Role of NLRP3 Inflammasome in Post-Spinal-Cord-Injury Anxiety and Depression: Molecular Mechanisms and Therapeutic Implications

ACS Chemical Neuroscience, Год журнала: 2023, Номер 15(1), С. 56 - 70

Опубликована: Дек. 18, 2023

The majority of research on the long-term effects spinal cord injury (SCI) has primarily focused neuropathic pain (NP), psychological issues, and sensorimotor impairments. Among SCI patients, mood disorders, such as anxiety depression, have been extensively studied. It found that chronic stress NP negative consequences reduce quality life for individuals living with SCI. Our review examined both human experimental evidence to explore connection between changes following inflammatory pathways, a specific focus NLRP3 inflammasome signaling. We observed increased proinflammatory factors in blood, well brain tissues models. plays crucial role various diseases by controlling release molecules like interleukin 1β (IL-1β) IL-18. Dysregulation key regions associated processing, prefrontal cortex hippocampus, contributes development disorders In this review, we summarized recent expression regulation components related signaling Finally, discussed potential therapeutic approaches target regulate cytokines way treat

Язык: Английский

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Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Март 27, 2024

Abstract Melatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study. This study was to explore of melatonin inhibiting microglia pyroptosis. In virtro experiments, improved corticosterone-induced ultrastructure microstructure HAPI cells by pyroptosis, thereby increasing cell survival rate. Protein-protein interaction network molecular autodocking predicted that Cathespin B might be target inhibition NLRP3-mediated inhibited expression. Both Cathepsin inhibitor CA-074Me NLRP3 knockout Similarly, agonist Pazopanib-induced activation B/NLRP3 signaling pathway vivo studies, restraint stress (CRS)-induced alleviated pyroptosis in rats. Inhibition CRS-induced behaviors addition, These results demonstrated could alleviate pathway, improving reveals prevention treatment stress-related encephalopathy.

Язык: Английский

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Antidepressant effects of Parishin C in chronic social defeat stress-induced depressive mice

Journal of Ethnopharmacology, Год журнала: 2024, Номер 325, С. 117891 - 117891

Опубликована: Фев. 7, 2024

Язык: Английский

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Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 260, С. 115750 - 115750

Опубликована: Авг. 23, 2023

Язык: Английский

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Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 27, 2024

The high comorbidity of major depressive disorder (MDD) with other diseases has been well-documented. However, the pairwise causal connections for MDD comorbid networks are poorly characterized. We performed Phenome-wide Mendelian randomization (MR) analyses to explore bidirectional associations between (N = 807,553) and 877 common from FinnGen datasets 377,277). inverse variance weighting method was primary technique, methods (weighted median MR-Egger) were used sensitivity analyses. Our MR showed that genetic liability is causally associated risks 324 disease phenotypes (average b: 0.339), including 46 psychiatric behavioral disorders 0.618), 18 neurological 0.348), 44 respiratory 0.345), 40 digestive 0.281), circulatory 0.237), 37 genitourinary 0.271), 66 musculoskeletal connective 0.326), 22 endocrine 0.302), others. In a reverse analysis, total 51 components predisposing various risk 0.086), 5 infectious 0.056), 11 0.106), 14 oncological 0.108), 0.114). Bidirectional identified 15 diseases. For most analyses, little evidence heterogeneity pleiotropy detected. findings confirmed extensive significant role predisposition in contributing human phenotypes, which more pronounced than those seen analysis influences on MDD.

Язык: Английский

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Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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Trends in research on novel antidepressant treatments

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 27, 2025

Mood disorders, such as major depressive disorder and bipolar disorder, are among the most common mental illnesses a leading cause of disability worldwide. Key symptoms these conditions include depressed mood or anhedonia, sleep psychomotor disturbances, changes in appetite weight, fatigue loss energy. Prolonged cognitive disturbances further impair ability to think concentrate often accompanied by persistent feelings worthlessness excessive guilt. Collectively, underscore depression serious, long-term global health issue. In addition, clinical studies indicate growing number patients experiencing difficulties responding treatment, even long term. This phenomenon poses significant challenges for healthcare professionals, families, alike. As result, there is an urgent need therapies that both rapid-acting safe. review aims summarize prevailing trends research on novel antidepressants, emphasizing their diversity multi-directional mechanisms action. The development drugs increasingly focused achieving high efficacy, particularly treatment-resistant depression. Such advances offer potential rapid therapeutic effects without prolonged tedious administration older generation antidepressants. Findings from using animal models continue play crucial role predicting designing new strategies. These remain indispensable understanding physiological newly developed compounds, thereby guiding creation innovative treatments.

Язык: Английский

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A brain-targeted and ROS-responsive natural polysaccharide nanogel for enhancing antidepressant therapy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160719 - 160719

Опубликована: Фев. 1, 2025

Язык: Английский

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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

Neural Regeneration Research, Год журнала: 2023, Номер 19(9), С. 1890 - 1898

Опубликована: Дек. 14, 2023

Previous studies have demonstrated a bidirectional relationship between inflammation and depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat, NLR family pyrin domain-containing 3 (NLRP3) inflammasomes is closely related to pathogenesis various neurological diseases. In patients with major depressive disorder, NLRP3 inflammasome levels are significantly elevated. Understanding role that inflammasome-mediated neuroinflammation plays in depression may be beneficial for future therapeutic strategies. this review, we aimed elucidate mechanisms lead activation as well provide insight into strategies target inflammasome. Moreover, outlined inflammasome, including inflammatory pathway inhibitors, natural compounds, other compounds been shown effective treating Additionally, summarized application inhibitors clinical trials Currently, there scarcity dedicated investigating applications treatment. The modulation microglia holds promise management Further investigations necessary ascertain efficacy safety these approaches potential novel antidepressant treatments.

Язык: Английский

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Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

Frontiers in Aging, Год журнала: 2023, Номер 4

Опубликована: Июнь 1, 2023

In the last decades, important progress has been achieved in understanding of neurotrophic effects intermittent fasting (IF), calorie restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity adult neurogenesis (NSPAN) are essential examples these effects. The importance this respect metabolic switch from glucose to ketone bodies as cellular fuel highlighted. More recently, mimetics (CRMs; resveratrol other polyphenols particular) have investigated thoroughly relation NSPAN. narrative review sections manuscript, recent findings on functions synthesized most molecules involved presented. researched signaling pathways (PI3K, Akt, mTOR, AMPK, GSK3β, ULK, MAPK, PGC-1α, NF-κB, sirtuins, Notch, Sonic hedgehog Wnt) processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart then briefly This provides an accessible entry point literature. annotated bibliography section contribution, brief summaries provided about 30 literature reviews relating interest IF, CR, CRMs Most selected address perspective healthier aging (sometimes discussing epigenetic factors) reduction risk for neurodegenerative diseases (Alzheimer’s disease, Huntington’s Parkinson’s disease) depression improvement cognitive function.

Язык: Английский

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