Prospective Coronavirus Liver Effects: Available Knowledge DOI Creative Commons

Mandal Avishek

Annals of Clinical Gastroenterology and Hepatology, Год журнала: 2023, Номер 7(1), С. 001 - 010

Опубликована: Авг. 18, 2023

The global pandemic COVID-19, caused by SARS-CoV-2, affected millions of people. COVID-19 is known for its respiratory symptoms, but new research reveals it may also affect other organ systems, including the liver. This abstract reviews and liver function. virus enters host cells through liver-expressed angiotensin-converting enzyme 2 (ACE2) receptors. Thus, viral infection replication target Virus-induced inflammation cytokine production harm ALT AST elevations are most prevalent abnormalities in patients. Liver function test frequently indicate serious illness poor clinical outcomes. worsen pre-existing diseases such as NAFLD chronic hepatitis. Drug-induced damage (DILI) from therapies antivirals corticosteroids complicates complications care. Recent investigations have shown that cause long-term damage. In conclusion, infection, immune-mediated damage, treatment problems severely compromise Optimizing patient discovering targeted medicines requires understanding COVID-19's role. To reduce effects on function, further study required to understand mechanisms effects.

Язык: Английский

Study on SARS-CoV-2 infection in middle-aged and elderly population infected with hepatitis virus: a cohort study in a rural area of northeast China DOI Creative Commons
Yuchen Pan, Zhifang Jia, Xinyi Yu

и другие.

PeerJ, Год журнала: 2025, Номер 13, С. e19021 - e19021

Опубликована: Фев. 21, 2025

Background To investigate the symptoms, level of antibody, progression liver disease after SARS-CoV-2 infection in middle-aged and elderly population infected with hepatitis virus. Methods The study was based on a cohort high-risk cancer participants recruited April 2023. Blood sample were collected information obtained through questionnaires. Data reinfection by follow-up until July 31, SARS-CoV-2-specific neutralizing antibody IgG measured. Results A total 599 virus included mean age 61.3 ± 7.4 years. rate 94.7%. Among infected, 132 asymptomatic, 435 symptomatic, no severe cases occurred. Four months infection, difference function aMAP score between uninfected. had higher seropositivity rates both antibodies than uninfected (neutralizing antibody: uninfected: 93.7%, infected: 99.6%; IgG: 59.4%, 98.9%). levels symptomatic those asymptomatic 0.75 AU/mL, asymptomatic: 15.46 symptomatic: 24.76 AU/mL; 15.10 263.84 291.83 AU/mL). By 2023, incidence 17.5%. Conclusions Although high, Omicron may not aggravate hepatitis. showed high positivity IgG. Monitoring mutations targeted prevention care strategies is crucial for vulnerable populations.

Язык: Английский

Процитировано

0
Impact of Remdesivir Treatment on Factor VIII Gene Expression and Hematological Parameters in COVID-19 Patients DOI

Ghazal Kakavand,

Somayeh Arabzadeh, Sohameh Mohebbi

и другие.

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107536 - 107536

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Arbidol attenuates liver fibrosis and activation of hepatic stellate cells by blocking TGF-β1 signaling DOI

Younan Ren,

Ying Chen,

Emily H. Tang

и другие.

European Journal of Pharmacology, Год журнала: 2024, Номер 967, С. 176367 - 176367

Опубликована: Фев. 6, 2024

Язык: Английский

Процитировано

3
Telemedicine as an Option for Monitoring Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Patients Facing the COVID-19 Pandemic: A Systematic Review and Meta-Analysis DOI Open Access
Femmy Nurul Akbar,

