Expert Review of Proteomics, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Objectives Cartilage defects (CDs) are regarded as early manifestation of osteoarthritis (OA). The infrapatellar fat pad (IPFP) is an important mediator in maintaining joint homeostasis, disease progression and tissue repair, with a crucial role its secreted proteins. Here, we investigate the proteome IPFP relation to clinical status response surgical treatment CDs.
Язык: Английский
Biomedicines, Год журнала: 2024, Номер 12(4), С. 923 - 923
Опубликована: Апрель 22, 2024
This review critically evaluates advancements in multifunctional hydrogels, particularly focusing on their applications osteoarthritis (OA) therapy. As research evolves from traditional natural materials, there is a significant shift towards synthetic and composite known for superior mechanical properties enhanced biodegradability. spotlights novel such as injectable microneedle technology, responsive which have revolutionized OA treatment through targeted efficient therapeutic delivery. Moreover, it discusses innovative hydrogel including protein-based superlubricating potential to reduce joint friction inflammation. The integration of bioactive compounds within hydrogels augment efficacy also examined. Furthermore, the anticipates continued technological deeper understanding hydrogel-based therapies. It emphasizes provide tailored, minimally invasive treatments, thus highlighting critical role advancing dynamic field biomaterial science management.
Язык: Английский
Процитировано
15
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117364 - 117364
Опубликована: Сен. 2, 2024
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration. It whole organ characterized by cartilage degeneration and varying degrees of synovitis, involving pathological changes all tissues, such as cartilage, subchondral bone, ligaments, meniscus, synovium, infrapatellar fat pad (IPFP). IPFP the largest adipose tissue structure knee composed cells, immune cells blood vessels. Moreover, located close to bone surface so that it may reduce impact loading absorb forces generated through joint, have protective role health. has been shown release various cytokines adipokines play pro-inflammatory pro-catabolic roles promoting OA progression. Intra-articular injections IPFP-derived mesenchymal stem exosomes pain prevent progression patients with OA. Previous studies biphasic effect on This article reviews latest research progress IPFP, discusses mechanism OA, provide new intervention strategies for treatment will also discuss handling during procedure total arthroplasty.
Язык: Английский
Процитировано
6
Journal of Orthopaedic Translation, Год журнала: 2025, Номер 53, С. 1 - 11
Опубликована: Май 28, 2025
Язык: Английский
Процитировано
0
Expert Review of Proteomics, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Objectives Cartilage defects (CDs) are regarded as early manifestation of osteoarthritis (OA). The infrapatellar fat pad (IPFP) is an important mediator in maintaining joint homeostasis, disease progression and tissue repair, with a crucial role its secreted proteins. Here, we investigate the proteome IPFP relation to clinical status response surgical treatment CDs.
Язык: Английский
Процитировано
2