Targeting SLC7A11 ameliorates ulcerative colitis by promoting efferocytosis through the ERK1/2 pathway
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Objective
and
design:
This
study
investigates
the
effect
underlying
mechanism
of
targeting
SLC7A11
in
mitigating
dextran
sulfate
sodium
(DSS)-induced
intestinal
inflammation
injury
colitis.
Methods:
We
utilized
wild-type
SLC7A11
-/+
mice
to
assess
inflammatory
damage
DSS-induced
colitis
vivo.
In
vitro,
colon
tissues
from
patients
with
ulcerative
were
analyzed
compare
expression
between
inflamed
non-inflamed
regions.
Further
mechanistic
insights
obtained
using
Caco-2
cells
bone
marrow-derived
dendritic
(BMDCs).
Results:
In
human
tissues,
was
significantly
elevated
regions
compared
areas,
particularly
cells.
vivo
inhibition
markedly
alleviated
symptoms.
suppressing
restored
integrity
monolayer
epithelial
model.
Both
knockout
enhanced
ERK1/2
phosphorylation
increased
efferocytosis
BMDCs.
Conclusions:
Targeting
augments
cell
preserves
barrier
function,
potentially
offering
a
therapeutic
avenue
for
alleviating
Язык: Английский
Targeting SLC7 A11 Ameliorates Ulcerative Colitis by Promoting Efferocytosis Through the ERK1/2 Pathway
Inflammation,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
Язык: Английский
Clarifying new molecular subtyping and precise treatment of melanoma based on disulfidptosis-related lncRNA signature
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Сен. 28, 2024
Язык: Английский