Safira Rosiana Choirida,

Ahmad Zaqi Muttaqin

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(3), С. 281 - 281

Опубликована: Март 2, 2024

Healthcare visits were reduced during the COVID-19 pandemic, causing disturbances in sustainable MAFLD monitoring. Telemedicine acts to maintain connectivity between patients and healthcare professionals. This review aimed assess role of telemedicine monitoring pandemic. Databases searched included l PubMed Central ScienceDirect from 2020 2023. Assessment with The Cochrane Risk Bias for randomized controlled trials (RCTs) Newcastle-Ottawa scale non-RCTs systematic reviews. Meta-analyses employing a random-effect model performed determine pooled mean difference (MD) p-value. results showed three RCT two non-RCT (n = 239) 56.9% males age 51.3 years. median intervention duration was 5.5 months. parameters assessed body weight (BW), mass index (BMI), waist circumference, liver function (AST/ALT), lipid profile, HbA1c, others. Meta-analysis revealed that had significant effect on improving outcomes BW (MD −2.81: 95% CI, −4.11, −1.51, p < 0.0001) BMI −1.01: −1.47, −0.55, compared standard care, while AST/ALT levels not significantly reduced. Some biochemical markers decreased based In conclusion, using mobile-based applications could be an option lifestyle modification facing

Язык: Английский

Процитировано

2
Drug Repurposing for COVID-19 by Constructing a Comorbidity Network with Central Nervous System Disorders DOI Open Access
Jing Qian, Bin Yang, Shuo Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8917 - 8917

Опубликована: Авг. 16, 2024

In the post-COVID-19 era, treatment options for potential SARS-CoV-2 outbreaks remain limited. An increased incidence of central nervous system (CNS) disorders has been observed in long-term COVID-19 patients. Understanding shared molecular mechanisms between these conditions may provide new insights developing effective therapies. This study developed an integrative drug-repurposing framework COVID-19, leveraging comorbidity data with CNS disorders, network-based modular analysis, and dynamic perturbation analysis to identify drug targets candidates against SARS-CoV-2. We constructed a network based on literature collection, including COVID-19-related proteins genes associated Alzheimer’s disease, Parkinson’s multiple sclerosis, autism spectrum disorder. Functional module detection annotation identified primarily involved protein synthesis as key target module, utilizing connectivity map data. Through construction weighted drug–target ubiquitin–carboxy-terminal hydrolase L1 emerged target. Molecular dynamics simulations suggested pregnenolone BRD-K87426499 two COVID-19. introduces dynamic-perturbation-network-based approach by incorporating disorders.

Язык: Английский

Процитировано

1
Effects of COVID-19 on the Liver and Mortality in Patients with SARS-CoV-2 Pneumonia Caused by Delta and Non-Delta Variants: An Analysis in a Single Centre DOI Creative Commons
Monica Muntean, Violeta Briciu, Mihaela Lupșe

и другие.

Pharmaceuticals, Год журнала: 2023, Номер 17(1), С. 3 - 3

Опубликована: Дек. 19, 2023

The aim of this study was to ascertain patient characteristics, outcomes, and liver injuries in patients infected with different SARS-CoV-2 variants. Data from consecutive adult severe/critical COVID-19 admitted our hospital during the peak month Delta wave were compared ancestral, Alpha, Omicron waves. dataset 551 hospitalized similar Delta/non-Delta At admission discharge, median aminotransferase levels normal or slightly increased. During (172 vs. 379 non-Delta patients), more died (OR 1.69, 95%CI 1.09–2.56) had injury at discharge (alanine aminotransferase, ALT ≥ 2 ULN) 1.97, 1.08–3.54). In-hospital mortality associated age, lung injury, intensive care unit admission, number cardiovascular comorbidities, diabetes, chronic kidney disease, all inflammatory biomarkers. Serious (ALT 5 × significantly in-hospital = 7.9, 2–28.9). drug-induced (DILI) found treated remdesivir, ULN 2.62, 1.22–5.75). Treatment dexamethasone, immunomodulators showed improved survival, OR 0.50 (95%CI 0.33–0.77). Regardless variant treatment options, less than 2% displayed serious which not be a death predictor multivariable analysis.

