Esculin inhibits hepatic stellate cell activation and CCl4-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway

Phytomedicine, Год журнала: 2024, Номер 128, С. 155465 - 155465

Опубликована: Фев. 17, 2024

Язык: Английский

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Pharmacological activities of esculin and esculetin: A review

Medicine, Год журнала: 2023, Номер 102(40), С. e35306 - e35306

Опубликована: Окт. 6, 2023

Esculin and esculetin are 2 widely studied coumarin components of Cortex Fraxini , which is a well-known herbal medicine with 2000-year history. In vivo in vitro studies have demonstrated that both variety pharmacological activities, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, antidiabetic, immunomodulatory, anti-atherosclerotic, so on. Their underlying mechanisms action biological activities include scavenging free radicals, modulating the nuclear factor erythroid 2-related pathway, regulating cell cycle, inhibiting tumor proliferation migration, promoting mitochondrial pathway apoptosis, NF-κB MAPK signaling pathways, CD4 + T cells differentiation associated cytokine release, vascular smooth muscle cells, etc. This review aims to provide comprehensive information on esculin esculetin, noteworthy importance exploring therapeutic potential compounds.

Язык: Английский

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Clinical observation of esculin and digitalisglycosides eye drops with 0.3% sodium hyaluronate eye drops for dry eye disease: a randomized controlled trial

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 17, 2025

Язык: Английский

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Kirenol ameliorates endotoxin-induced acute lung injury by inhibiting the ERK and JNK phosphorylation–mediated NFκB pathway in mice

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

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Targeting neutrophil dysfunction in acute lung injury: insights from active components of Chinese medicine

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156664 - 156664

Опубликована: Март 1, 2025

Язык: Английский

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Esculin targets TLR4 to protect against LPS-induced septic cardiomyopathy

International Immunopharmacology, Год журнала: 2024, Номер 131, С. 111897 - 111897

Опубликована: Март 20, 2024

Язык: Английский

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3-methyladenine ameliorates acute lung injury by inhibiting oxidative damage and apoptosis

Heliyon, Год журнала: 2024, Номер 10(13), С. e33996 - e33996

Опубликована: Июль 1, 2024

Acute lung injury (ALI) is a condition characterized by inflammation and oxidative damage. 3-methyladenine (3-MA) has great potential for regulating apoptosis, but its regulatory role in ALI unknown.

Язык: Английский

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Cow’s Milk Protein May Induce Allergy and Inflammation in Intestinal Epithelial Cells Through Regulating HOTAIR Expression and NF‐κB Signaling Pathway

Journal of Food Biochemistry, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Background: Cow’s milk protein allergy (CMPA) is associated with activation of proinflammatory signaling pathways and overexpression inflammatory mediators. Long noncoding RNA (LncRNA) HOX transcript antisense intergenic (HOTAIR) a LncRNA, which involved in the occurrence development many biological processes diseases. HOTAIR can prevent necrotizing enterocolitis. This study aims to explore effect on NCM‐460 cells its mechanism action HOTAIR. Methods: were induced by cow’s establish vitro cell models. CCK‐8 EdU staining used for evaluating effects viability proliferation. ELISA was comparing levels cytokines. TUNEL conducted apoptosis. Expression detected RT‐qPCR. The expression NF‐κB pathway–related molecules explored evaluate improving ALI. Results: decreased also Moreover, it induce antiproliferative proapoptotic cells, LncRNA partially reverse protein. In addition, reversed signaling. Conclusions: may inflammation intestinal epithelial through regulating pathways.

Язык: Английский

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Esculin alleviates lipopolysaccharide (LPS)–induced pneumonia by regulating the USP7/MAPK14 axis

Journal of Applied Toxicology, Год журнала: 2024, Номер 44(12), С. 1949 - 1961

Опубликована: Авг. 14, 2024

Abstract Pneumonia is a serious and life‐threatening lung inflammation with high morbidity mortality. Accumulating evidence has suggested that esculin, derivative of coumarin, possesses potent anti‐inflammatory effects. This study designed to explore the pharma role underlying mechanism esculin against lipopolysaccharides (LPS)‐induced pneumonia. TC‐1 cells were stimulated by LPS mimic inflammatory injury model in vitro . Cell viability, proliferation, apoptosis determined using MTT assay, 5‐ethynyl‐2′‐deoxyuridine flow cytometry. Interleukin‐1β tumor necrosis factor α levels analyzed an enzyme‐linked immunosorbent assay. Reactive oxygen species superoxide dismutase examined special assay kits. Macrophage polarization was detected Mitogen‐activated protein kinase 14 (MAPK14) level real‐time quantitative polymerase chain reaction. MAPK14 ubiquitin‐specific protease 7 (USP7) western blot After Ubibrowser database prediction, interaction between USP7 verified Co‐immunoprecipitation The biological LPS‐challenged ALI mice vivo Here, we found significantly relieved LPS‐induced cell proliferation inhibition, apoptosis, response, oxidative stress, M1‐type macrophage promotion. expressions enhanced LPS‐treated cells, which partly abolished treatment. Overexpressing attenuated repression on LPS‐triggered injury. At molecular level, interacted maintained its stability removing ubiquitin. Moreover, repressed progression pneumonia regulating MAPK14. Taken together, exposure could mitigate targeting USP7/MAPK14 axis, providing better understanding therapeutics for

Язык: Английский

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Musa paradisiaca L. Inflorescence Abrogates Neutrophil Activation by Downregulating TLR4/NF-KB Signaling Pathway in LPS-Induced Acute Lung Injury Model

Pharmaceuticals, Год журнала: 2024, Номер 18(1), С. 8 - 8

Опубликована: Дек. 24, 2024

Background/Objectives: Acute lung injury (ALI) is an inflammatory disorder affecting patients in intensive care with high mortality. No specific pharmacological treatment available. Musa paradisiaca L. (banana) a cosmopolitan plant, and homemade syrup from its inflorescence used many countries to treat pulmonary inflammation. Therefore, this study analyzed the hydroalcoholic extract (HEM) of on ALI experimental model. Methods: Swiss mice were challenged lipopolysaccharide treated HEM after 1, 24, 48 h (five animals/group, three times). Results: The HEM-treated presented decrease neutrophil migration bronchoalveolar lavage fluid (BALF), alveolar region, blood, correlating downregulation CD18 expression. also reduced protein concentration BALF, caused edema formation, impaired NF-κB activation via inhibition TLR4 signaling pathway, decreased IL-1β, TNF-α production, free DNA release, myeloperoxidase (MPO) activity. However, induced increased IL-10 BALF. Conclusions: HEM’s anti-inflammatory immunomodulatory activities are by deactivating neutrophils decreasing receptor, MPO activity inducing production. Thus, supports use banana folk medicine suggests rational develop phytomedicine

Язык: Английский

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