Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages DOI Creative Commons
Yuchen Ma,

Xiaoli Qian,

Qun Yu

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 123 - 123

Опубликована: Дек. 31, 2024

Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the effects inosine, particularly its ability to inhibit development colorectal cancer (CRC) cells CT26 through modulation macrophage phenotypes. Aside from already reported inosine on T cells, in this study, vitro experiments revealed that could modulate phenotype. The M1/M2 polarization were investigated at cellular level. Its role regulating CRC proliferation and migration was further examined. In addition, tumor mouse model established assess mechanism action by weight measurement, immunohistochemistry, immunofluorescence. significantly increased M1 markers CD86 iNOS enhanced anti-tumor activity macrophages, effectively inhibiting progression metastasis potential. vivo, had significant inhibitory activity. It also reduced expression Ki-67 promoted macrophages.

Язык: Английский

Targeting tumor-associated macrophages in colon cancer: mechanisms and therapeutic strategies DOI Creative Commons

Jianqin Xiang,

Jian Wang, Huihui Xiao

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

Colon cancer (CC) remains a primary contributor to cancer-related fatalities worldwide, driven by difficulties in early diagnosis and constrained therapeutic options. Recent studies underscore the importance of tumor microenvironment (TME), notably tumor-associated macrophages (TAMs), fostering malignancy progression therapy resistance. Through their inherent plasticity, TAMs facilitate immunosuppression, angiogenic processes, metastatic spread, drug tolerance. In contrast M1 macrophages, which promote inflammatory tumoricidal responses, M2 support expansion dissemination exerting immunosuppressive pro-angiogenic influences. Consequently, manipulating has emerged as potential avenue enhance treatment effectiveness. This review outlines origins, polarization states, functions CC, highlights role driving advancement, surveys ongoing efforts target these cells for better patient outcomes. Emerging strategies aimed at modulating TAM - including depletion strategies, reprogramming approaches that shift M2-polarized toward an phenotype, inhibition key signaling pathways sustaining TAM-mediated immunosuppression-are currently under active investigation. These hold promise overcoming induced resistance improving immunotherapeutic efficacy CC.

Язык: Английский

Процитировано

0

Mathematical modeling and Hopf bifurcation analysis of tumor macrophage interaction with polarization delay DOI Creative Commons
Jianping Li, Nan Liu, Danni Wang

и другие.

Journal of Biological Dynamics, Год журнала: 2025, Номер 19(1)

Опубликована: Май 26, 2025

Macrophages have both anti-tumor and pro-tumor effects. Time delay is commonly observed in real systems, yet its impact on tumor-macrophage dynamics remains unclear. This paper develops a new model with time delay. The describes the interactions between tumor cells (T), classically activated macrophages (M1), alternatively (M2), inactive (M0). system's solution computed, equilibrium stability analyzed. existence of Hopf bifurcation subsequently established. There exists bifurcating periodic solutions near internal equilibrium, showing can coexist long term, as well potential for relapse. Furthermore, normal form center manifold theorem are utilized to study nature bifurcation. Sensitivity analysis highlights effect parameters population dynamics. Numerical simulations validate theory, elaborating serve useful tool system analysis.

Язык: Английский

Процитировано

0

Regulation and Function of Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): The Role of the SRIF System in Macrophage Regulation DOI Open Access

Agnieszka Geltz,

Jakub Geltz, Aldona Kasprzak

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5336 - 5336

Опубликована: Июнь 1, 2025

Colorectal cancer (CRC) remains the leading cause of morbidity and mortality for both men women worldwide. Tumor-associated macrophages (TAMs) are most abundant immune cells in tumor microenvironment (TME) solid tumors, including CRC. These found pro-inflammatory M1 anti-inflammatory M2 forms, with latter increasingly recognized its tumor-promoting phenotypes. Many signaling molecules pathways, AMPK, EGFR, STAT3/6, mTOR, NF-κB, MAPK/ERK, HIFs, involved regulating TAM polarization. Consequently, researchers investigating several potential predictive prognostic markers, novel TAM-based therapeutic targets, especially combination therapies Macrophages gastrointestinal tract, normal colon rectum, produce growth hormone-releasing inhibitory peptide/somatostatin (SRIF/SST) five SST receptors (SSTRs, SST1-5). While immunosuppressive function SRIF system is primarily known various tissues, role within CRC-associated TAMs underexplored. This review focuses on following three aspects TAMs: first, rectum broader context macrophage biology; second, bioactive factors pathways associated function, along strategies targeting CRC; third, interaction between tissues CRC microenvironment.

Язык: Английский

Процитировано

0

Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages DOI Creative Commons
Yuchen Ma,

Xiaoli Qian,

Qun Yu

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 123 - 123

Опубликована: Дек. 31, 2024

Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the effects inosine, particularly its ability to inhibit development colorectal cancer (CRC) cells CT26 through modulation macrophage phenotypes. Aside from already reported inosine on T cells, in this study, vitro experiments revealed that could modulate phenotype. The M1/M2 polarization were investigated at cellular level. Its role regulating CRC proliferation and migration was further examined. In addition, tumor mouse model established assess mechanism action by weight measurement, immunohistochemistry, immunofluorescence. significantly increased M1 markers CD86 iNOS enhanced anti-tumor activity macrophages, effectively inhibiting progression metastasis potential. vivo, had significant inhibitory activity. It also reduced expression Ki-67 promoted macrophages.

Язык: Английский

Процитировано

1