TRIM25, TRIM28 and TRIM59 and Their Protein Partners in Cancer Signaling Crosstalk: Potential Novel Therapeutic Targets for Cancer DOI Creative Commons
De Chen Chiang, Beow Keat Yap

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(10), С. 10745 - 10761

Опубликована: Сен. 25, 2024

Aberrant expression of TRIM proteins has been correlated with poor prognosis and metastasis in many cancers, acting as key oncogenic factors. are actively involved cancer signaling pathways, such p53, Akt, NF-κB, MAPK, TGFβ, JAK/STAT, AMPK Wnt/β-catenin. Therefore, this review attempts to summarize how three the most studied TRIMs recent years (i.e., TRIM25, TRIM28 TRIM59) directly indirectly crosstalk between pathways. A brief overview pathways their general cross talking is discussed. In addition, direct interacting protein partners these also highlighted give a picture potential protein–protein interaction that can be targeted for future discovery development novel therapeutics against cancer. This includes some examples which have proposed master switches various

Язык: Английский

TRIM25, TRIM28 and TRIM59 and Their Protein Partners in Cancer Signaling Crosstalk: Potential Novel Therapeutic Targets for Cancer DOI Creative Commons
De Chen Chiang, Beow Keat Yap

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(10), С. 10745 - 10761

Опубликована: Сен. 25, 2024

Aberrant expression of TRIM proteins has been correlated with poor prognosis and metastasis in many cancers, acting as key oncogenic factors. are actively involved cancer signaling pathways, such p53, Akt, NF-κB, MAPK, TGFβ, JAK/STAT, AMPK Wnt/β-catenin. Therefore, this review attempts to summarize how three the most studied TRIMs recent years (i.e., TRIM25, TRIM28 TRIM59) directly indirectly crosstalk between pathways. A brief overview pathways their general cross talking is discussed. In addition, direct interacting protein partners these also highlighted give a picture potential protein–protein interaction that can be targeted for future discovery development novel therapeutics against cancer. This includes some examples which have proposed master switches various

Язык: Английский

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