Mesenchymal stem cells-derived small extracellular vesicles and apoptotic extracellular vesicles for wound healing and skin regeneration: a systematic review and meta-analysis of preclinical studies
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 24, 2025
Studies
examining
the
therapeutic
potential
of
Mesenchymal
stem
cells-derived
extracellular
vesicles
(MSC-EVs)
in
wound
healing
and
skin
regeneration
have
progressed
rapidly.
Prior
to
considering
clinical
translation,
a
systematic
comprehensive
understanding
these
experimental
details
overall
impact
MSC-EVs
on
is
necessary.
83
studies
were
identified
Web
Science,
Embase,
PubMed
that
satisfied
set
prespecified
inclusion
criteria.
A
random
effects
meta-analysis
was
conducted
for
closure
rate,
scar
width,
blood
vessel
density
collagen
deposition.
Our
findings
demonstrate
clear
be
developed
as
therapy
both
diabetic
non-diabetic
animal
models.
Moreover,
subgroup
analyses
demonstrated
apoptotic
small
(ApoSEVs)
showed
better
efficacy
than
bodies
(ApoBDs)
(sEVs)
outcome
deposition,
while
sEVs
displayed
ApoEVs
revascularization.
Among
frequently
used
routes
administration,
subcutaneous
injection
greater
improvement
closure,
deposition
revascularization
compared
dressing/covering.
easier-access
source
MSCs,
ADSCs
best
effect
rate
compared,
BMMSCs
Additionally,
high
heterogeneity
observed
collection
conditions,
separation
methods,
storage
modifications,
treatment
dose,
administration
route,
frequency
underscores
urgent
need
standardization
areas,
prior
translation.
PROSPERO
CRD42024499172.
Язык: Английский
New perspectives on the treatment of diabetic nephropathy: Challenges and prospects of mesenchymal stem cell therapy
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177543 - 177543
Опубликована: Март 1, 2025
Язык: Английский
Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine
Diagnostics,
Год журнала:
2025,
Номер
15(8), С. 973 - 973
Опубликована: Апрель 11, 2025
Diabetes
mellitus
(DM)
has
emerged
as
the
most
common
cause
of
chronic
kidney
disease
(CKD)
and
end-stage
renal
(ESRD)
globally
in
recent
years.
Diabetic
nephropathy
(DN),
or
diabetic
(DKD)
that
occurs
a
direct
consequence
DM,
complex
pathophysiological
mechanisms,
such
various
inflammatory
processes
genetic
epigenetic
factors,
often
accentuated
by
comorbid
illnesses
like
hypertension
dyslipidemia.
Therefore,
management
DKD
involves
targeting
these
etio-pathological
processes.
Various
medications
with
remarkable
modifying
properties
have
been
introduced
for
treatment
DN
We
update
current
future
diagnostic
therapeutic
landscapes
against
this
article.
Язык: Английский
Renal fibrosis progression following partial unilateral ureteral obstruction: mechanisms and therapeutic insights
World Journal of Urology,
Год журнала:
2025,
Номер
43(1)
Опубликована: Апрель 17, 2025
Язык: Английский
Mesenchymal Stem Cell Therapy: Therapeutic Opportunities and Challenges for Diabetic Kidney Disease
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10540 - 10540
Опубликована: Сен. 30, 2024
Diabetic
kidney
disease
(DKD)
is
the
leading
cause
of
end-stage
renal
(ESRD),
which
severely
affects
quality
patients’
lives.
However,
current
therapeutic
approaches
can
only
postpone
its
progression
to
ESRD.
It
therefore
imperative
develop
a
novel
strategy
for
injury
in
DKD,
with
objective
restoring
function
and
reversing
process
In
recent
years,
potential
mesenchymal
stem
cell
(MSC)
therapy
DKD
has
garnered
increasing
attention
within
scientific
community.
Preclinical
research
on
MSC
yielded
promising
results,
safety
treatment
vivo
been
substantiated
clinical
studies.
An
body
evidence
suggests
that
significant
DKD.
This
article
reviews
existing
MSCs
their
derived
exosomes
treating
analyzes
underlying
mechanism
MSC-based
Additionally,
we
discuss
combining
conventional
pharmacological
treatments,
along
constraints
prospects
We
hope
this
review
provide
precise
comprehensive
understanding
Язык: Английский
Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases
Life,
Год журнала:
2024,
Номер
14(12), С. 1671 - 1671
Опубликована: Дек. 17, 2024
The
kidneys
contribute
to
the
overall
health
of
an
organism
by
maintaining
systemic
homeostasis.
This
process
involves
various
biological
mechanisms,
in
which
Krüppel-like
factors
(KLFs),
a
family
transcription
factors,
are
essential
for
regulating
development,
differentiation,
proliferation,
and
cellular
apoptosis.
They
also
play
role
metabolic
regulation
nutrients,
such
as
glucose
lipids.
dysregulation
these
is
associated
with
development
pathologies,
can
ultimately
lead
renal
fibrosis,
severely
compromising
kidney
function.
In
this
context,
present
article
provides
comprehensive
review
existing
literature,
offering
enriching
analysis
findings
related
KLFs
nephrology,
while
highlighting
their
potential
therapeutic
treatment
diseases.
Язык: Английский