Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160620 - 160620
Опубликована: Фев. 1, 2025
Язык: Английский
Macrophage Membrane‐Biomimetic Multi‐Layered Nanoparticles Targeting Synovial Angiogenesis for Osteoarthritis Therapy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Osteoarthritis
(OA)
is
an
inflammatory
and
progressive
joint
disease
characterized
by
angiogenesis‐mediated
sustained,
chronic,
low‐grade
synovitis.
Anti‐angiogenesis
emerging
as
a
strategy
for
attenuating
OA
progression,
but
often
compromised
poor
targeted
drug
delivery
immune
clearance.
Recent
studies
have
identified
macrophages
formed
“protective
barrier”
in
the
lining
layer
(LL)
of
synovium,
which
blocked
communication
cavity
sublining
(SL)
synovium.
Inspired
natural
mimicry,
macrophage
membrane‐camouflaged
explored
to
avoid
Based
on
single
cell
RNA
sequencing,
CD34
+
synovial
cells
are
“sentinel
cells”
synovium
angiogenesis.
Consequently,
antibody‐modified
membrane
constructed
target
new
Hence,
biomimetic
multi‐layered
nanoparticle
(NP)
developed
that
incorporates
axitinib‐loaded
poly(lactic‐co‐glycolic)
acid
(PLGA)
with
antibody
modified
(Atb@NP@Raw@CD34)
specifically
deliver
axitinib
(Atb)
SL
sustain
inhibiting
angiogenesis
without
elimination.
It
found
Atb@NP@Raw@CD34
can
pass
through
“barrier”,
targeting
cells,
continuously
releasing
Atb
anti‐angiogenesis
Furthermore,
vivo
data
demonstrated
attenuate
degeneration
In
conclusion,
local
injection
presents
promising
approach
clinically
impeding
progression.
Язык: Английский
Iron chelation therapy and chondrocyte health in osteoarthritis management in patients with beta thalassaemia major
International Immunopharmacology,
Год журнала:
2024,
Номер
144, С. 113601 - 113601
Опубликована: Ноя. 22, 2024
Язык: Английский
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 18, 2024
Osteoarthritis
(OA)
is
one
of
the
leading
causes
disability
worldwide,
characterized
by
a
complex
pathological
process
involving
cartilage
degradation,
synovial
inflammation,
and
subchondral
bone
remodeling.
In
recent
years,
ferroptosis,
form
programmed
cell
death
driven
iron-dependent
lipid
peroxidation,
has
been
recognized
as
playing
critical
role
in
onset
progression
OA.
Investigating
molecular
mechanisms
ferroptosis
its
involvement
OA
may
offer
novel
strategies
for
diagnosing
treating
this
disease.
This
review
first
outlines
core
with
particular
focus
on
roles
molecules
such
Glutathione
Peroxidase
4
(GPX4),
Transferrin
Receptor
1
(TfR1),
Nuclear
Coactivator
(NCOA4).
Subsequently,
study
examines
specific
impacts
pathophysiology
Building
this,
potential
ferroptosis-related
biomarkers
diagnosis
treatment
highlighted,
along
proposed
therapeutic
targeting
regulation.
aims
to
deepen
understanding
advance
clinical
application
regulatory
therapies
Язык: Английский