formation
assays.
Collagen-induced
(CIA)
mice
models
created
inducing
scoring
it.
had
low
miR-378a-5p
expression,
whereas
high
levels.
The
transfer
of
HSMECs
boosted
proliferation,
angiogenesis.
inhibited
MiR-378a-5p-containing
decreased
STAT1
phosphorylation
HSMEC
IRF1
expression.
mimic
promoted
dexmedetomidine
phosphorylation.
In
CIA
mice,
containing
enhanced
vascular
remodeling
histopathology.
Thus,
from
promotes
inactivating
IRF1/STAT1
axis
preventing
RA.
Cells,
Год журнала:
2022,
Номер
11(21), С. 3346 - 3346
Опубликована: Окт. 24, 2022
Systemic
sclerosis
(SSc)
is
a
systemic
disease
characterized
by
autoimmune
responses,
vasculopathy
and
tissue
fibrosis.
The
pathogenic
mechanisms
involve
wide
range
of
cells
soluble
factors.
complexity
interactions
leads
to
heterogeneous
clinical
features
in
terms
the
extent,
severity,
rate
progression
skin
fibrosis
internal
organ
involvement.
Available
disease-modifying
drugs
have
only
modest
effects
on
halting
may
be
associated
with
significant
side
effects.
Therefore,
cellular
therapies
been
developed
aiming
at
restoration
immunologic
self-tolerance
order
provide
durable
remissions
or
foster
regeneration.
Currently,
SSc
recommended
as
‘standard
indication’
for
autologous
hematopoietic
stem
cell
transplantation
European
Society
Blood
Marrow
Transplantation.
This
review
provides
an
overview
SSc,
from
pre-clinical
models
applications,
opening
towards
more
advanced
therapies,
such
mesenchymal
cells,
regulatory
T
potentially
CAR-T-cell
therapies.
