Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown
Опубликована: Сен. 24, 2024
Язык: Английский
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Авг. 26, 2024
Sepsis is a syndrome precipitated by immune dysregulation in response to infection, and represents pivotal factor global mortality attributed diseases. The recent consensus delineates sepsis as perilous state of organ dysfunction arising from the host’s maladaptive reaction infection. It masks complexity breadth mechanisms involved sepsis, which characterized simultaneous hyperinflammation immunosuppression. highly correlated with response, mainly mediated various cells their interactions. This can lead plethora complications, encompassing systemic inflammatory metabolic disturbances, infectious shock, MODS, DIC. Furthermore, more research studies have been conducted on past few years. pathological characteristics improved or treated targeting signaling pathways like NF-B, JAK–STAT, PI3K-Akt, p38-MAPK. Combined drug therapy better than single for sepsis. article will review latest progress pathogenesis treatment
Язык: Английский
Процитировано
6
Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 5855 - 5869
Опубликована: Авг. 1, 2024
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represent a spectrum of common critical conditions characterized by damage death alveolar epithelial cells (AECs). Pyroptosis is form programmed cell with inflammatory characteristics, activation pyroptosis markers has been observed in AECs patients ALI/ARDS. Lipopolysaccharides (LPS) possess strong pro-inflammatory effects are crucial pathological factor leading to ALI animals. In LPS-induced models, undergo pyroptosis. However, physiologically pathologically relevant concentrations LPS lead minor on AEC viability minimal induction cytokine release vitro do not induce classical Nevertheless, can enter the cytoplasm directly non-classical when assisted extracellular vesicles from bacteria, HMGB1, pathogens. this review, we have explored concerning inflammation, viability, pyroptosis, analyzing key factors that influence actions. Notably, highlight intricate response within framework ARDS, emphasizing variable Despite vitro, under specific conditions, presenting potential pathways for therapeutic intervention. Collectively, understanding these mechanisms development targeted treatments mitigate responses ALI/ARDS, thereby enhancing patient outcomes severe conditions.
Язык: Английский
Процитировано
4
Frontiers in Medicine, Год журнала: 2025, Номер 11
Опубликована: Янв. 22, 2025
Objective This study aims to conduct a bibliometric analysis assess the present state, thematic focus, and emerging developments in research literature on involvement of pyroptosis pathogenesis treatment acute lung injury (PFALI), as well other pertinent areas. Methods examined PFALI published from 1 January 2004 24 May 2024, utilizing Web Science database. The was conducted using CiteSpace, VOSviewer, R, GraphPad Prism 8.0, encompassed metadata countries, institutions, authors, journals, keywords represented literature. Results analyzed 1,495 publications, comprising 1,194 articles 301 reviews, publication output PFALI. China exhibited highest with 964 (64.48%) articles. Central South University most prolific institution, contributing 54 (3.61%) publications. Zhou, Yong had greatest individual record, 15 (3.59%) journal International Immunopharmacology PFALI-related at 76 (5.09%). identified frontiers for upcoming years include “iron,” “sirt1,” “repair,” “alveolar macrophage pyroptosis.” Conclusion comprehensively trends advancements related PFALI, including contributions key countries.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(5), С. 341 - 341
Опубликована: Фев. 26, 2025
Mesenchymal stem/stromal cells (MSCs) offer promising therapeutic potential in cell-based therapies for various diseases. However, the safety of genetically modified MSCs remains poorly understood. This study aimed to evaluate general toxicity and Wharton's Jelly-Derived (WJ-MSCs) engineered express antimicrobial peptide SE-33 an animal model. Genetically WJ-MSCs expressing were administered C57BL/6 mice at both excessive doses, either once or repeatedly. Animal monitoring included mortality, clinical signs, behavioral observations. The assessment involved histopathological, hematological, biochemical analyses major organs tissues, while immunotoxicity immunogenicity examined through humoral cellular immune responses, macrophage phagocytic activity, lymphocyte blast transformation. Antimicrobial efficacy was evaluated a Staphylococcus aureus-induced pneumonia model by mortality assessing bacterial load inflammatory processes lungs. Mice receiving exhibited no acute chronic toxicity, abnormalities, pathological changes, regardless dose administration frequency. No significant alterations responses observed, there notable changes hematological serum parameters. Infected animals treated with WJ-MSC-SE33 showed reduction lung inflammation improved survival compared control groups, demonstrating over native WJ-MSCs. Our findings suggest that are well tolerated, displaying favorable profile comparable potent significantly reducing load, inflammation, S. aureus These data support as candidate infections, particularly those complicated antibiotic resistance.
Язык: Английский
Процитировано
0
Peptides, Год журнала: 2025, Номер 187, С. 171381 - 171381
Опубликована: Март 8, 2025
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 154, С. 114560 - 114560
Опубликована: Апрель 7, 2025
Язык: Английский
Процитировано
0
Acta Biochimica et Biophysica Sinica, Год журнала: 2024, Номер unknown
Опубликована: Сен. 6, 2024
Acute lung injury (ALI) is a severe pulmonary disorder of sepsis with high clinical incidence and mortality. Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)-cysteinyl aspartate specific proteinase 1-gasdermin D (GSDMD)-dependent pyroptosis alveolar epithelial cells (AECs) has emerged as crucial contributor to ALI during sepsis. Phillyrin (PHI), natural lignan isolated from the traditional Chinese herbal medicine
Язык: Английский
Процитировано
3
Open Life Sciences, Год журнала: 2024, Номер 19(1)
Опубликована: Янв. 1, 2024
Sepsis-induced acute lung injury is associated with epithelial cell injury. This study analyzed the role of antimicrobial peptide LL37 mitochondrial DNA (LL37-mtDNA) and its potential mechanism action in lipopolysaccharide (LPS)-treated rat type II alveolar cells (RLE-6TN cells). RLE-6TN were treated LPS alone or LL37-mtDNA, followed by transcriptome sequencing. Differentially expressed pivotal genes screened using bioinformatics tools. The effects LL37-mtDNA on viability, inflammation, apoptosis, reactive oxygen species (ROS) production, autophagy-related hallmark expression evaluated LPS-treated cells. Additionally, Hsp90aa1 silencing following treatment investigated vitro. further suppressed augmented promoted release inflammatory cytokines, increased ROS elevated LC3B Using sequencing bioinformatics, ten candidate identified, which three core verified to be upregulated + group. downregulation attenuated possibly acted as a crucial target counteract autophagy activation
Язык: Английский
Процитировано
0
Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
0