Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
ABSTRACT
Osteoporosis
(OP)
is
a
globally
prevalent
bone
disease
characterized
by
reduced
mass
and
heightened
fracture
risk,
posing
significant
health
economic
challenge
to
aging
societies
worldwide.
Osteoimmunology—an
emerging
field
of
study—investigates
the
intricate
relationship
between
skeletal
immune
systems,
providing
insights
into
system's
impact
on
progression.
Recent
research
has
demonstrated
essential
roles
played
various
cells
(T
cells,
B
macrophages,
dendritic
mast
granulocytes,
innate
lymphoid
cells)
in
regulating
metabolism,
homeostasis,
formation,
remodeling
through
interactions
with
osteoclasts
(OC)
osteoblasts
(OB).
These
findings
underscore
that
osteoimmunology
provides
an
theoretical
framework
for
understanding
pathogenesis
disorders,
including
OP.
Traditional
Chinese
medicine
(TCM)
its
active
ingredients
have
clinical
value
OP
treatment.
Unfortunately,
despite
their
striking
multieffect
pathways
pharmacological
field,
current
not
yet
summarized
them
comprehensive
detailed
manner
respect
interventional
diseases,
especially
Consequently,
this
review
addresses
recent
studies
mechanisms
which
communication
molecules
contribute
development.
Additionally,
it
explores
potential
therapeutic
benefits
TCM
components
treating
from
perspective
osteoimmunology.
The
objective
provide
enhances
immune‐related
diseases
facilitate
development
novel
strategies.
Molecules,
Год журнала:
2024,
Номер
29(2), С. 540 - 540
Опубликована: Янв. 22, 2024
Sinomenine,
an
isoquinoline
alkaloid
extracted
from
the
roots
and
stems
of
Sinomenium
acutum,
has
been
extensively
studied
for
its
derivatives
as
bioactive
agents.
This
review
concentrates
on
research
advancements
in
biological
activities
action
mechanisms
sinomenine-related
compounds
until
November
2023.
The
findings
indicate
a
broad
spectrum
pharmacological
effects,
including
antitumor,
anti-inflammation,
neuroprotection,
immunosuppressive
properties.
These
are
notably
effective
against
breast,
lung,
liver,
prostate
cancers,
exhibiting
IC50
values
approximately
121.4
nM
PC-3
DU-145
cells,
primarily
through
PI3K/Akt/mTOR,
NF-κB,
MAPK,
JAK/STAT
signaling
pathways.
Additionally,
they
manifest
anti-inflammatory
analgesic
effects
predominantly
via
Nrf2
Utilized
treating
rheumatic
arthritis,
these
alkaloids
also
play
significant
role
cardiovascular
cerebrovascular
protection,
well
organ
protection
Nrf2,
PI3K/Akt/mTOR
concludes
with
perspectives
insights
this
topic,
highlighting
potential
clinical
applications
development
medications
derived
natural
products.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 1, 2024
The
characteristic
features
of
the
rheumatoid
arthritis
(RA)
microenvironment
are
synovial
inflammation
and
hyperplasia.
Therefore,
there
is
a
growing
interest
in
developing
suitable
therapeutic
strategy
for
RA
that
targets
macrophages
fibroblast-like
synoviocytes
(FLSs).
In
this
study,
we
used
graphene
oxide
quantum
dots
(GOQDs)
loading
anti-arthritic
sinomenine
hydrochloride
(SIN).
By
combining
with
hyaluronic
acid
(HA)-inserted
hybrid
membrane
(RFM),
successfully
constructed
new
nanodrug
system
named
HA@RFM@GP@SIN
NPs
target
therapy
inflammatory
articular
lesions.
Mechanistic
studies
showed
nanomedicine
was
effective
against
by
facilitating
transition
M1
to
M2
inhibiting
abnormal
proliferation
FLSs
vitro.
vivo
potential
investigation
demonstrated
its
effects
on
macrophage
polarization
hyperplasia,
ultimately
preventing
cartilage
destruction
bone
erosion
preclinical
models
adjuvant-induced
collagen-induced
rats.
Metabolomics
indicated
were
mainly
associated
regulation
steroid
hormone
biosynthesis,
ovarian
steroidogenesis,
tryptophan
metabolism,
tyrosine
metabolism.
More
notably,
transcriptomic
analyses
revealed
suppressed
cell
cycle
pathway
while
inducing
apoptosis
pathway.
Furthermore,
protein
validation
disrupted
excessive
growth
RAFLS
interfering
PI3K/Akt/SGK/FoxO
signaling
cascade,
resulting
decline
cyclin
B1
expression
arrest
G2
phase.
Additionally,
considering
favorable
biocompatibility
biosafety,
these
multifunctional
nanoparticles
offer
promising
approach
patients
RA.
Heliyon,
Год журнала:
2023,
Номер
10(1), С. e23581 - e23581
Опубликована: Дек. 11, 2023
Sinomenine
(SN)
is
a
well-documented
unique
plant
alkaloid
extracted
from
many
herbal
medicines.
The
present
study
evaluates
the
wound
healing
potentials
of
SN
on
dorsal
neck
injury
in
rats.
A
uniform
cut
was
created
Sprague
Dawley
rats
(24)
which
were
arbitrarily
aligned
into
4
groups
receiving
two
daily
topical
treatments
for
14
days
as
follows:
A,
had
gum
acacia;
B,
addressed
with
intrasite
gel;
C
and
D,
30
60
mg/ml
SN,
respectively.
acute
toxicity
trial
revealed
absence
any
toxic
signs
after
weeks
ingestion
300
mg/kg
SN.
SN-treated
showed
smaller
areas
higher
closure
percentages
compared
to
vehicle
5,
10,
15
skin
excision.
Histological
evaluation
recovered
tissues
increased
collagen
deposition,
fibroblast
content,
decreased
inflammatory
cells
granulated
SN-addressed
rats,
statistically
different
that
acacia-treated
treatment
caused
positive
augmentation
Transforming
Growth
Factor
Beta
1
(angiogenetic
factor)
tissues,
denoting
conversion
rate
myofibroblast
(angiogenesis)
results
faster
action.
Increased
antioxidant
enzymes
(SOD
CAT),
well
MDA
contents
suggest
aid
recovery.
Wound
tissue
homogenates
hydroxyproline
amino
acid
(collagen
content)
values
than
suppressed
production
pro-inflammatory
cytokines
anti-inflammatory
serum
wounded
outcomes
viable
pharmaceutical
agent
evidenced
by
its
modulation
antioxidant,
immunohistochemically
proteins,
hydroxyproline,
cytokines.
World Journal of Stem Cells,
Год журнала:
2024,
Номер
16(5), С. 486 - 498
Опубликована: Май 23, 2024
A
decreased
autophagic
capacity
of
bone
marrow
mesenchymal
stromal
cells
(BMSCs)
has
been
suggested
to
be
an
important
cause
osteogenic
differentiation.
pharmacological
increase
in
autophagy
BMSCs
is
a
potential
therapeutic
option
osteoblast
viability
and
ameliorate
osteoporosis.
