Association between body roundness index and rheumatoid arthritis: a cross-sectional study based on NHANES
Zong Jiang,
Xin Cai,
Xiaoling Yao
и другие.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Abstract
Background
The
Body
Roundness
Index
(BRI)
has
been
identified
as
a
potentially
superior
measure
of
body
fat
distribution
such
mass
index
(BMI)
and
waist
circumference
(WC).
However,
its
relationship
with
rheumatoid
arthritis
(RA)
yet
to
be
thoroughly
investigated.
This
study
examines
the
association
between
BRI
RA
risk
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods
analysis
included
28,559
adults,
excluding
those
missing
values
for
or
status.
was
calculated
height
WC
measurements,
while
self-reported
by
participants.
Multivariate
logistic
regression
utilized
assess
RA,
controlling
sociodemographic
variables
pertinent
comorbid
conditions.
Receiver
operating
characteristic
(ROC)
curves
area
under
curve
(AUC)
were
employed
predictive
accuracy
BRI,
BMI,
concerning
RA.
Results
An
elevated
demonstrated
notable
correlation
heightened
With
each
unit
increase
in
there
corresponding
10%
likelihood
after
complete
adjustment
(OR:
1.10,
95%
CI:
1.08–1.12,
P
<
0.001).
A
clear
dose-response
among
quartiles,
where
individuals
highest
quartile
exhibited
76%
increased
1.76,
1.50–2.07,
Subgroup
indicated
more
pronounced
participants
exhibiting
hyperlipidemia
(P
interaction
=
0.012).
Threshold
revealed
value
4.61
critical
inflection
point,
beyond
which
correlated
12%
1.12,
ROC
that
AUC
0.637
predicting
risk,
surpassing
at
0.622
BMI
0.594.
Conclusions
serves
strong
indicator
demonstrating
enhanced
when
contrasted
conventional
metrics
like
WC.
results
indicate
may
function
valuable
instrument
assessing
especially
hyperlipidemia.
Язык: Английский
Do Obesity and Adipose Tissue Cytokines Influence the Response to Janus Kinase Inhibitors in Rheumatoid Arthritis?
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 820 - 820
Опубликована: Фев. 27, 2025
Background:
Obesity
is
a
frequent
comorbidity
in
rheumatoid
arthritis
(RA).
This
condition
may
lead
these
patients
to
have
poorer
disease
control
and
worse
response
some
of
the
available
treatments.
Objectives:
We
aim
analyze
role
body
mass
index
(BMI)
clinical
Janus
kinase
inhibitors
(JAKis)
with
RA.
perform
an
in-depth
analysis
pathophysiology
obesity
by
assessing
serum
adipokine
levels,
their
potential
influence
activity
changes
treatment.
Methods:
study
involved
81
RA
treated
JAKis
from
Hospital
La
Paz
Reina
Sofía.
Patients
were
classified
according
BMI
as
normal
weight
overweight/obesity.
The
treatment
was
assessed
Clinical
Disease
Activity
Index
(CDAI)
Score-28
(DAS28)
6
months
after
initiation
JAKis.
Serum
adipokines
(leptin
adiponectin)
determined
using
commercial
immunoassay
kit
samples
obtained
before
Results:
Leptin
levels
showed
significant
positive
correlation
at
baseline
(r
=
0.59,
p
<
0.01)
0.56,
whole
cohort,
but
no
found
between
adiponectin.
No
cohort
measured
both
CDAI
DAS28.
Fifty
(61.7%)
achieved
low
(LDA)/remission
months,
regardless
BMI,
differences
observed
who
LDA
vs.
no-LDA.
Conclusions:
In
this
study,
we
did
not
find
association
extent
JAKis;
therefore,
mechanism
action
could
be
suitable
for
overweight/obese
Язык: Английский
Association of visceral fat metabolism score with risk of rheumatoid arthritis in US adults
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Март 20, 2025
Background
The
Visceral
Adiposity
Index
(METS-VF)
has
emerged
as
a
novel
obesity
assessment
metric.
However,
research
exploring
the
relationship
between
METS-VF
and
rheumatoid
arthritis
(RA)
remains
limited.
objective
of
this
investigation
was
to
examine
correlation
prevalence
RA
METS-VF.
