Re-Evaluating Platelet-Rich Plasma Dosing Strategies in Sports Medicine: The Role of the “10 Billion Platelet Dose” in Optimizing Therapeutic Outcomes—A Narrative Review
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(8), С. 2714 - 2714
Опубликована: Апрель 15, 2025
Platelet-rich
plasma
(PRP)
therapy
is
increasingly
recognized
as
a
promising
treatment
for
musculoskeletal
disorders,
including
osteoarthritis
(OA),
tendinopathy,
and
muscle
injuries.
This
narrative
review
synthesizes
the
current
literature
to
evaluate
efficacy
of
PRP,
with
focus
on
platelet
dosing
strategies,
leukocyte
composition,
preparation
protocols.
Evidence
suggests
that
optimal
therapeutic
outcomes
are
achieved
when
doses
exceed
3.5
billion
per
injection,
cumulative
10–12
across
multiple
treatments.
In
intra-articular
applications,
leukocyte-poor
PRP
(LP-PRP),
characterized
by
reduced
neutrophil
content,
demonstrates
superior
compared
leukocyte-rich
(LR-PRP).
However,
its
effectiveness
in
tendon
regeneration
remains
subject
debate.
Preliminary
data
suggest
inclusion
peripheral
blood
mononuclear
cells
(PBMNCs)
may
enhance
efficacy,
though
robust
clinical
trials
required
confirm
these
findings.
Furthermore,
red
cell
contamination
pre-activation
have
been
identified
detrimental
effectiveness,
highlighting
need
standardized
emphasizes
importance
tailoring
formulations
patient-specific
factors
conditions.
Future
research
should
refining
techniques,
identifying
compositions,
establishing
guidelines
outcomes.
Язык: Английский
Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes
iScience,
Год журнала:
2024,
Номер
28(1), С. 111594 - 111594
Опубликована: Дек. 13, 2024
Язык: Английский
Formation of bovine serum albumin-galangin nanoparticles and their potential to inhibit ROS-induced inflammation: Enthanol desolvation vs. pH-shiftng method
Journal of Dairy Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
pH-shifting
method,
as
an
eco-friendly
approach,
is
a
promising
alternative
to
desolvation
yet
systematic
comparison
of
their
property
still
lacking.
In
this
study,
bovine
serum
albumin-galangin
nanoparticles
(BSA-GA
NPs)
were
designed
for
alleviating
ROS-mediated
macrophage
inflammation
by
the
2
separate
methods.
Compared
with
BSA
exhibited
higher
loading
capacity
GA
under
which
was
attributed
exposure
binding
site
leading
enhanced
affinity
and
more
compact
particle
structure.
Further
analyses
evidenced
that
electron
arrangement
crystal
structure
changed
different
The
content
random
coil
elevated
after
method.
Besides,
smaller
size
rendered
treated
BSA-GA
NPs
easier
be
taken
up
macrophages,
while
specific
surface
area
conferred
excellent
ROS
scavenging
anti-inflammatory
performances.
This
study
may
provide
new
insights
into
choice
Язык: Английский