International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 84 - 84
Опубликована: Дек. 25, 2024
Canine
distemper
(CD)
is
a
highly
infectious
disease
of
dogs
which
caused
by
canine
virus
(CDV).
Previous
studies
have
demonstrated
that
CDV
infection
can
induce
autophagy
in
cells.
However,
the
mechanism
underlying
CDV-induced
remains
not
fully
understood.
The
non-structural
protein
V
plays
vital
role
viral
replication
and
pathogenicity
host.
In
this
study,
we
investigated
relationship
between
CDV-V
induction
further
explored
its
impact
on
behind
this.
Our
results
showed
induced
via
inhibiting
phosphorylation
PI3K,
AKT,
mTOR
to
promote
replication.
activation
or
inhibition
PI3K
resulted
enhancing
reducing
replication,
respectively.
Further
revealed
interacted
with
cellular
autophagy.
present
study
PI3K/AKT
signaling
pathway
enhance
improve
understanding
molecular
offer
new
perspectives
for
development
effective
treatment
prevention
strategies.
Journal of Cellular Physiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 17, 2024
Abstract
Fibrosis,
an
aberrant
reparative
response
to
tissue
injury,
involves
a
disruption
in
the
equilibrium
between
synthesis
and
degradation
of
extracellular
matrix,
leading
its
excessive
accumulation
within
normal
tissues,
culminating
organ
dysfunction.
Manifesting
terminal
stages
nearly
all
chronic
ailments,
fibrosis
carries
high
mortality
rate
poses
significant
threat
human
health.
Heme
oxygenase‐1
(HO‐1)
emerges
as
endogenous
protective
agent,
mitigating
damage
through
antioxidant,
anti‐inflammatory,
antiapoptotic
properties.
Numerous
studies
have
corroborated
HO‐1's
potential
therapeutic
target
anti‐fibrosis
treatment.
This
review
delves
into
structural
functional
attributes,
upstream
downstream
pathways
HO‐1.
Additionally,
regulatory
networks
mechanisms
HO‐1
cells
associated
with
are
elucidated.
The
role
various
fibrosis‐related
diseases
is
also
explored.
Collectively,
this
comprehensive
information
serves
foundation
for
future
research
augments
viability
fibrosis.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 84 - 84
Опубликована: Дек. 25, 2024
Canine
distemper
(CD)
is
a
highly
infectious
disease
of
dogs
which
caused
by
canine
virus
(CDV).
Previous
studies
have
demonstrated
that
CDV
infection
can
induce
autophagy
in
cells.
However,
the
mechanism
underlying
CDV-induced
remains
not
fully
understood.
The
non-structural
protein
V
plays
vital
role
viral
replication
and
pathogenicity
host.
In
this
study,
we
investigated
relationship
between
CDV-V
induction
further
explored
its
impact
on
behind
this.
Our
results
showed
induced
via
inhibiting
phosphorylation
PI3K,
AKT,
mTOR
to
promote
replication.
activation
or
inhibition
PI3K
resulted
enhancing
reducing
replication,
respectively.
Further
revealed
interacted
with
cellular
autophagy.
present
study
PI3K/AKT
signaling
pathway
enhance
improve
understanding
molecular
offer
new
perspectives
for
development
effective
treatment
prevention
strategies.