Язык: Английский

Процитировано

3
Omicron variant raises global concerns: Increased hospitalization and India's vaccination advantage DOI Creative Commons
Azhagu Madhavan Sivalingam, Arjun Pandian

Intelligent Pharmacy, Год журнала: 2023, Номер 1(4), С. 201 - 206

Опубликована: Сен. 2, 2023

The newly identified COVID-19 variant, B.1.1.529, initially detected in South Africa, was officially designated as the "Omicron" variant by World Health Organization on November 26, 2021. This has raised concerns globally. From January 17 to 2021, Public Ontario (PHO) Library Services conducted extensive searches of published literature and preprints using MEDLINE database. A total six articles one ongoing clinical trial were identified. Data from 15 unpublished reports, including interim findings, collected. WHO, ICMR, daily updates web page, internet sources, news, hospitalization or death data analyzed assess risk associated with Omicron compared non-hospitalized patients. suggested a potential 50% increase among patients previous variants. Considering emergence it is important note that India an advantage due its immunization program, which annually vaccinates approximately 2.7 crorenewborns. However, crucial ensure vaccines meet all validation requirements regulatory frameworks before they are made available public.

Язык: Английский

Процитировано

1
Liver function abnormality on admission predicts long COVID syndrome in digestive system DOI Creative Commons

Huibin Wu,

Yunjie Zhang, Wenqing Tang

и другие.

Heliyon, Год журнала: 2024, Номер 10(19), С. e37664 - e37664

Опубликована: Сен. 12, 2024

Язык: Английский

Процитировано

0
Impact of COVID-19 infection on patients with chronic liver disease in Sohag University Hospital. DOI Open Access

Ali Hussein Mohammed,

Mustafa Z Younis,

Amr Zaghloul

и другие.

Sohag Medical Journal, Год журнала: 2024, Номер 28(2), С. 64 - 72

Опубликована: Март 9, 2024

Background The pandemic of the coronavirus disease 2019 (COVID-19) has significantly impacted global public health and presented diverse clinical symptoms. Liver involvement in COVID-19 is notable, affecting a significant proportion patients. MethodsA retrospective cross-sectional study was conducted at Sohag University Hospital. A comparative analysis between CLD patients with without COVID-19. employed logistic regression receiver operating characteristic (ROC) curve to explore predictors severity patients.Results272 participants were included: 66 control group 206 varying severity. White blood cell count (WBC) notably higher severe cases compared mild ,moderate . Absolute lymphocytic also displayed differences, having values (2.25 ± 0.73) (1.9 0.86), moderate (1.27 0.52), (1.3 0.78). Furthermore, C-reactive protein (CRP) varied significantly, highest levels (92.9 46), followed by (46.7 40.2), (13.49 19.5), (5.6 1.9). Elevated CRP (P = 0.001) sensitivity 98%, D-dimer 0.008) 95.7%, ESR 78.7%, LDH 0.013) 72.3% associated predicted increased severity.ConclusionThis research enhances understanding COVID-19's impact on individuals CLD, highlighting significance CRP, D-dimer, ESR, as

Язык: Английский

Процитировано

0
Prospective Coronavirus Liver Effects: Available Knowledge DOI Creative Commons

Mandal Avishek

Annals of Clinical Gastroenterology and Hepatology, Год журнала: 2023, Номер 7(1), С. 001 - 010

Опубликована: Авг. 18, 2023

The global pandemic COVID-19, caused by SARS-CoV-2, affected millions of people. COVID-19 is known for its respiratory symptoms, but new research reveals it may also affect other organ systems, including the liver. This abstract reviews and liver function. virus enters host cells through liver-expressed angiotensin-converting enzyme 2 (ACE2) receptors. Thus, viral infection replication target Virus-induced inflammation cytokine production harm ALT AST elevations are most prevalent abnormalities in patients. Liver function test frequently indicate serious illness poor clinical outcomes. worsen pre-existing diseases such as NAFLD chronic hepatitis. Drug-induced damage (DILI) from therapies antivirals corticosteroids complicates complications care. Recent investigations have shown that cause long-term damage. In conclusion, infection, immune-mediated damage, treatment problems severely compromise Optimizing patient discovering targeted medicines requires understanding COVID-19's role. To reduce effects on function, further study required to understand mechanisms effects.

Язык: Английский

Процитировано

0