Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers

Human Genomics, Год журнала: 2025, Номер 19(1)

Опубликована: Фев. 7, 2025

Sideroflexin (SFXN) family genes encode for a group of mitochondrial proteins involved in cellular processes such as iron homeostasis, amino acid metabolism, and energy production. Recent studies showed that they were aberrantly expressed certain human cancers. However, there is paucity information about their expression prostate cancer. In this study, we took comprehensive approach to investigate profiles benign tissue, prostate-derived cell lines, cancer tissues using multiple transcriptome datasets. Our results SFXN1/3/4 predominantly tissue lines. SFXN2/4 significantly upregulated while the SFXN3 was downregulated malignant compared tissues. SFXN4 identified diagnostic biomarker prognostic factor unfavorite survival outcomes. advanced cancers, expressions positively correlated with androgen receptor signaling activity but negatively neuroendocrinal features. Further analysis discovered SFXN5 elevated conclusion, are novel biomarkers diagnosis prognosis.

Язык: Английский

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CCL20 in the tumor microenvironment: implications for cancer progression and therapeutic approaches

Clinical & Translational Oncology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract Increasing knowledge of the immunosuppressive tumor microenvironment in cancer-related processes has led to developing novel immune-based therapies that have changed cancer treatment paradigm. In microenvironment, plethora soluble factors secreted by cells interacts with immune and non-immune components deliver signals necessary for progression. Accordingly, targeting tumor-derived inducing this become an appealing therapeutic potential advancing treatment. CCL20, a chemokine best known induce leucocyte migration response pathological inflammatory conditions, been implicated proliferation, angiogenesis, metastasis, immunosuppression, resistance. Notably, CCL20 its receptor CCR6 are important interactions. This review discusses interaction between CCL20–CCR6 axis how these interactions promote Also, outline studies utilizing combination other standard treatments shed.

Язык: Английский

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Bidirectional Mendelian randomization and potential mechanistic insights into the causal relationship between gut microbiota and malignant mesothelioma

Medicine, Год журнала: 2025, Номер 104(17), С. e42245 - e42245

Опубликована: Апрель 25, 2025

Malignant mesothelioma (MM) is a rare but aggressive cancer originating from mesothelial cells, which presents significant challenges to patients’ physical and psychological well-being. The gut–lung axis underscores the connection between gut microbiota respiratory diseases, with emerging evidence suggesting strong association development of MM. In this study, we conducted two-sample Mendelian randomization (MR) analysis investigate potential causal relationship MM, while also exploring underlying mechanisms through bioinformatics approaches. Gut summary data were obtained MiBioGen consortium, MM sourced FinnGen R11 dataset. Causality was examined using inverse variance weighted method as primary analysis. Additional methods, including median, simple mode, MR-Egger, employed. robustness findings validated sensitivity analyses, reverse causality considered further strengthen MR results. Moreover, analyses on genetic loci associated both explore mechanisms. Our study suggests that genetically predicted increases in class.Bacilli , family.Rikenellaceae genus.Clostridium innocuum group order.Lactobacillales suggestively higher risk whereas genus.Ruminococcaceae UCG004 genus.Flavonifractor phylum.Firmicutes genus.Anaerofilum sensu stricto 1 genus.Lactobacillus appeared confer protective effects. Bioinformatics indicated differentially expressed genes near might affect by modulating pathways tumor microenvironment. results point predisposition linking Further experimental validation crucial confirm these candidate microbes, establish causality, elucidate

Язык: Английский

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CCL20-CCR6 signaling in tumor microenvironment: Functional roles, mechanisms, and immunotherapy targeting

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189341 - 189341

Опубликована: Май 1, 2025

Язык: Английский

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