From Gut to Brain: The Impact of Short-Chain Fatty Acids on Brain Cancer
NeuroMolecular Medicine,
Год журнала:
2025,
Номер
27(1)
Опубликована: Янв. 16, 2025
Язык: Английский
Gut microbiome is associated with radiotherapy response in lung cancer patients with brain metastases
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Март 10, 2025
Purpose
To
investigate
the
gut
microbiome
of
lung
cancer
patients
with
brain
metastases
undergoing
radiotherapy,
identify
key
microorganisms
associated
radiotherapy
response,
and
evaluate
their
potential
as
biomarkers.
Methods
materials
This
study
enrolled
55
newly
diagnosed
metastases.
Fecal
samples
were
collected
before
analyzed
by
16S
rRNA
sequencing
to
assess
microbiome’s
composition
function.
Patients
categorized
into
response
(n=28)
non-response
(n=27)
groups
based
on
treatment
efficacy,
α-diversity,
β-diversity,
functional
pathways
compared
between
them.
Linear
Discriminant
Analysis
Effect
Size
was
used
microbial
features
efficacy.
Logistic
regression
analyses
performed
predictive
capacity
clinical
factors
for
outcomes.
Results
No
significant
difference
in
α-diversity
observed
(P
>
0.05),
but
β-diversity
differed
significantly
=
0.036).
Twelve
characteristic
identified
group,
including
g_
Oscillibacter
Blautia
,
nine
such
f_
Desulfovibrionaceae
Megamonas
.
Metabolic
included
ketone
body
metabolism
related
amyotrophic
lateral
sclerosis.
Multivariate
analysis
g_Flavonifractor
(odds
ratio
[OR]
6.680,
P
0.004),
g_Negativibacillus
(OR
3.862,
0.014),
C-reactive
protein
1.054,
0.017),
systemic
inflammation
index
1.367,
0.043)
independent
predictors
response.
The
nomogram
models
achieved
area
under
curve
(AUC)
values
0.935
0.866,
respectively,
demonstrating
excellent
performance.
Decision
further
confirmed
these
provided
net
benefits
across
risk
thresholds.
Conclusions
characteristics
prior
are
therapeutic
possess
Further
studies
warranted
validate
findings.
Язык: Английский
Targeting gut microbiota: a potential therapeutic approach for tumor microenvironment in glioma
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Март 21, 2025
Glioma,
being
one
of
the
malignant
tumors
with
highest
mortality
rate
globally,
has
an
unclear
pathogenesis,
and
existing
treatment
effects
still
have
certain
limitations.
The
tumor
microenvironment
(TME)
plays
important
role
in
occurrence,
development,
recurrence
glioma.
As
regulatory
factors
TME,
gut
microbiota
can
regulate
progression
glioma
not
only
by
interacting
brain
through
brain-gut
axis
but
also
influencing
immune
(TIME)
inflammatory
microenvironment.
Recent
studies
identified
TME
as
potential
therapeutic
targets
for
This
paper
aims
to
summarize
association
between
them
glioma,
developing
new
intervention
measures
targeting
microbiota.
Understanding
involvement
process
may
pave
way
development
effective
methods
that
prevent
disease
progression.
Язык: Английский
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota
Experimental and Molecular Pathology,
Год журнала:
2025,
Номер
142, С. 104964 - 104964
Опубликована: Апрель 8, 2025
The
gut-lung
axis,
a
vital
signaling
network
linking
the
gastrointestinal
and
pulmonary
systems,
regulates
immune
responses
progression
of
respiratory
diseases.
Nutritional
components
can
modulate
gut
microbiome
regulate
synthesis
critical
intestinal
microbial
metabolites,
which
are
essential
for
maintaining
homeostasis
supporting
health.
Conversely,
poor
dietary
habits
exacerbate
asthma
other
conditions
through
modulation
systemic
inflammation
responses.
Dietary
interventions,
such
as
Mediterranean
diet,
reported
to
restore
balance
improve
health
by
increasing
production
anti-inflammatory
potentiating
responses,
preserving
epithelial
barrier
integrity.
