Cardamom extract alleviates tamoxifen-induced liver damage by suppressing inflammation and pyroptosis pathway
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 8, 2025
Tamoxifen
(TAM)
is
extensively
used
to
manage
estrogen
receptor-positive
breast
cancer.
Despite
its
effectiveness,
administration
can
negatively
impact
various
organs,
including
the
liver.
This
research
focused
on
effects
of
TAM
pyroptotic
pathway
in
liver
and
evaluated
potential
cardamom
extract
(CRDE)
lessen
hepatic
damage
female
rats.
Rats
received
45
mg/kg
injections
for
10
days,
while
groups
treated
with
CRDE
12
ml/kg
20
commencing
days
before
administration.
exposure
resulted
apparent
degenerations
tissue
inflammatory
cell
infiltration
loss
architectures.
Serum
levels
enzymes
alanine
aminotransferase,
aspartate
aminotransferase
alkaline
phosphatase
were
elevated,
along
oxidative
stress,
as
shown
by
increased
lipid
peroxidation
lower
reduced
glutathione.
caused
inflammation
indicated
higher
tumor
necrosis
factor-α
interleukin-6
well
expression
CD68;
a
phagocytic
Kupffer's
cells
marker.
Additionally,
protein
analysis
revealed
high
markers
NLRP3-inflammasome,
caspase-1,
gasdermin
D.
Conversely,
treatment
effectively
neutralized
biochemical,
histological,
alterations
induced
TAM.
In
conclusion,
demonstrated
protect
from
TAM-induced
regulating
mechanisms
involving
damage,
inflammation,
pyroptosis.
Язык: Английский
N-acetylserotonin derivative ameliorates hypoxic-ischemic brain damage by promoting PINK1/Parkin-dependent mitophagy to inhibit NLRP3 inflammasome-induced pyroptosis
International Immunopharmacology,
Год журнала:
2025,
Номер
153, С. 114469 - 114469
Опубликована: Март 18, 2025
Язык: Английский
Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca2+]i Stability between Endoplasmic Reticulum and Mitochondria
Biomolecules,
Год журнала:
2024,
Номер
14(9), С. 1135 - 1135
Опубликована: Сен. 8, 2024
Fine
particulate
matter
(PM2.5)
is
a
significant
cause
of
respiratory
diseases
and
associated
cellular
damage.
The
mechanisms
behind
this
damage
have
not
been
fully
explained.
This
study
investigated
two
types
(inflammation
pyroptosis)
induced
by
PM2.5,
focusing
on
their
relationship
with
organelles
(the
endoplasmic
reticulum
mitochondria).
Animal
models
demonstrated
that
PM2.5
induces
excessive
stress
(ER
stress),
which
lung
in
rats.
was
confirmed
pretreatment
an
ER
inhibitor
(4-Phenylbutyric
acid,
4-PBA).
We
found
that,
vitro,
the
intracellular
Ca2+
([Ca2+]i)
dysregulation
rat
alveolar
macrophages
stress.
Changes
mitochondria-associated
membranes
(MAMs)
result
abnormal
mitochondrial
function.
further
massive
expression
NLRP3
GSDMD-N,
detrimental
to
cell
survival.
In
conclusion,
our
findings
provide
valuable
insights
into
between
[Ca2+]i
dysregulation,
damage,
inflammation
pyroptosis
under
PM2.5-induced
conditions.
Their
interactions
ultimately
impact
health.
Язык: Английский