Association between body roundness index and rheumatoid arthritis: a cross-sectional study based on NHANES

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Background The Body Roundness Index (BRI) has been identified as a potentially superior measure of body fat distribution such mass index (BMI) and waist circumference (WC). However, its relationship with rheumatoid arthritis (RA) yet to be thoroughly investigated. This study examines the association between BRI RA risk using data from National Health Nutrition Examination Survey (NHANES). Methods analysis included 28,559 adults, excluding those missing values for or status. was calculated height WC measurements, while self-reported by participants. Multivariate logistic regression utilized assess RA, controlling sociodemographic variables pertinent comorbid conditions. Receiver operating characteristic (ROC) curves area under curve (AUC) were employed predictive accuracy BRI, BMI, concerning RA. Results An elevated demonstrated notable correlation heightened With each unit increase in there corresponding 10% likelihood after complete adjustment (OR: 1.10, 95% CI: 1.08–1.12, P < 0.001). A clear dose-response among quartiles, where individuals highest quartile exhibited 76% increased 1.76, 1.50–2.07, Subgroup indicated more pronounced participants exhibiting hyperlipidemia (P interaction = 0.012). Threshold revealed value 4.61 critical inflection point, beyond which correlated 12% 1.12, ROC that AUC 0.637 predicting risk, surpassing at 0.622 BMI 0.594. Conclusions serves strong indicator demonstrating enhanced when contrasted conventional metrics like WC. results indicate may function valuable instrument assessing especially hyperlipidemia.

Язык: Английский

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Do Obesity and Adipose Tissue Cytokines Influence the Response to Janus Kinase Inhibitors in Rheumatoid Arthritis?

Nutrients, Год журнала: 2025, Номер 17(5), С. 820 - 820

Опубликована: Фев. 27, 2025

Background: Obesity is a frequent comorbidity in rheumatoid arthritis (RA). This condition may lead these patients to have poorer disease control and worse response some of the available treatments. Objectives: We aim analyze role body mass index (BMI) clinical Janus kinase inhibitors (JAKis) with RA. perform an in-depth analysis pathophysiology obesity by assessing serum adipokine levels, their potential influence activity changes treatment. Methods: study involved 81 RA treated JAKis from Hospital La Paz Reina Sofía. Patients were classified according BMI as normal weight overweight/obesity. The treatment was assessed Clinical Disease Activity Index (CDAI) Score-28 (DAS28) 6 months after initiation JAKis. Serum adipokines (leptin adiponectin) determined using commercial immunoassay kit samples obtained before Results: Leptin levels showed significant positive correlation at baseline (r = 0.59, p < 0.01) 0.56, whole cohort, but no found between adiponectin. No cohort measured both CDAI DAS28. Fifty (61.7%) achieved low (LDA)/remission months, regardless BMI, differences observed who LDA vs. no-LDA. Conclusions: In this study, we did not find association extent JAKis; therefore, mechanism action could be suitable for overweight/obese

Язык: Английский

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Association of visceral fat metabolism score with risk of rheumatoid arthritis in US adults

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 20, 2025

Background The Visceral Adiposity Index (METS-VF) has emerged as a novel obesity assessment metric. However, research exploring the relationship between METS-VF and rheumatoid arthritis (RA) remains limited. objective of this investigation was to examine correlation prevalence RA METS-VF. Methods NHANES data collected 2011 2018 were used in investigation. To determine association RA, logistic regression analysis used. Sensitivity subgroup done test how reliable results were. Finally, predictive power BMI, waist circumference, for compared using ROC curve analysis. Results This had 8,626 individuals total. findings showed that those without persons with condition noticeably greater levels. significantly positively correlated, according (OR = 1.50, 95% CI 1.12–2.00). sensitivity analyses agreed primary conclusions. indicated possessed superior ability predict BMI circumference. Conclusion study indicates elevated levels are correlated an increased risk US population. Monitoring metric might aid early detection high-risk patients.

Язык: Английский

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Blockade of IL-1 family cytokines in the treatment of rheumatoid arthritis

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 30, 2025

Rheumatoid arthritis (RA), a chronic autoimmune disorder, imposes substantial global health burden through elevated disability rates, systemic complications, and socioeconomic consequences. Chronic synovitis progressive joint destruction characterize this disease, driven by dysregulated innate adaptive immune responses that amplify synovial inflammation, osteoclastogenesis, irreversible tissue damage. Aberrant activation of interleukin (IL) -1 family cytokines critically contributes to RA pathogenesis. These mediate dual mechanisms: pro-inflammatory agonists like IL-1β, IL-18, IL-36 accelerate disease progression, whereas insufficient levels anti-inflammatory antagonists such as IL-1Ra IL-37 disrupt the balance required suppress pathogenic cascades. Clinical trials evaluating IL-1-targeting biologics—including anakinra canakinumab—have demonstrated robust early efficacy. However, late-stage interventions exhibit diminished therapeutic returns, largely due damage compensatory redundant cytokine networks. findings emphasize need for precise patient stratification. Single-pathway IL-1 inhibition faces inherent limitations, driving development multi-target strategies counteract redundancy reduce resistance. This review systematically analyzes mechanistic roles in RA, evaluates clinical outcomes safety profiles IL-1-targeted therapies, proposes innovative advance treatment.

Язык: Английский

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ROS-triggered and macrophage-targeted micelles modulate mitochondria function and polarization in obesity

Nanotechnology, Год журнала: 2024, Номер 35(47), С. 475707 - 475707

Опубликована: Сен. 6, 2024

Abstract Inflammation involving adipose macrophages is an important inducer of obesity. Regulating polarization and improving the inflammatory microenvironment tissue a new strategy for treatment An amphiphilic chondroitin sulfate phenylborate derivative (CS-PBE) was obtained by modifying main chain with hydrophobic small molecule phenylborate. Using CS-PBE self-assembly, macrophage targeting, reactive oxygen species (ROS) release celastrol (CLT) encapsulation were achieved. The cytotoxicity, cellular uptake, internalization pathways transmembrane transport efficiency micelles studied in Caco-2 RAW264.7 cells. Hemolysis organotoxicity tests performed to assess safety platform, while its therapeutic efficacy investigated high-fat diet-induced obese mice. Multifunctional targeting ROS clearance capabilities developed improve CLT treating In vitro studies indicated that had better ability target M1 macrophages, protective effects on mitochondrial function, reduce number LPS-stimulated M2 scavenge macrophages. vivo have shown inflammation significantly toxicity summary, could alleviate inflammation, suggesting are highly promising approach

Язык: Английский

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