Bioorganic Chemistry, Год журнала: 2024, Номер 155, С. 108119 - 108119
Опубликована: Дек. 30, 2024
Язык: Английский
International Journal of Medical Sciences, Год журнала: 2025, Номер 22(4), С. 955 - 970
Опубликована: Янв. 27, 2025
Rationale: Tubulointerstitial fibrosis is a key pathological aspect of diabetic nephropathy (DN) linked to reduced kidney function. Recent research has identified varied functions the sigma-1 receptor (S1R) in processes cardiac, pulmonary, and trabecular meshwork tissues. Nonetheless, specific roles S1R renal remain inadequately understood. Objective: This study sought examine pathogenesis diabetes-induced fibrosis, as well elucidate underlying mechanisms involved. Materials methods: expression was found DN patients, db/db mice, HG-treated HK-2 cells. Loss-of-function studies confirmed S1R's role nuclear factor erythroid 2-related 2 (NRF2) pathway-mediated ferroptosis fibrosis. Molecular docking co-immunoprecipitation (CO-IP) analysis explored S1R-NRF2 interaction. Results: primarily tubular epithelial cells up-regulated HG-cultured inhibition alleviated HG stimulated cells, while knockdown NRF2 further abolishes these protective effects by inhibition. As for mechanism, combined with could increase translocation up-regulate phosphorylated (p-NRF2), finally ameliorate ferroptosis-mediated Conclusions: In DN, kidneys significantly elevated. It increases p-NRF2 expression, which inhibits translocation, promoting resulting
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114341 - 114341
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(6), С. 1275 - 1275
Опубликована: Март 12, 2025
Natural products have emerged as crucial sources of biologically active compounds, holding promise for applications in drug development. Among the extensively researched pentacyclic triterpenes, hederagenin (HG) stands out its diverse biological activities and serves a valuable scaffold synthesizing novel derivatives. These derivatives hold significant development therapeutic agents aimed at treating wide range diseases. Over past years, multitude HG with varied bioactivities been synthesized through chemical modifications. This review article consolidates most recent findings (since 2017) on derivatives, emphasizing their effects mechanisms action both vitro vivo models. The objective this compilation is to offer insights direct future research endeavors realm HG.
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114463 - 114463
Опубликована: Март 20, 2025
Язык: Английский
Процитировано
0
Cell Biochemistry and Function, Год журнала: 2025, Номер 43(4)
Опубликована: Апрель 1, 2025
ABSTRACT Diabetic kidney disease (DKD) is a major diabetic microvascular complication that still lacks effective therapeutic drugs. Ferroptosis recently identified form of programmed cell death triggered by iron overload. It characterized unrestricted lipid peroxidation and subsequent membrane damage found in various diseases. Accumulating evidence has highlighted the crucial roles overload ferroptosis DKD. Here, we review metabolism biology ferroptosis. The role aberrant inducing diverse renal intrinsic death, oxidative stress, fibrosis DKD summarized, elaborate on critical regulatory factors related to Finally, focused significance treatment highlight recent data regarding novel activities some drugs as inhibitors DKD, aiming provide new research targets strategies
Язык: Английский
Процитировано
0
Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111841 - 111841
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2024, Номер 136, С. 156342 - 156342
Опубликована: Дек. 24, 2024
Язык: Английский
Процитировано
2
Biology, Год журнала: 2024, Номер 14(1), С. 12 - 12
Опубликована: Дек. 27, 2024
Chronic kidney disease (CKD) is a global health concern caused by conditions such as hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural functional injury. Kidney fibrosis common outcome of CKD progression, with abnormal fatty acid oxidation (FAO) disrupting renal energy homeostasis impairments. This results in maladaptive repair mechanisms the secretion profibrotic factors, exacerbates fibrosis. Understanding molecular crucial for delaying progression. Ferroptosis type discovered an iron-dependent lipid peroxidation-regulated cell death. Notably, contributes tissue organ fibrosis, which correlated degree study aims clarify complex ferroptosis parenchymal cells explore how intervention may help alleviate particularly addressing gap related metabolism under context. The goal provide new theoretical basis clinically
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13279 - 13279
Опубликована: Дек. 11, 2024
Renal fibrosis is a common final pathway underlying nearly almost all progressive kidney diseases. Metal ions are essential trace elements in organisms and involved important physiological activities. However, aberrations intracellular metal ion metabolism may disrupt homeostasis, causing cell death increasing susceptibility to various Accumulating evidence suggests complex association between metal-dependent renal fibrosis. In this article, we provide comprehensive overview of the specific molecular mechanisms their crosstalk, up-to-date supporting role fibrosis, therapeutic targeting strategies, research needs, aiming offer rationale for future clinical treatment
Язык: Английский
Процитировано
0
Bioorganic Chemistry, Год журнала: 2024, Номер 155, С. 108119 - 108119
Опубликована: Дек. 30, 2024
Язык: Английский
Процитировано
0