Small HSPs at the crossroad between protein aggregation, autophagy and unconventional secretion: clinical implications and potential therapeutic opportunities in the context of neurodegenerative diseases DOI Creative Commons
Raffaella Bonavita,

Fulvia Vitale,

Luigi Vittorio Verdicchio

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Май 2, 2025

Neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s and Huntington’s well ataxias fronto-temporal disorders are all characterized by the progressive accumulation of protein aggregates (amyloids) into inclusions bodies. In addition, recent experimental evidence is challenging conventional view disease revealing ability some these disease-relevant proteins to be transferred between cells means extracellular vesicles (EVs), allowing mutant seed oligomers involving both wild type forms protein. Abnormal secretion levels EVs closely related pathogenesis neurodegenerative contribute progression. Numerous studies have proposed therapeutic targets or biomarkers for diseases. this review, we summarize discuss role small heat shock (sHSPs) autophagy in cellular quality control turn-over major aggregation-prone associated disorders. We also highlight advanced research progress on mechanisms regulating unconventional secretion, secretory biogenesis their contribution pathological processes underlining Finally, outline latest roles potential diagnostic significance treatment clinically relevant conditions.

Язык: Английский

INTERACTION OF SMALL HEAT SHOCK PROTEINS WITH BAG3 DOI
Maria A Zamotina, Lydia K. Muranova,

Arthur I Zabolotskii

и другие.

Biochimie, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Small HSPs at the crossroad between protein aggregation, autophagy and unconventional secretion: clinical implications and potential therapeutic opportunities in the context of neurodegenerative diseases DOI Creative Commons
Raffaella Bonavita,

Fulvia Vitale,

Luigi Vittorio Verdicchio

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Май 2, 2025

Neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s and Huntington’s well ataxias fronto-temporal disorders are all characterized by the progressive accumulation of protein aggregates (amyloids) into inclusions bodies. In addition, recent experimental evidence is challenging conventional view disease revealing ability some these disease-relevant proteins to be transferred between cells means extracellular vesicles (EVs), allowing mutant seed oligomers involving both wild type forms protein. Abnormal secretion levels EVs closely related pathogenesis neurodegenerative contribute progression. Numerous studies have proposed therapeutic targets or biomarkers for diseases. this review, we summarize discuss role small heat shock (sHSPs) autophagy in cellular quality control turn-over major aggregation-prone associated disorders. We also highlight advanced research progress on mechanisms regulating unconventional secretion, secretory biogenesis their contribution pathological processes underlining Finally, outline latest roles potential diagnostic significance treatment clinically relevant conditions.

Язык: Английский

Процитировано

0