Role of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease Pathogenesis: Updates and Perspectives

Immuno, Год журнала: 2025, Номер 5(2), С. 13 - 13

Опубликована: Апрель 15, 2025

Chronic obstructive pulmonary disease (COPD) is a chronic, debilitating condition that affects the lungs and airways. It characterized by persistent bronchitis, exemplified inflammation of bronchial tubes, hypersecretion mucus, emphysema, destruction airway parenchyma. The combination these conditions leads to tissue damage, fibrosis, ongoing inflammatory response in COPD complex process orchestrated wide range immune cells. These include lung epithelial cells, monocytes, macrophages, neutrophils, eosinophils, T B lymphocytes, among others. cells work together produce biomarkers are involved pathogenesis COPD. Some key have been identified variety cytokines, C-reactive protein/serum albumin ratio, fibrinogen, soluble receptor for advanced glycation endproducts, club/clara with molecular weight 16 kDa, surfactant protein D, adiponectin, reactive oxygen species, proteases. This review aims provide comprehensive overview role development progression will delve into intricacies COPD, exploring various cell types this process. By understanding underlying mechanisms drive we can better develop targeted treatments help alleviate symptoms

Язык: Английский

Esketamine mitigates mechanical ventilation-induced lung injury in chronic obstructive pulmonary disease rats via inhibition of the MAPK/NF-κB signaling pathway and reduction of oxidative stress

International Immunopharmacology, Год журнала: 2024, Номер 139, С. 112725 - 112725

Опубликована: Июль 25, 2024

To investigate esketamine's impact on inflammation and oxidative stress in ventilated chronic obstructive pulmonary disease (COPD) rats, examining its regulatory mechanisms.

Язык: Английский

<i>Gnaphalium Affine</i>&nbsp;Alleviates Chronic Obstructive Pulmonary Disease by Antioxidants and Produces Changes in the Gut Microbiota

Опубликована: Янв. 1, 2024

Язык: Английский