Endogenous opiates and behavior: 2023

Peptides, Год журнала: 2024, Номер 179, С. 171268 - 171268

Опубликована: Июнь 28, 2024

Язык: Английский

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Peripheral mu-opioid receptor activation by dermorphin [D-Arg2, Lys4] (1–4) amide alleviates behavioral and neurobiological aberrations in rat model of chemotherapy-induced neuropathic pain

Neurotherapeutics, Год журнала: 2023, Номер 21(1), С. e00302 - e00302

Опубликована: Дек. 19, 2023

Paclitaxel, a frequently utilized chemotherapeutic agent, often gives rise to severe and distressing sensory neuropathy in patients undergoing chemotherapy. Unfortunately, current therapeutics for chemotherapy-induced neuropathic pain (CINP) demonstrate limited effectiveness are burdened with the potential central side effects such as sedation, respiratory depression, cognitive impairment, addiction, posing substantial clinical challenges. In light of these limitations, present study is designed investigate therapeutic Dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), preferential peripherally acting mu-opioid receptor agonist, rat model CINP. The primary objective was assess analgesic properties DALDA elucidate underlying mechanisms governing its activity. Our findings revealed that treatment significantly ameliorated paclitaxel-induced evoked spontaneous ongoing rats without causing drug addiction other effects. Molecular analyses further unveiled paclitaxel administration resulted increased expression TRP channels, NR2B, voltage-gated sodium channels (VGSCs) neuroinflammatory markers both dorsal root ganglion (DRG) spinal cord (L4-L5 region) rats. downregulated ion (TRPs, VGSCs) NR2B expressions, concomitant inhibition microglial activation, resulting suppression oxido-nitrosative stress cascade. Findings from suggests peripheral receptors may offer target suffering CINP, offering new avenues improved relief while minimizing

Язык: Английский

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Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 6089 - 6100

Опубликована: Янв. 26, 2024

Язык: Английский

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Statins ameliorate oxaliplatin- and paclitaxel-induced peripheral neuropathy via glutathione-S-transferase

Neurochemistry International, Год журнала: 2024, Номер unknown, С. 105863 - 105863

Опубликована: Сен. 1, 2024

Язык: Английский

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Development and validation of clinically Mimicable model of frostbite injury-induced chronic pain

Cellular Signalling, Год журнала: 2024, Номер 115, С. 111028 - 111028

Опубликована: Янв. 2, 2024

Язык: Английский

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Capsaicin nanocrystals burdened topical polymeric gel: An encouraging tactic for alleviation of paclitaxel-induced peripheral neuropathy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125082 - 125082

Опубликована: Дек. 12, 2024

Язык: Английский

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Identification of Key Genes and Pathways in Oxaliplatin-Induced Neuropathic Pain Through Bioinformatic Analysis

Journal of Pain Research, Год журнала: 2024, Номер Volume 17, С. 1639 - 1650

Опубликована: Май 1, 2024

Background: The mechanism of Chemotherapy-induced neuropathic pain (NP) remains obscure. This study was aimed to uncover the key genes as well protein networks that contribute Oxaliplatin-induced NP. Material/Methods: Oxaliplatin frequently results in a type NP is marked by heightened sensitivity mechanical and cold stimuli, which can lead intolerance discontinuation medication. We investigated whether these different etiologies similar pathological outcomes targeting shared genetic targets or signaling pathways. Gene expression data were obtained from Expression Comprehensive Database (GEO) for GSE38038 (representing differential spinal nerve ligation model rats) GSE126773 among rats). Differential gene analysis performed using GEO2R. Results: Protein-protein interaction (PPI) identified 260 co-differentially expressed (co-DEGs). Subsequently, Kyoto Encyclopedia Genes Genomes (KEGG) revealed three pathways involved both models: Kaposi sarcoma-associated herpesvirus (KSHV) infection, Epstein-Barr virus (EBV) AGE-RAGE pathway diabetic complications. Further bioinformatics highlighted eight significantly up-regulated group: Mapk14, Icam1, Cd44, IL6, Cxcr4, Stat1, Casp3 Fgf2. Our suggest immune dysfunction, inflammation-related factors regulating inflammation may also be related Additionally, we analyzed dataset (GSE145222) involving chronic compression DRGs (CCD) control groups. CCD classic studying assessed hub genes' levels. In contrast with groups, difference statistically significant, except Stat1. Conclusion: research contributes elucidating mechanisms underlying occurrence progression have crucial associated this condition. Keywords: pain, oxaliplatin, dorsal horn, bioinformatics, differentially genes,

Язык: Английский

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Biased signalling in analgesic research and development

Current Opinion in Pharmacology, Год журнала: 2024, Номер 76, С. 102465 - 102465

Опубликована: Июнь 1, 2024

Ligand bias offers a novel means to improve the therapeutic profile of drugs. With regard G protein-coupled receptors involved in analgesia, it could be advantageous develop such drugs if analgesic effect is mediated by different cellular signalling pathway than adverse effects associated with drug. Whilst this has been explored over number years for μ receptor, remains unclear whether approach significant benefit treatment pain. Nevertheless, development biased ligands at other CNS does offer some promise future. Here we summarise and discuss recent evidence support this.

Язык: Английский

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Dorsal root ganglion inflammation by oxaliplatin toxicity: DPEP1 as possible target for peripheral neuropathy prevention

BMC Neuroscience, Год журнала: 2024, Номер 25(1)

Опубликована: Сен. 15, 2024

Язык: Английский

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Focal Adhesion Kinase Inhibition Ameliorates Burn Injury-Induced Chronic Pain in Rats

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 26, 2024

Язык: Английский

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