The role of cGAS-STING signaling pathway in ferroptosis DOI Creative Commons
Lina Ding, R Zhang,

Wenqi Du

и другие.

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence lipid peroxidation, represents specialized form cell death. A burgeoning collection studies demonstrated that the cGAS-STING participates homeostatic regulation organism modulating ferroptosis-associated enzyme activity or gene expression. Consequently, elucidating specific roles STING ferroptosis vivo is vital for targeted disease intervention. This review systematically examines interactions between ferroptosis, highlighting their influence on progression contexts inflammation, injury, cancerous dynamics. Understanding these may provide novel therapeutic strategies. implicated various death mechanisms, including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis. Our focus primarily addresses role diseases, limiting discussion other modalities precluding comprehensive overview pathway's additional functions.

Язык: Английский

Convergent inducers and effectors of T cell paralysis in the tumour microenvironment DOI
Douglas Hanahan, Olivier Michielin, Mikaël J. Pittet

и другие.

Nature reviews. Cancer, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Язык: Английский

Процитировано

9
A central role of stimulator of interferon genes’ adaptor protein in defensive immune response DOI
Anju Kaushal

Immunologic Research, Год журнала: 2025, Номер 73(1)

Опубликована: Янв. 21, 2025

Язык: Английский

Процитировано

0
Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models DOI Creative Commons

Linglin Tian,

Huiyang Gao,

Yao Tian

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Ulcerative colitis (UC) is a chronic inflammatory disease of the colonic mucosa with increasing incidence worldwide. Growing evidence highlights pivotal role nicotinamide adenine dinucleotide (NAD+) metabolism in UC pathogenesis, prompting our investigation into subtype-specific molecular underpinnings and diagnostic potential NAD+ metabolism-related genes (NMRGs). Transcriptome data from patients healthy controls were downloaded GEO database, specifically GSE75214 GSE87466. We performed unsupervised clustering based on differentially expressed (DE-NMRGs) to classify cases distinct subtypes. GSEA GSVA identified biological pathways active within these subtypes, while CIBERSORT algorithm assessed differential immune cell infiltration. Weighted gene co-expression network analysis (WGCNA) combined expression was used pinpoint specific NMRGs UC. Robust features for subtyping diagnosis selected using two machine learning algorithms. Nomograms constructed their effectiveness evaluated receiver operating characteristic (ROC) curves. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) conducted verify lines. In study, classified subtypes DE-NMRGs levels, Cluster A exhibiting enhanced self-repair capabilities during responses B showing greater inflammation tissue damage. Through comprehensive bioinformatics analyses, we four key biomarkers (AOX1, NAMPT, NNMT, PTGS2) subtyping, (NNMT, PARP9) its diagnosis. These are closely linked various cells microenvironment, particularly NAMPT PTGS2, which strongly associated neutrophil developed demonstrated high predictive accuracy, achieving area under curve (AUC) values up 0.989 0.997 training set 0.998 0.988 validation sets. RT-qPCR showed significant upregulation NNMT PARP9 inflamed versus normal epithelia, underscoring relevance. Our study reveals UC, identifying findings could suggest therapeutic targets contribute advancing personalized treatment strategies potentially improving patient outcomes.

Язык: Английский

Процитировано

0
Targeting DNA Damage Repair to Enhance Antitumor Immunity in Radiotherapy: Mechanisms and Opportunities DOI Open Access
Lin Yang,

Wenjie Wei,

Xun Yuan

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3743 - 3743

Опубликована: Апрель 16, 2025

Radiotherapy is a standard cancer treatment that involves the induction of DNA damage. damage repair (DDR) pathways maintain genomic integrity and make tumors resistant to radiotherapy certain chemotherapies. In turn, DDR dysfunction results in cumulative damage, leading increased sensitivity for antitumor treatment. Moreover, has been shown trigger immunity. Currently, immunotherapy become new widely used strategy treating broad spectrum tumor types. Notably, recent studies have demonstrated play important roles driving response immunotherapy. Herein, we review discuss how affects immunity induced by radiotherapy. Furthermore, summarize development strategies combining inhibitors with and/or enhance their efficacy against cancers.

Язык: Английский

Процитировано

0
The roles of DNA damage repair and innate immune surveillance pathways in HPV pathogenesis DOI
Takeyuki Kono,

Hiroyuki Ozawa,

Laimonis A. Laimins

и другие.

Virology, Год журнала: 2024, Номер 600, С. 110266 - 110266

Опубликована: Окт. 18, 2024

Язык: Английский

Процитировано

1
Transcriptomic landscapes of STING-mediated DNA-sensing reveal cellular response heterogeneity DOI Creative Commons

Ling-Zu Kong,

In-Hwan Jang,

Chunli Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138752 - 138752

Опубликована: Дек. 1, 2024

Transfection of plasmid DNA (pDNA) encoding target genes is a routine tool in gene function studies and therapeutic applications. However, nucleic acid-sensing-mediated innate immune responses influence multiple intracellular signaling pathways. The stimulator interferon (STING) crucial adapter protein for sensors mammalian cells. In this study, we explored the molecular mechanisms underlying sensing by investigating relationship between mRNA expression levels STING pathway using single-cell analysis. We observed that reporter was dose-nonlinear after transfection pDNA cells with intact DNA-sensing Moreover, blocking THP-1 significantly downregulated responses, upregulated exogenous expression, mitigated effects on cell function, but did not affect proportion protein-positive elucidated sensing-induced response death analyzing heterozygous cellular to transcriptome changes positive These findings suggest regulation STING-mediated acid-sensing pathways accuracy could enhance efficacy therapy.

Язык: Английский

Процитировано

0
The role of cGAS-STING signaling pathway in ferroptosis DOI Creative Commons
Lina Ding, R Zhang,

Wenqi Du

и другие.

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence lipid peroxidation, represents specialized form cell death. A burgeoning collection studies demonstrated that the cGAS-STING participates homeostatic regulation organism modulating ferroptosis-associated enzyme activity or gene expression. Consequently, elucidating specific roles STING ferroptosis vivo is vital for targeted disease intervention. This review systematically examines interactions between ferroptosis, highlighting their influence on progression contexts inflammation, injury, cancerous dynamics. Understanding these may provide novel therapeutic strategies. implicated various death mechanisms, including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis. Our focus primarily addresses role diseases, limiting discussion other modalities precluding comprehensive overview pathway's additional functions.

Язык: Английский

Процитировано

0