Synthesis of Carbon Dots from Spent Coffee Grounds: Transforming Waste into Potential Biomedical Tools

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Carbon dots were synthesised from spent coffee grounds via a novel acetone precipitation approach, featuring superior physico-chemical properties for potential biomedical applications. Created in BioRender. Zhou, Y. (2025) https://BioRender.com/m82x982.

Язык: Английский

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Structural characterization and antioxidant activity mechanism of the ferulic acid-rich subfraction from sugar beet pectin

Carbohydrate Polymers, Год журнала: 2024, Номер 347, С. 122691 - 122691

Опубликована: Авг. 30, 2024

Язык: Английский

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Cistanche deserticola polysaccharides—Companilactobacillus crustorum LBK 1001 complex relieves aging in Caenorhabditis elegans

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106486 - 106486

Опубликована: Март 1, 2025

Язык: Английский

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A Comprehensive Review on Carbon Dot Synthesis and Food Applications

Journal of Agriculture and Food Research, Год журнала: 2025, Номер unknown, С. 101847 - 101847

Опубликована: Апрель 1, 2025

Язык: Английский

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Are food-derived carbon dots really edible? A potential harm versus potential benefits analysis

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 105031 - 105031

Опубликована: Апрель 1, 2025

Язык: Английский

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Antibiotic treatment induces microbiome dysbiosis and reduction of neuroinflammation following traumatic brain injury in mice.

Опубликована: Май 12, 2024

Abstract The gut microbiome is linked to brain pathology in cases of traumatic injury (TBI), yet the specific bacteria that are implicated not well characterized. To address this gap, study, we induced (TBI) male C57BL/6J mice using controlled cortical impact (CCI) model. After 35 days, administered a broad-spectrum antibiotics (ABX) cocktail (ampicillin, gentamicin, metronidazole, vancomycin) through oral gavage for 2 days diminish existing microbiota. Subsequently, inflicted second TBI on and analyzed neuropathological outcomes five later. Longitudinal analysis showed significant shifts diversity abundance bacterial genera during both acute chronic inflammation. These changes were particularly dramatic following treatment with ABX after TBI. did affect production short-chain fatty acids (SCFA) but alter intestinal morphology, characterized by reduced villus width lower count goblet cells, suggesting potential negative impacts integrity. Nevertheless, diminishing damage, apoptotic cell density, microglial/macrophage activation thalamic regions brain. Our findings suggest eliminating colonized via reduces neuroinflammation enhances neurological despite implications health.

Язык: Английский

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Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 27, 2024

Abstract Background Ulcerative colitis (UC) is a chronic intestinal inflammation, resulting in global healthcare challenge with no real specific medicine. Natural medicines are recognized as potential clinical alternative therapy, but their applications limited by poor solubility and low bioavailability. Results In this work, inspired the natural of ancient China, novel functional carbon dots derived from Magnetite Medicated Leaven (MML-CDs) were synthesized hydrothermal method, confirmed ultrasmall nano-size (3.2 ± 0.6 nm) Fe doped surface structure, thereby excellent gastrointestinal stability, remarkable capabilities eliminating ROS, highly biocompatibility. With external stimuli, oral administration MML-CDs demonstrated obvious alleviation to UC. Further experiments pointed that could improve hemostasis capability, suppress inflammation reactions oxidative stress, up-regulate expression tight junction proteins. Furthermore, also showed well regulation dysbiosis flora. Conclusion Overall, above evidence reveals green-synthesized can significantly alleviate bleeding, inhibit colon repair colonic barrier damage, further regulating flora microenvironment. Our findings provide an efficient therapy strategy for ulcerative colitis. Graphical

Язык: Английский

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Antioxidant Carbon Dots Nanozymes Alleviate Stress-induced Depression by Modulating Gut Microbiota

Langmuir, Год журнала: 2024, Номер 40(37), С. 19739 - 19750

Опубликована: Сен. 2, 2024

Depression is a debilitating mental illness that severely threatens millions of individuals and public health. Because the multifactorial etiologies, there currently no cure for depression; thus, it urgently imperative to find alternative antidepressants strategies. Growing evidence underscores prominent role oxidative stress as key pathological hallmarks depression, making potential therapeutic target. In this study, we report N-doped carbon dot nanozyme (CDzyme) with excellent antioxidant capacity treating depression by remodeling redox homeostasis gut microbiota. The CDzymes prepared via microwave-assisted fast polymerization histidine glucose exhibit superior biocompatibility. Benefiting from unique structure, can provide abundant electrons, hydrogen atoms, protons reducing reactions, well catalytic sites mimic enzymes. These mechanisms collaborating endow broad-spectrum scavenge reactive oxygen nitrogen species (

Язык: Английский

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Antibiotic treatment induces microbiome dysbiosis and reduction of neuroinflammation following traumatic brain injury in mice

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 11, 2024

Background The gut microbiome is linked to brain pathology in cases of traumatic injury (TBI), yet the specific bacteria that are implicated not well characterized. To address this gap, study, we induced (TBI) male C57BL/6J mice using controlled cortical impact (CCI) model. After 35 days, administered a broad-spectrum antibiotics (ABX) cocktail (ampicillin, gentamicin, metronidazole, vancomycin) through oral gavage for 2 days diminish existing microbiota. Subsequently, inflicted second TBI on and analyzed neuropathological outcomes five later. Results Longitudinal analysis showed significant shifts diversity abundance bacterial genera during both acute chronic inflammation. These changes were particularly dramatic following treatment with ABX after TBI. did affect production short-chain fatty acids (SCFA) but alter intestinal morphology, characterized by reduced villus width lower count goblet cells, suggesting potential negative impacts integrity. Nevertheless, diminishing damage, apoptotic cell density, microglial/macrophage activation thalamic regions brain. Conclusions Our findings suggest eliminating colonized via reduces neuroinflammation enhances neurological despite implications health.

Язык: Английский

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Structural Characterization and Antioxidant Activity Mechanism of the Feruloylated Neutral Sugar Side Chain from Sugar Beet Pectin

Опубликована: Янв. 1, 2024

Язык: Английский

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