Asperdoles A–N: Indole Diterpenoids from the Endolichenic Fungus Aspergillus sp. TJ403-YJ22 DOI
Jun Yao, Chenyang Wang,

Hanxiao Zeng

и другие.

Journal of Natural Products, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Fourteen new indole diterpenoids, designated as asperdoles A-N (1-14), were isolated from the endolichenic fungus Aspergillus sp. TJ403-YJ22. Notably, compounds 1-7 characterized by presence of 2-keto-3-hydroxy-oxidized moieties, which connected to diterpenoid segments via methylene bridges. Compounds 1-5 featured fused 6/6/6 ring frameworks, whereas tetrahydropyran in 6-14 was cleaved, resulting formation terminal vicinal diols 6-12 and olefinic double bonds 13 14. The planar structures absolute configurations these elucidated through a combination NMR spectroscopy, HRESIMS, Snatzke's method, single-crystal X-ray diffraction analysis, ECD calculations. Compound 4 exhibited selective FXR agonistic activity, with an EC50 value 4.1 ± 0.3 μM, suggesting its potential therapeutic application treatment cholestasis.

Язык: Английский

Asperdoles A–N: Indole Diterpenoids from the Endolichenic Fungus Aspergillus sp. TJ403-YJ22 DOI
Jun Yao, Chenyang Wang,

Hanxiao Zeng

и другие.

Journal of Natural Products, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Fourteen new indole diterpenoids, designated as asperdoles A-N (1-14), were isolated from the endolichenic fungus Aspergillus sp. TJ403-YJ22. Notably, compounds 1-7 characterized by presence of 2-keto-3-hydroxy-oxidized moieties, which connected to diterpenoid segments via methylene bridges. Compounds 1-5 featured fused 6/6/6 ring frameworks, whereas tetrahydropyran in 6-14 was cleaved, resulting formation terminal vicinal diols 6-12 and olefinic double bonds 13 14. The planar structures absolute configurations these elucidated through a combination NMR spectroscopy, HRESIMS, Snatzke's method, single-crystal X-ray diffraction analysis, ECD calculations. Compound 4 exhibited selective FXR agonistic activity, with an EC50 value 4.1 ± 0.3 μM, suggesting its potential therapeutic application treatment cholestasis.

Язык: Английский

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