Lead as an environmental toxicant in models of synucleinopathies

Chemosphere, Год журнала: 2025, Номер 380, С. 144477 - 144477

Опубликована: Май 9, 2025

Язык: Английский

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Roles of gut microbiome-associated metabolites in pulmonary fibrosis by integrated analysis

npj Biofilms and Microbiomes, Год журнала: 2024, Номер 10(1)

Опубликована: Дек. 19, 2024

Язык: Английский

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Lead as a toxic environmental toxicant in models of synucleinopathies

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Lead, a toxic heavy metal, is prevalent in various industrial applications, contributing to environmental contamination and significant health concerns. Lead affects body systems, especially the brain, causing long-lasting cognitive behavioral changes. While most studies have focused on continuous lead exposure, intermittent such as that caused by migration or relocations, has received less attention. Importantly, exposure intensifies severity of Parkinson’s disease (PD) dementia with Lewy bodies, diseases involving accumulation alpha-synuclein (aSyn) brain gut. Although, precise mechanisms underlying these observations remain unclear, oxidative stress mitochondrial dysfunction likely play role. Here, we investigated how two different profiles - affect models synucleinopathies. We found enhances formation aSyn inclusions, resulting an increase both their number size cell models. In addition, animals injected pre-formed fibrils display serine 129-phosphorylated inclusions reduction astrocytes substantia nigra. These also neuronal damage alterations locomotor activity, exploratory behavior, anxiety, memory impairments hypertension. Our results suggest mechanistic link between onset progression associated pathology. Understanding molecular cellular interactions crucial for shaping public policies may provide novel insight into strategies mitigating impact toxins neurodegenerative processes involved related Key points summary increases models.∼ Animals exposed show increased phosphorylation aSyn, reduced astrogliosis nigra . Lead-exposed exhibit impaired locomotion, deficits, hypertension chemoreceptor reflex hypersensitivity. The study suggests pathology, disease.

Язык: Английский

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Lead as an Environmental Toxicant in Models of Synucleinopathies

Опубликована: Янв. 1, 2024

Язык: Английский

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