Methods
NHANES
data
collected
2011
2018
were
used
in
investigation.
To
determine
association
RA,
logistic
regression
analysis
used.
Sensitivity
subgroup
done
test
how
reliable
results
were.
Finally,
predictive
power
BMI,
waist
circumference,
for
compared
using
ROC
curve
analysis.
Results
This
had
8,626
individuals
total.
findings
showed
that
those
without
persons
with
condition
noticeably
greater
levels.
significantly
positively
correlated,
according
(OR
=
1.50,
95%
CI
1.12–2.00).
sensitivity
analyses
agreed
primary
conclusions.
indicated
possessed
superior
ability
predict
BMI
circumference.
Conclusion
study
indicates
elevated
levels
are
correlated
an
increased
risk
US
population.
Monitoring
metric
might
aid
early
detection
high-risk
patients.
Язык: Английский
Blockade of IL-1 family cytokines in the treatment of rheumatoid arthritis
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 30, 2025
Rheumatoid
arthritis
(RA),
a
chronic
autoimmune
disorder,
imposes
substantial
global
health
burden
through
elevated
disability
rates,
systemic
complications,
and
socioeconomic
consequences.
Chronic
synovitis
progressive
joint
destruction
characterize
this
disease,
driven
by
dysregulated
innate
adaptive
immune
responses
that
amplify
synovial
inflammation,
osteoclastogenesis,
irreversible
tissue
damage.
Aberrant
activation
of
interleukin
(IL)
-1
family
cytokines
critically
contributes
to
RA
pathogenesis.
These
mediate
dual
mechanisms:
pro-inflammatory
agonists
like
IL-1β,
IL-18,
IL-36
accelerate
disease
progression,
whereas
insufficient
levels
anti-inflammatory
antagonists
such
as
IL-1Ra
IL-37
disrupt
the
balance
required
suppress
pathogenic
cascades.
Clinical
trials
evaluating
IL-1-targeting
biologics—including
anakinra
canakinumab—have
demonstrated
robust
early
efficacy.
However,
late-stage
interventions
exhibit
diminished
therapeutic
returns,
largely
due
damage
compensatory
redundant
cytokine
networks.
findings
emphasize
need
for
precise
patient
stratification.
Single-pathway
IL-1
inhibition
faces
inherent
limitations,
driving
development
multi-target
strategies
counteract
redundancy
reduce
resistance.
This
review
systematically
analyzes
mechanistic
roles
in
RA,
evaluates
clinical
outcomes
safety
profiles
IL-1-targeted
therapies,
proposes
innovative
advance
treatment.
Язык: Английский
ROS-triggered and macrophage-targeted micelles modulate mitochondria function and polarization in obesity
Nanotechnology,
Год журнала:
2024,
Номер
35(47), С. 475707 - 475707
Опубликована: Сен. 6, 2024
Abstract
Inflammation
involving
adipose
macrophages
is
an
important
inducer
of
obesity.
Regulating
polarization
and
improving
the
inflammatory
microenvironment
tissue
a
new
strategy
for
treatment
An
amphiphilic
chondroitin
sulfate
phenylborate
derivative
(CS-PBE)
was
obtained
by
modifying
main
chain
with
hydrophobic
small
molecule
phenylborate.
Using
CS-PBE
self-assembly,
macrophage
targeting,
reactive
oxygen
species
(ROS)
release
celastrol
(CLT)
encapsulation
were
achieved.
The
cytotoxicity,
cellular
uptake,
internalization
pathways
transmembrane
transport
efficiency
micelles
studied
in
Caco-2
RAW264.7
cells.
Hemolysis
organotoxicity
tests
performed
to
assess
safety
platform,
while
its
therapeutic
efficacy
investigated
high-fat
diet-induced
obese
mice.
Multifunctional
targeting
ROS
clearance
capabilities
developed
improve
CLT
treating
In
vitro
studies
indicated
that
had
better
ability
target
M1
macrophages,
protective
effects
on
mitochondrial
function,
reduce
number
LPS-stimulated
M2
scavenge
macrophages.
vivo
have
shown
inflammation
significantly
toxicity
summary,
could
alleviate
inflammation,
suggesting
are
highly
promising
approach
Язык: Английский