In
contrast,
Western
patterns,
characterized
high
fat
low
fiber
intake,
disrupt
diversity,
resulting
in
increased
levels
pro-inflammatory
metabolites
that
aggravate
airway
severity.
This
review
aimed
elucidate
mechanisms
underlying
regulatory
effects
microbes
their
on
asthma.
Additionally,
previous
findings
related
axis
have
been
summarized,
providing
insights
into
potential
therapeutic
strategies
management.
Язык: Английский
Comprehensive bioinformatics and immunohistochemical analyses identify phosphoinositide metabolism and PNPLA7 as potential biomarkers in urological cancers
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 12, 2025
Phosphoinositides
(PI)
and
their
metabolic
enzymes
are
known
to
be
involved
in
cellular
processes
associated
with
the
hallmarks
of
cancer.
The
impact
PI
metabolism-related
components
on
urinary
tract
(or
urological)
cancers,
however,
remains
unexplored.
Considering
this,
herein,
we
performed
a
comprehensive
bioinformatic
analysis
clear
cell
renal
carcinoma,
bladder
cancer,
adenocarcinoma
prostate
using
public
databases
investigate
relative
contribution
metabolism
these
clinical
phenotypes.
Primarily,
computed
phosphoinositide
scores
assess
biological
further
enriched
by
predicting
drug
sensitivity,
immune
profiling,
risk
stratification.
Besides,
utilized
single-cell
RNA
sequencing
datasets
identify
intercellular
communication
networks
cancer
subtypes.
Of
interest,
our
identified
PNPLA7
gene
as
potential
biomarker
urological
which
validated
immunohistochemical
evaluation
samples.
In
conclusion,
study
reveals
that
is
critical
prognostic
for
cancers
may
guide
therapies,
including
immunosuppressants.
Therefore,
could
serve
target
requires
attention.
Язык: Английский
Modulation of the Immune Environment in Glioblastoma by the Gut Microbiota
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2429 - 2429
Опубликована: Окт. 23, 2024
Studies
increasingly
support
the
role
of
gut
microbiota
in
glioma
development
and
treatment,
although
exact
mechanisms
remain
unclear.
Research
indicates
that
can
influence
progression,
response
to
therapies,
effectiveness
treatments
like
immunotherapy,
with
certain
microbial
compositions
being
linked
better
outcomes.
Additionally,
impacts
tumor
microenvironment,
affecting
both
growth
treatment.
This
review
will
explore
glioma,
microbiota,
how
their
interaction
shapes
therapy
responses.
this
examines
metabolites,
such
as
short-chain
fatty
acids
(SCFAs)
tryptophan,
on
It
also
explores
microbiome
signaling
via
pattern
recognition
receptors,
molecular
mimicry
between
antigens
glioblastoma,
if
these
interactions
affect
Язык: Английский
Combination of lipopolysaccharide and polygalacturonic acid exerts antitumor activity and augments anti-PD-L1 immunotherapy
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
281, С. 136390 - 136390
Опубликована: Окт. 9, 2024
Язык: Английский
The Enigmatic Gut-Brain-Immune Trio in Brain and Behavior Disorders
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 421 - 452
Опубликована: Дек. 13, 2024
The
human
gut
is
a
bustling
colony
of
micro-inhabitants
such
as
bacteria,
archaea,
and
eukarya.
These
microbes
inhabited
the
earth
trillions
years
before
humans,
evolved
along
with
have
now
outnumbered
humans.
It
has
been
established
without
doubt
that
these
microbiota
within
us
play
significant
role
in
maintenance
our
physical
health.
They
exist
symbiotic
and/or
commensal
relationship
host
body
assist
digestion,
metabolism,
regulation
immune
functions.
Interestingly,
recent
reports
suggest
aliens
can
regulated
brain
behaviour
too.
gut-brain
axis
overall
well-being
becoming
increasingly
evident
nurturing
this
connection
might
address
many
challenges
targeting
illnesses
brain.
Moreover,
wake
COVID-19
pandemic,
more
evidences
unfolded
suggesting
impact
peripheral
inflammation
on
mental
Here,
importance
microbes,
system,
their
influence
diseases
addressed.
Язык: Английский