Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 20, 2024
Objective
The
relationship
between
post-traumatic
stress
disorder
(PTSD)
and
autoimmune
thyroid
disease
(AITD)
needs
further
evaluation.
This
study
employs
Mendelian
randomization
(MR)
to
investigate
the
causal
correlations
of
PTSD
with
thyroiditis
(AIT)
Graves’
(GD).
Methods
Datasets
for
PTSD,
AIT,
GD
were
obtained
from
FinnGen.
exposure-outcome
was
assessed
using
inverse
variance
weighted,
MR-Egger,
weighted
median.
Horizontal
pleiotropy
evaluated
through
MR-Egger
intercept,
heterogeneity
examined
Cochran’s
Q
test,
robustness
via
leave-one-out
sensitivity
analysis.
Results
MR
analysis
indicated
no
significant
AIT
(OR
0.920,
95%
CI
0.832
1.017,
p
=
0.103),
but
a
potential
increase
in
risk
associated
1.056,
1.008
1.105,
0.021).
intercept
showed
horizontal
(
>
0.05),
0.05).
Sensitivity
suggested
results
robust.
Conclusions
Evidence
an
association
genetic
liability
increased
provided,
evidence
AIT.
findings
indicate
that
individuals
may
have
likelihood
developing
GD,
underscoring
importance
research
comprehend
intricate
interplay
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Chronic
variable
stress
(CVS)
procedures
are
widely
used
to
model
depression
in
laboratory
rodents.
We
systematically
documented
the
experimental
design
mouse
CVS
studies,
and
of
behavioural
tests
evaluate
effect
CVS.
In
a
subset
we
measured
sizes
tests.
Across
202
82%
unique
procedure.
took
advantage
this
variability
ask
whether
duration
intensity
correlated
with
effects
obtained
five
commonly-used
tests:
sucrose
preference
test
(SPT),
tail
suspension
(TST),
forced
swim
(FST),
open
field
(OFT)
elevated
plus
maze
(EPM).
The
most
evident
impact
procedure
on
were
seen
FST
where
longer-duration
more
diverse
types
stressors
associated
smaller
size.
Next,
between
explore
these
might
measure
similar
or
different
consequences
found
positive
correlation
TST
FST,
OFT
EPM,
but
two
strongest
correlations
EPM
TST,
FST.
studies
deliberately
impose
suffering
over
long
periods,
our
data
raise
scientific
ethical
questions
around
them.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 20, 2024
Objective
The
relationship
between
post-traumatic
stress
disorder
(PTSD)
and
autoimmune
thyroid
disease
(AITD)
needs
further
evaluation.
This
study
employs
Mendelian
randomization
(MR)
to
investigate
the
causal
correlations
of
PTSD
with
thyroiditis
(AIT)
Graves’
(GD).
Methods
Datasets
for
PTSD,
AIT,
GD
were
obtained
from
FinnGen.
exposure-outcome
was
assessed
using
inverse
variance
weighted,
MR-Egger,
weighted
median.
Horizontal
pleiotropy
evaluated
through
MR-Egger
intercept,
heterogeneity
examined
Cochran’s
Q
test,
robustness
via
leave-one-out
sensitivity
analysis.
Results
MR
analysis
indicated
no
significant
AIT
(OR
0.920,
95%
CI
0.832
1.017,
p
=
0.103),
but
a
potential
increase
in
risk
associated
1.056,
1.008
1.105,
0.021).
intercept
showed
horizontal
(
>
0.05),
0.05).
Sensitivity
suggested
results
robust.
Conclusions
Evidence
an
association
genetic
liability
increased
provided,
evidence
AIT.
findings
indicate
that
individuals
may
have
likelihood
developing
GD,
underscoring
importance
research
comprehend
intricate
interplay
disorders.
