BioNanoScience, Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117327 - 117327
Опубликована: Авг. 30, 2024
Breast cancer (BC) is one of the most frequently diagnosed cancers in women. Chemotherapy continues to be treatment choice for clinically combating it. Nevertheless, chemotherapy process hindered by multidrug resistance, thereby impacting effectiveness treatment. Multidrug resistance (MDR) refers phenomenon which malignant tumour cells develop anticancer drugs after single exposure. It can occur with a broad range chemotherapeutic distinct chemical structures and mechanisms action, it major causes failure disease relapse. Research has long been focused on overcoming MDR using multiple drug combinations, but this approach often associated serious side effects. Therefore, there pressing need in-depth research into MDR, as well development new reverse improve efficacy breast chemotherapy. This article reviews explores application nano-drug delivery system (NDDS) overcome cancer. The aim offer valuable reference further endeavours.
Язык: Английский
Процитировано
12
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Herein, fluorescent calcium carbonate nanoclusters encapsulated with methotrexate (Mtx) and surface functionalized chitosan (25 nm) (@Calmat) have been developed for the imaging treatment of triple-negative breast cancer (TNBC). These biocompatible, pH-sensitive nanoparticles demonstrate significant potential targeted therapy diagnostic applications. The efficacy (NPs) was evaluated in MDA-MB-231 TNBC cell lines. enhanced permeability retention effect facilitated accumulation NPs, tumor-bearing rats, as confirmed by vivo fluorescence imaging. Treatment @Calmat resulted a marked reduction pro-inflammatory cytokines, levels IL-6 (1225 ± 67 pg/mL), IL-1β (379 69 TNF-α (14.1 2 contrast to diseased control group (IL-6: 2223 99; IL-1β: 1632 90; TNF-α: 40 3 pg/mL). A similar trend observed liver kidney function biomarkers. Mechanistic studies revealed that activates Bax/Bcl-2 signaling pathway, leading cycle arrest G1 phase subsequent late-phase apoptosis. As result, tumor inhibition rate reached 88%, 80% treated rats surviving beyond 100 days. findings highlight strong dual-function theranostic agent management TNBC.
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 88, С. 104969 - 104969
Опубликована: Сен. 18, 2023
Язык: Английский
Процитировано
10
Applied Sciences, Год журнала: 2024, Номер 14(5), С. 1809 - 1809
Опубликована: Фев. 22, 2024
Breast cancer (BC) ranks among the most diagnosed solid tumors worldwide. For decades, significant research efforts have been dedicated to finding selective treatments for these tumors. Currently, primary treatment method BC involves surgery, with subsequent utilization of radiotherapy and chemotherapy. However, often fall short effectively treating due their side effects harm healthy tissues. Today, a range nanoparticles are being developed target cells without affecting surrounding This in-depth review, based on studies, seeks shed light specially designed potential in treatment. Typically, therapeutic drugs or naturally occurring bioactive compounds incorporated into precisely crafted nanoparticles. enhances solubility, longevity bloodstream, distribution body while also minimizing immune reactions. Nanoparticles address shortcomings standalone therapeutics traverse various biological obstacles spanning systemic, microenvironmental, cellular that differ patients diseases. We prioritize breakthroughs nanoparticle design surpass diverse delivery believe smart engineering not only effectiveness general but allows customized solutions specific needs, ultimately leading better outcomes patients.
Язык: Английский
Процитировано
4
Langmuir, Год журнала: 2024, Номер 40(29), С. 14811 - 14822
Опубликована: Июль 9, 2024
Cancer is a major public health problem worldwide, and it the second leading cause of death humans in world. The present study has been directed toward preparation methotrexate-loaded surface-modified solid lipid nanoparticles (SLNs) for potential use as chemotherapeutic formulation cancer therapy. A (C
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144116 - 144116
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(11), С. 13557 - 13567
Опубликована: Май 20, 2024
Nanodrug delivery system (NDDS) has been widely used in tumor diagnosis, chemotherapy, and image-guided surgery. In this work, hollow manganese dioxide nanoparticles (H-MnO2 NPs) were prepared by the template method, followed loading with Methotrexate (MTX), coating dopamine (PDA), coupling fluorescent dye Cy5.5. Finally, NDDC (MnO2/[email protected] NPs, MMPC NPs), capable of dual-mode imaging was successfully synthesized. NPs can realize high-efficiency MTX continuous release pH response vitro. The loaded showed higher cytotoxicity than free MTX. A confocal laser scanning microscope high-level uptake 8305C cells. Both near-infrared fluorescence magnetic resonance (MR) demonstrated a notable long-term accumulation retention model mouse tumors. Therapeutic experiments vivo that MCPC excellent therapeutic effects biological safety. These results suggest MnO2-based nanodrug systems delivering for therapy enhancing MR contrast are good candidates cancer diagnosis treatment.
Язык: Английский
Процитировано
2
AAPS PharmSciTech, Год журнала: 2024, Номер 25(6)
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
2
BioNanoScience, Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
1